Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification

This review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily conserved gene regulatory networks (GRNs) that specify early- and late-state retinal progenitor cells (RPCs) and neurogenic progenitors and that control the final steps in determining cell identity. Finally, we discuss findings that provide insight into regulation of speciesspecific aspects of retinal patterning and neurogenesis, including consideration of key outstanding questions in the field.

Automated summary

This review provides insights into the recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on comparative single cell multiomic analysis. It discusses the mechanisms by which extrinsic factors trigger transcriptional changes and the core evolutionarily conserved gene regulatory networks that influence retinal progenitor cells and neurogenesis.