Dietary interventions and precision nutrition in cancer therapy

Article Gastroenterology & Hepatology

Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts

Ting Li et al.

Summary: Methionine and YTHDF1 play a critical role in anticancer immunity through regulating the functions of T cells. Targeting methionine metabolism or YTHDF1 could be a potential new strategy for cancer immunotherapy.

GUT (2023)

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Article Multidisciplinary Sciences

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Joseph Tintelnot et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with limited response to chemotherapy. Researchers have found that the microbiota-derived metabolite, indole-3-acetic acid (3-IAA), is enriched in patients who respond to treatment. Using a combination of 3-IAA and chemotherapy can improve the efficacy of treatment, providing motivation for considering nutritional interventions in cancer patients.

NATURE (2023)

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Article Endocrinology & Metabolism

The antitumour effects of caloric restriction are mediated by the gut microbiome

Yu-Qin Mao et al.

Summary: The study reveals that caloric restriction increases the presence of Bifidobacterium bifidum in the intestine, which ultimately inhibits tumor development in mice. Caloric restriction and intermittent fasting, without causing malnutrition, have been found to reduce the risk of cancer. Additionally, both caloric restriction and intermittent fasting can alter the composition of the gut microbiota. It is shown in this study that caloric restriction, but not intermittent fasting, protects against subcutaneous MC38 tumor formation in female mice through a mechanism involving the gut microbiota. These findings highlight the oncological significance of modulating the gut taxonomic composition in tumor growth and cancer immunosurveillance.

NATURE METABOLISM (2023)

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Review Immunology

Control of immunity via nutritional interventions

Nicholas Collins et al.

Summary: Nutrition plays a profound role in shaping the immune system, with mild reductions in dietary intake enhancing protective immunity and limiting aberrant inflammatory responses. In severe nutritional stress, specific immunological functions are heightened to prioritize survival.

IMMUNITY (2022)

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Article Gastroenterology & Hepatology

Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis

Amanda Garrido et al.

Summary: This study reveals the critical role of MCRS1 in the pathogenesis of cirrhosis, shedding light on potential new treatment strategies for the disease.

JOURNAL OF HEPATOLOGY (2022)

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Article Oncology

Fasting- Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri et al.

Summary: Cyclic fasting or fasting-mimicking diets (FMD) enhance antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. In a clinical trial, the five-day FMD was found to be safe and resulted in consistent decrease of blood glucose and growth factor concentration, recapitulating metabolic changes observed in preclinical experiments. The FMD also reshapes anticancer immunity and improves clinical outcomes in patients with cancer.

CANCER DISCOVERY (2022)

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Article Nutrition & Dietetics

Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial

Martin Voss et al.

Summary: The prospective ERGO2 trial investigated the effects of calorie-restricted ketogenic diet and intermittent fasting on re-irradiation for recurrent brain tumors, showing that the ketogenic diet did not improve progression-free survival. Unexpectedly, the control group had lower calorie intake than expected, while the ketogenic diet group met the preset goals for calorie and carbohydrate restriction.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Oncology

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Ruozheng Wei et al.

Summary: This study identifies ketogenesis as a critical regulator of the tumor microenvironment in colorectal cancer and suggests the potential for ketogenic diets as a metabolic strategy to overcome immunosuppression and prolong survival.

CANCER RESEARCH (2022)

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Article Multidisciplinary Sciences

β-Hydroxybutyrate suppresses colorectal cancer

Oxana Dmitrieva-Posocco et al.

Summary: The study identifies a metabolite signalling pathway that can be used as a strategy for preventing and treating colorectal cancer. Ketogenic diets and the ketone body BHB show a strong inhibitory effect on tumor growth by reducing cell proliferation. The findings suggest that BHB-triggered pathway could play a crucial role in regulating intestinal tumorigenesis.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

John A. McCulloch et al.

Summary: An integrated analysis of microbiome and host cell transcriptional data in patients with melanoma treated with anti-PD-1 therapy reveals new associations between streptococcus species and immune-related adverse effects. The study also identifies consistent microbiome associations with clinical outcomes. The results show that baseline microbiota composition is optimally associated with clinical outcome one year after treatment initiation. Meta-analysis and bioinformatic analyses reveal that bacteria associated with favorable response are within the Actinobacteria phylum and Lachnospiraceae/Ruminococcaceae families of Firmicutes. Gram-negative bacteria, on the other hand, are associated with an inflammatory host intestinal gene signature and unfavorable outcome. Two different microbial signatures, enriched for Lachnospiraceae spp. and Streptococcaceae spp., are associated with favorable and unfavorable clinical response, respectively, along with distinct immune-related adverse effects. Supervised learning algorithms consistently predict treatment outcomes in all cohorts, despite heterogeneity between cohorts. The study provides valuable insights into the complex interaction between gut microbiome and response to cancer immunotherapy, paving the way for future research.

NATURE MEDICINE (2022)

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Article Multidisciplinary Sciences

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Fotios Karagiannis et al.

Summary: This study found that impaired production of beta-hydroxybutyrate (BHB) is associated with severe COVID-19 respiratory distress syndrome. BHB promotes the survival and interferon-gamma production of CD4(+) T cells. BHB acts as an alternative carbon source, fueling oxidative phosphorylation and maintaining the redox balance.

NATURE (2022)

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Article Nutrition & Dietetics

Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial

Rafael Ferraz-Bannitz et al.

Summary: This study aimed to investigate the benefits of dietary restriction in patients with metabolic syndrome and determine whether it is the calorie or protein restriction that mediates the effects. The findings showed that isocaloric dietary protein restriction can achieve similar clinical outcomes as calorie restriction, making it a more attractive and less drastic dietary strategy for patients with metabolic syndrome and has potential as an adjuvant therapy.

NUTRIENTS (2022)

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Article Oncology

Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub- analysis of the NCT03340935 trial

Francesca Ligorio et al.

Summary: This study reports on several cases of advanced cancer patients achieving complete and long-lasting tumor remission through a combination of cyclic fasting-mimicking diets and standard anticancer therapies in the context of a clinical trial.

EUROPEAN JOURNAL OF CANCER (2022)

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Review Oncology

Developing dietary interventions as therapy for cancer

Samuel R. Taylor et al.

Summary: This Review discusses metabolic alterations and vulnerabilities in different types of cancer, and suggests using dietary interventions in combination with pharmacologic therapies to target these changes. However, diet studies in cancer patients are rare and lack robust evidence. The article also explores how dietary strategies can be combined with pharmacological therapies in treating cancer.

NATURE REVIEWS CANCER (2022)

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Article Oncology

Diet and cancer risk reduction: The role of diet-microbiota interactions and microbial metabolites

Tiffany L. Weir et al.

Summary: Cancer is a common disease, with complex interactions between diet, gut microbiota, and cancer risk. Lifestyle modifications, especially in diet, can prevent as much as 50% of cancer cases. Understanding the interplay between diet and gut microbiota helps clarify the impact of diet on cancer.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Microbiology

Gut microbiota in human metabolic health and disease

Yong Fan et al.

Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Cell Biology

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

Giulia Salvadori et al.

Summary: The study demonstrates that a fasting-mimicking diet activates starvation escape pathways in TNBC cells and reduces stemness markers in CSCs, leading to decreased cell numbers and improved mouse survival. Additionally, the diet activates different survival/growth pathways in differentiated cancer cells, which can be targeted by drugs to promote tumor regression.

CELL METABOLISM (2021)

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Article Nutrition & Dietetics

Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial

Juan C. Laguna et al.

Summary: This study found an association between intake of simple sugars in drinks and fruit juice and increased risk of overall cancer incidence and mortality, suggesting that sugary beverages may be a modifiable risk factor for cancer and all-cause mortality.

CLINICAL NUTRITION (2021)

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Article Biochemistry & Molecular Biology

Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake

Kevin D. Hall et al.

Summary: In an inpatient, randomized controlled crossover trial, participants consumed 550-700 fewer calories per day when following a plant-based, low-fat diet with a high glycemic load compared with an animal-based, low-carbohydrate diet with a low glycemic load; weight loss was comparable between the two diets and there were no significant differences in hunger or enjoyment of the meals.

NATURE MEDICINE (2021)

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Article Surgery

Effect of Fasting-Mimicking Diet or Continuous Energy Restriction on Weight Loss, Body Composition, and Appetite-Regulating Hormones Among Metabolically Healthy Women with Obesity: a Randomized Controlled, Parallel Trial

Mehdi Sadeghian et al.

Summary: This study found that there was no significant difference in weight loss between FMD and CER. However, FMD was more effective at reducing insulin resistance, regulating appetite-regulating hormones, and preserving muscle mass and BMR.

OBESITY SURGERY (2021)

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Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

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Article Multidisciplinary Sciences

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Gloria Pascual et al.

Summary: The study suggests that dietary palmitic acid (PA), but not oleic acid or linoleic acid, may promote metastasis in oral carcinomas and melanoma in mice. The PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with stable deposition of histone H3 lysine 4 trimethylation by methyltransferase Set1A. Furthermore, the proregenerative state of tumor-activated Schwann cells induced by PA may play a role in long-term stimulation of metastasis.

NATURE (2021)

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Article Multidisciplinary Sciences

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Christine N. Spencer et al.

Summary: The study suggests that dietary fiber intake is associated with significantly improved progression-free survival in melanoma patients receiving ICB treatment, especially without the use of probiotics. Preclinical studies demonstrate that a low-fiber diet or probiotics can impair the treatment response to anti-PD-1 therapy, leading to a lower frequency of interferon-gamma-positive cytotoxic T cells in the tumor microenvironment.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

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Review Nutrition & Dietetics

Vegan Diet Health Benefits in Metabolic Syndrome

Giulia Marrone et al.

Summary: A plant-based diet, particularly veganism, is becoming more popular for ethical, health, and environmental reasons. While a well-balanced vegan diet can promote optimal health, deficiencies in certain nutrients may occur if not properly managed. In addition, compared to omnivorous diets, vegan diets may reduce the risk of chronic diseases and have a lower environmental impact.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition

Laura C. D. Pomatto-Watson et al.

Summary: Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. Alternative dietary interventions for cancer protection, such as plant-based diet mimicking fasting (FMD), are being explored, with results showing that daily CR provides greater protection against tumor growth and metastasis compared to periodic caloric cycling in a murine model of breast cancer.

NATURE COMMUNICATIONS (2021)

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Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Review Oncology

Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy

Chiara Vidoni et al.

Summary: Cancer remains a significant health problem worldwide despite efforts to find new and more effective treatments. Calorie restriction, as well as caloric restriction mimetics, are being explored as potential interventions for preventing or slowing down cancer progression. Research shows that reducing calorie intake through dietary adjustments can impact tumor microenvironment and cancer metabolism, leading to reduced growth and progression of cancer.

JOURNAL OF CANCER PREVENTION (2021)

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Review Oncology

Selenium stimulates the antitumour immunity: Insights to future research

Ali Razaghi et al.

Summary: Selenium is a crucial trace element for regulating immune functions and plays important roles in cancer. At nutritional low doses, selenium acts as an antioxidant, while at supra-nutritional high doses, selenium induces redox signaling and cell death.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Immunology

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

Shihao Xu et al.

Summary: The accumulation of lipids in the tumor microenvironment is associated with dysfunction of CD8(+) T cells, mediated in part by the CD36 receptor and its promotion of lipid uptake and peroxidation. Inhibiting p38 kinase or resolving lipid peroxidation may restore effector T cell functions and provide a potential therapeutic avenue for immunotherapies.

IMMUNITY (2021)

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Article Oncology

Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment

Francesca Valdemarin et al.

Summary: Our study demonstrates that periodic cycles of a modified fasting regime are feasible and safe in cancer patients at low nutritional risk, without negatively affecting body composition. Additionally, this fasting regime can reduce fat mass, insulin production, and circulating IGF1 and leptin levels in cancer patients.

CANCERS (2021)

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Article Endocrinology & Metabolism

Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice

Ana Teijeiro et al.

Summary: The study demonstrates that inhibiting the IL-17A axis can suppress diet-induced obesity and metabolic disorders, while promoting adipose tissue browning, thermogenesis, and energy expenditure. IL-17A also induces pathological changes in adipocytes, leading to obesity and metabolic syndrome.

NATURE METABOLISM (2021)

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Review Oncology

Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma

Amanda Garrido et al.

Summary: The liver, a major metabolic organ in the body, undergoes sophisticated mechanisms to repair and regenerate when damaged, with cirrhosis potentially being a protective response. Comprehensive population-based studies show a low risk of cirrhosis progressing to HCC.

TRENDS IN CANCER (2021)

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Review Endocrinology & Metabolism

Ketogenic diet in the treatment of cancer - Where do we stand?

Daniela D. Weber et al.

MOLECULAR METABOLISM (2020)

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Article Oncology

Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study

Adeleh Khodabakhshi et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2020)

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Article Nutrition & Dietetics

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial

James L. Dorling et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Cell Biology

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li et al.

CELL REPORTS (2020)

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Review Oncology

Dietary Approaches to Cancer Therapy

Mylene Tajan et al.

CANCER CELL (2020)

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Article Multidisciplinary Sciences

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

Maira Di Tano et al.

NATURE COMMUNICATIONS (2020)

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Review Nutrition & Dietetics

Nicotinamide Riboside-The Current State of Research and Therapeutic Uses

Mario Mehmel et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

Dae-Sung Hwangbo et al.

NUTRIENTS (2020)

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Review Multidisciplinary Sciences

Dietary modifications for enhanced cancer therapy

Naama Kanarek et al.

NATURE (2020)

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Review Biochemistry & Molecular Biology

Methionine Dependence of Cancer

Peter Kaiser

BIOMOLECULES (2020)

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Article Oncology

Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study

Stefanie Zorn et al.

BMC CANCER (2020)

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Article Oncology

ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma

Martin Voss et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

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Article Immunology

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

Teresa Manzo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Irene Caffa et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Fasting mimicking diet as an adjunct toneoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

Stefanie de Groot et al.

NATURE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

Jin He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

The Intestinal Microbiota and Colorectal Cancer

Yiwen Cheng et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade

Daniel Ajona et al.

NATURE CANCER (2020)

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Review Oncology

Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment

Ricardo Perez-Tomas et al.

CANCERS (2020)

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Article Oncology

A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma

Lisa Greene et al.

MOLECULAR CANCER RESEARCH (2019)

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Review Biochemistry & Molecular Biology

The microbiome, cancer, and cancer therapy

Beth A. Helmink et al.

NATURE MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression

Priya Bhardwaj et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

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Review Physiology

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release

Alyce M. Martin et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Article Multidisciplinary Sciences

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Xia Gao et al.

NATURE (2019)

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Article Endocrinology & Metabolism

Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial

Shaminie J. Athinarayanan et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Gastroenterology & Hepatology

Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study

Jiajia Zhang et al.

GUT (2019)

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Review Oncology

Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Fausto Petrelli et al.

CANCERS (2019)

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Article Nutrition & Dietetics

Vegetarian Diets: Planetary Health and Its Alignment with Human Health

Ujue Fresan et al.

ADVANCES IN NUTRITION (2019)

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Review Medicine, General & Internal

The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis

Yongin Cho et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Regulatory role of vitamin E in the immune system and inflammation

Erin Diane Lewis et al.

IUBMB LIFE (2019)

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Review Pharmacology & Pharmacy

The signaling pathways that mediate the anti-cancer effects of caloric restriction

Yiyi Lu et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Multidisciplinary Sciences

Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects

Francoise Wilhelmi de Toledo et al.

PLOS ONE (2019)

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Review Medicine, General & Internal

Effects of Intermittent Fasting on Health, Aging, and Disease

Rafael de Cabo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Pharmacology & Pharmacy

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

Ali F. Abdel-Wahab et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Multidisciplinary Sciences

Diet, Microbiota, and Colorectal Cancer

Tatiana P. Grazioso et al.

ISCIENCE (2019)

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Article Oncology

Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer

Mehmet Salih Iyikesici

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2019)

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Review Geriatrics & Gerontology

Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms

Valeria Tosti et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth

D. Ma et al.

ONCOGENE (2018)

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Article Oncology

The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld et al.

BMC CANCER (2018)

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Review Integrative & Complementary Medicine

Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting

John S. Finnell et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

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Article Oncology

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

Annemarie Schwab et al.

CANCER RESEARCH (2018)

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Article Cell Biology

mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

Marta Brandt et al.

CELL METABOLISM (2018)

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Article Cell Biology

Low-Protein Diet Induces IRE1 alpha-Dependent Anticancer Immunosurveillance

Camila Rubio-Patino et al.

CELL METABOLISM (2018)

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Article Endocrinology & Metabolism

Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20

Sounak Gupta et al.

ENDOCRINE PATHOLOGY (2018)

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Article Biochemistry & Molecular Biology

Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo

Jie Zhang et al.

JOURNAL OF LIPID RESEARCH (2018)

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Article Nutrition & Dietetics

A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer

Caroline W. Cohen et al.

JOURNAL OF NUTRITION (2018)

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Review Medicine, Research & Experimental

The influence of diet on anti-cancer immune responsiveness

Laura Soldati et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

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Article Multidisciplinary Sciences

Asparagine bioavailability governs metastasis in a model of breast cancer

Simon R. V. Knott et al.

NATURE (2018)

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Article Oncology

The Modified Ketogenic Diet in Adults with Glioblastoma: An Evaluation of Feasibility and Deliverability within the National Health Service

Kirsty J. Martin-McGill et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2018)

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Article Nutrition & Dietetics

A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice

Kentaro Nakamura et al.

NUTRIENTS (2018)

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Review Oncology

Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer

Xinqiang Wu et al.

JOURNAL OF CANCER (2018)

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Article Oncology

Association of Low-Fat Dietary Pattern With Breast Cancer Overall Survival A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trial

Rowan T. Chlebowski et al.

JAMA ONCOLOGY (2018)

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Article Cell Biology

The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome

Sen Shang et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)

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Article Multidisciplinary Sciences

Histidine catabolism is a major determinant of methotrexate sensitivity

Naama Kanarek et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Benjamin D. Hopkins et al.

NATURE (2018)

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