期刊
TRENDS IN MOLECULAR MEDICINE
卷 29, 期 10, 页码 777-779出版社
CELL PRESS
DOI: 10.1016/j.molmed.2023.06.008
关键词
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GLP-1 receptor agonists are highly effective in the treatment of obesity, but their mechanisms of action and whether they can be the long-sought-after solution to obesity are still being studied and discussed.
Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists are hugely effective in the treatment of obesity. Originally developed for type 2 diabetes (T2D), these drugs cause dramatic weight loss in people with overweight or obesity, but how do they work, and are these therapeutics the long-sought-after solution to obesity? Here we explain the mechanisms of action of GLP-1R agonists in the context of weight loss and discuss their importance as therapeutics for obesity treatment.
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