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Article
Agriculture, Multidisciplinary
Kang Chen et al.
Summary: Anthocyanins with acylated moieties have different effects on diabetes compared to nonacylated anthocyanins due to their improved stability and probiotic-like properties. This study highlights the recent findings on the antidiabetic effects of acylated anthocyanins, focusing on their modulation of energy metabolism, inflammation, and gut microbiota. The cellular and molecular mechanisms associated with the beneficial effects of these structurally different anthocyanins provide new insights into their potential therapeutic applications in type 2 diabetes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Chun Xiao Li et al.
Summary: The impact of phenolic compounds on the human body depends on their type, content, bioavailability, and antioxidant activity. Different phenolic compounds undergo varied changes in bioavailability and antioxidant activity after digestion, which should be taken into consideration in their application.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Integrative & Complementary Medicine
Mohd Hafizur Rehman Ansari et al.
Summary: The gut microbiota plays a role in the metabolism of drugs, especially dietary natural compounds. Herbal medicines, when orally administered, can be altered by gut microbiota metabolism and have implications for specific ailments. This review discusses the interactions between different natural compounds and gut microbiota, and their biological significance in rodent-based models.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Review
Nutrition & Dietetics
Hao Zhong et al.
Summary: With the increase in human mean age, the prevalence of neurodegenerative diseases (NDs) also rises. Anthocyanins have been found to regulate the functioning of the central nervous system (CNS) through the microbiome-gut-brain axis, providing a new perspective for treating NDs. This review summarizes the protective effects and mechanisms of anthocyanins against NDs, focusing on their interaction with the intestinal microbiota and the microbial-intestinal-brain axis system.
Review
Food Science & Technology
Roxana Banc et al.
Summary: Ellagitannins (ETs), found in plant-source foods, have been associated with positive effects on various pathologies. However, their limited bioavailability hinders their systemic circulation, while urolithins, ET metabolites, are better absorbed and may be responsible for the bioactive effects. This review examines the dietary sources, metabolism, and bioavailability of ETs, as well as the recent findings on their activities, potential mechanisms, and the connection with the gut-brain axis. Current studies suggest that ET-rich foods, gut microbiomes, or urolithin types can modulate signaling pathways and promote beneficial health effects.
Article
Chemistry, Applied
Jia-Jia Wen et al.
Summary: Tea polyphenol (TP) and epigallocatechin gallate (EGCG) can improve hyperlipidemia and liver fat accumulation by regulating gut microbiota and promoting gut health.
Article
Agriculture, Multidisciplinary
Carlos E. Iglesias-Aguirre et al.
Summary: We discovered a new bacterium in the feces of a healthy woman that can produce urolithins A and B as well as intermediate metabolites. Additionally, we developed co-culture systems that reproduced the production of urolithins upon fermentation of UM-A and UM-B. This finding demonstrates the potential of these urolithin-producing bacteria for use as probiotics and in the production of bioactive urolithins for various applications.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Vikram Patial et al.
Summary: Obesity is a global epidemic and a major risk factor for chronic kidney disease. This study investigated the preventive effect of green tea catechins (GTC) on obesity-induced kidney damage and identified the molecular mechanism involved. In vitro experiments demonstrated that GTC treatment reduced fat accumulation and modulated the expressions of key molecules in fat metabolism in cultured kidney cells. In vivo experiments in rats fed a high-fat diet showed that GTC treatment significantly reduced weight gain and improved markers of kidney function. GTC also improved insulin sensitivity and reduced kidney tissue damage. Furthermore, GTC treatment promoted the growth of beneficial gut bacteria and improved gut health and metabolism. Overall, GTC prevented obesity-induced kidney damage by modulating specific signaling pathways and maintaining gut health.
Review
Plant Sciences
M. Boix-Castejon et al.
Summary: Food intake behavior is influenced by physiological and psychological processes, and the neuroendocrine regulation of food intake involves signals that modulate appetite, satiety, and hunger. Natural plant compounds are being studied for their potential in appetite control, but the research lacks conclusive physiological data, such as anthropometric evaluations and hormone analysis. More systematic clinical studies are needed to decode the hormone patterns regulating hunger and satiety and to correlate brain connectivity with appetite and satiety.
Article
Food Science & Technology
Mubai Sun et al.
Summary: This study investigated the therapeutic mechanism of black bean peel anthocyanin extract on type 2 diabetes mellitus (T2DM) by examining the gut microbiota and serum metabolome. The results showed that the extract improved blood glucose levels, reduced oxidative stress and inflammation, and alleviated lipid metabolism disorders in T2DM rats. The abundance of certain gut bacteria increased, and specific metabolites were elevated in the serum. Furthermore, the extract regulated the expression of key genes responsible for T2DM and lipid metabolism. These findings provide a new therapeutic direction for T2DM treatment.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Jihong Zhou et al.
Summary: Green tea catechin epigallocatechin gallate (EGCG) can alleviate obesity and regulate intestinal inflammation and hypothalamic neurotransmitters. EGCG significantly reduces body weight, fat accumulation, and liver steatosis, modulates neurotransmitters such as dopamine and 5-HTP, attenuates colonic inflammatory factors and barrier damage, increases gut microbial abundance, reduces short-chain fatty acids, and downregulates transcription factors.
Review
Cell Biology
Adam Jedrusiak et al.
Summary: This review focuses on the influence of bacteriophages on the central nervous system. It explores the link between bacteriophages in the gut microbiota and the gut-brain axis network, as well as their potential therapeutic applications in treating brain and neural diseases.
Article
Pharmacology & Pharmacy
Sanmuga Priya Ekambaram et al.
Summary: This study evaluated the anti-inflammatory potential of hydrolysable tannin fraction (HTF) derived from Terminalia chebula fruit pericarps in LPS-induced RAW 264.7 cells, and compared it with individual tannins. The results showed that HTF could decrease the release of NO, ROS, and cytokines by inhibiting NF-kappa B and MAPK signaling pathways.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Review
Neurosciences
D. C. Lacerda et al.
Summary: This review evaluates the metabolic and neurological effects of polyphenols-based treatment in rodent models of NCDs, showing that polyphenols can attenuate changes in energy balance and body weight, and are associated with neuroprotective responses.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Neurosciences
Adrian L. Lopresti et al.
Summary: The study systematically reviewed the effects of plants or phytonutrients on HPA-axis related hormones in human trials. The results showed that the effects of supplementation on HPA-axis activity in humans is unclear for most phytonutrients. Further research is needed to make more definitive conclusions about the effects of phytonutrients on the HPA-axis.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Food Science & Technology
Yu Wang et al.
Summary: This study found that parsley has significant anti-fatigue effects, which can be attributed to its flavonoids. The flavonoids in parsley regulate oxidative stress and exert an anti-fatigue effect by regulating specific pathways. Additionally, the intake of flavonoids stimulates the growth of beneficial microbiota and short chain fatty acid producing bacteria, which are involved in energy metabolism and fatigue regulation.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Nutrition & Dietetics
Mostafa Hassan Baky et al.
Summary: Flavonoids are natural polyphenol secondary metabolites widely found in plants and in human diets, exhibiting numerous health benefits. Their interactions with gut microbiota play a crucial role in influencing physiological activities and inducing measurable biological changes and benefits. Understanding these interactions is key to comprehensively grasping the impact of flavonoids on human health.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Medicine, Research & Experimental
Li Zeng et al.
Summary: This review comprehensively explores the regulatory role and mechanism of chlorogenic acid (CGA) in the intestine and brain, as well as its potential biological actions in the gut-brain axis. It provides a scientific foundation for CGA research in the brain and intestines and promotes the translation of basic research and the application of CGA in food nutrition and healthcare.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Applied
Wanjun Ma et al.
Summary: The study demonstrated that different post-fermentation processes have significant effects on the hypolipidaemic and antioxidant effects of dark teas, with Liu Bao tea and Pu-erh tea showing promising hypolipidaemic potential while experiencing a decrease in antioxidant capacity.
Review
Biochemistry & Molecular Biology
Mengyu Hong et al.
Summary: The interactions between tea polyphenols (TP) and intestinal microbiota play a significant role in ameliorating neurological diseases and enhancing host immunity. Based on the bidirectional relationship between the brain and the intestines, TP shows promise in improving host health through modulating intestinal bacteria.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Moyad Shahwan et al.
Summary: Compromised carbohydrate metabolism leading to hyperglycemia is the primary metabolic disorder of non-insulin-dependent diabetes mellitus. Polyphenolic compounds play an important role in regulating insulin resistance and carbohydrate metabolism through inhibiting key enzymes and activating specific pathways to control blood glucose levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Tekleab Teka et al.
Summary: This review provides a comprehensive overview of Stilbene's botanical sources, chemistry, biosynthetic pathways, pharmacology, and clinical applications and challenges.
Article
Microbiology
Silvia Molino et al.
Summary: The Western diet, characterized by high fat and sugar content and low vegetable intake, disrupts the gut microbiota and contributes to inflammation-related chronic diseases. Supplementing with a blend of natural tannin extracts can positively influence the composition and functionality of the gut microbiota, increasing microbial diversity and promoting the growth of beneficial bacteria, thereby exerting anti-inflammatory effects.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Jiayan Xie et al.
Summary: This study found that mung bean coat is a good source of dietary polyphenols, which can be released through colonic fermentation and contribute to antioxidant capacity. The polyphenols in mung bean coat can also improve the abundance of beneficial bacteria and promote the synthesis of short-chain fatty acids (SCFAs), thereby promoting gut health.
Article
Food Science & Technology
Ruonan Yan et al.
Summary: This article reviews the relationship between the host's circadian rhythm and microbiota and its influence on metabolic diseases, emphasizing the beneficial effects of the interaction between tea polyphenols and gut microbiota.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Meiyan Wang et al.
Summary: Tea polyphenols, as an abundant source of naturally occurring polyphenols, have received increasing attention for their consumption and pleiotropic bioeffects on human health. The bidirectional interactions between tea polyphenols and gut microbiota may benefit gut barrier function and improve chronic metabolic disorders.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Biochemistry & Molecular Biology
Natalia Drabinska et al.
Summary: Plant-based nutraceuticals, particularly phenolic compounds, are gaining attention for their anti-inflammatory and antioxidant activities. Resveratrol, a polyphenol, shows potential in improving gut barrier integrity, but further clinical trials are needed for validation of its effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Baoming Tian et al.
Summary: Ferulic acid (FA) mitigates obesity by modulating the gut microbiota (GM), improving intestinal barrier function, and reducing inflammation. FA increases the abundance of short-chain fatty acid (SCFA)-producing bacteria and reduces the abundance of endotoxin-producing bacteria, resulting in decreased levels of endotoxin. Therefore, modulation of the GM by FA may be a promising approach to combat obesity.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Wenwen Cheng et al.
Summary: Tartary buckwheat flavonoids (TBFs) have various biological activities, including improving glucose and lipid disturbances and preventing diabetes-related colon lesions in mice. TBFs also regulate the composition of the gut microbiota, increasing beneficial bacteria and decreasing diabetes-related microbiota.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Food Science & Technology
Luyao Chen et al.
Summary: Polyphenols, secondary plant metabolites widely found in diets, have antagonistic effects on chronic metabolic diseases such as type 2 diabetes (T2D) and obesity. They exert their effects by protecting pancreatic beta-cells, affecting glucose digestion and uptake, and activating metabolism pathways. The relationship between polyphenols, T2D, and obesity is complex, as polyphenols can improve obesity-induced insulin resistance while obesity decreases polyphenols bioavailability. Exploiting polyphenols in the food industry, such as masking bitter taste and improving stability and bioavailability, has significant value in anti-diabetic and anti-obesity applications.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Thais Borges Cesar et al.
Summary: This study found that Eriomin can effectively reduce hyperglycemia and improve diabetes-related biomarkers. Intervention with Eriomin increases GLP-1 levels and decreases systemic inflammation, benefiting individuals with poor blood glucose control in prediabetic and diabetic conditions.
JOURNAL OF MEDICINAL FOOD
(2022)
Review
Cell Biology
Giovanni Cirillo et al.
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Food Science & Technology
Bowei Zhang et al.
Summary: Dietary polyphenol intake has beneficial effects on human health, but the high interindividual variability in response to polyphenol consumption can impact the final evaluation of clinical outcomes. The metabolism and absorption of polyphenols play a key role in their health effects, and personalized nutrition based on individualized metabolic patterns can help capture the health benefits of dietary polyphenols.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Chemistry, Medicinal
Lijie Su et al.
Summary: Quercetin supplementation can reduce inflammation in obese mice induced by a high-fat diet by altering gut microbiota and metabolites.
PHYTOTHERAPY RESEARCH
(2022)
Review
Food Science & Technology
Gabriela Paz Pizarro Melendez et al.
Summary: Mental health is a global concern, with anxiety and psychological stress being common disorders. Dietary polyphenols have the potential to have an impact on anxiety and stress, although the evidence is currently limited.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
Ting Xia et al.
Summary: Polyphenols in vinegar have beneficial effects on human health, particularly in relieving symptoms of type 2 diabetes mellitus. Vinegar extract can regulate blood glucose, reduce inflammation, and restore gut microbiota balance, thereby exerting anti-diabetic effects.
Article
Chemistry, Applied
Ruimin Wang et al.
Summary: In this study, the researchers investigated the mitigative effect of Rhodomyrtus tomentosa fruit extract rich in phenolic compounds on high fat diet-induced intestinal barrier dysfunction. The results showed that the extract improved gut microbiota dysbiosis, reduced harmful bacteria, and increased beneficial bacteria. Additionally, it helped to improve intestinal barrier function and reduce inflammation by regulating protein expression levels and suppressing proinflammatory cytokines. These findings suggest that Rhodomyrtus tomentosa fruit extract supplementation may be an effective way to protect the intestine in obese individuals on a high fat diet.
Article
Agriculture, Multidisciplinary
Carlos E. Iglesias-Aguirre et al.
Summary: We report the discovery of two metabotypes associated with resveratrol metabolism by the human gut microbiota: LUNU (lunularin) producers and LUNU non-producers. The LUNU-producer metabotype can sequentially dehydroxylate resveratrol to yield LUNU and 4-hydroxydibenzyl, while the LUNU non-producer metabotype lacks this ability. These metabolites were detected in the urine and (or) feces of the majority of volunteers, but around 26% lacked the corresponding enzyme activity. Both metabotypes possess a 4-styrylphenol reductase that converts resveratrol to its corresponding dibenzyl.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Bowei Zhang et al.
Summary: Resveratrol and its microbial metabolite 4-hydroxyphenylpropionic acid have protective effects against intestinal barrier damage and colitis by upregulating tight junction proteins and restoring the expression of Muc2.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Vemana Gowd et al.
Summary: Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation in the digestive tract. The exact cause of IBD is unknown, and current treatments using synthetic drugs and monoclonal antibodies have limitations. Resveratrol, a natural polyphenol, has been shown to have therapeutic effects against IBD by targeting multiple molecular pathways. However, its therapeutic application is hindered by its low water solubility and limited bioavailability. Encapsulation and controlled release of resveratrol using different carriers have emerged as a promising strategy to overcome these limitations.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jing-Ya Cao et al.
Summary: Five new arylnaphthalide lignans and five known analogues were isolated from Saussurea medusa. Compound 4 was characterized as an unusual aryltetralin lignan with a unique oxygen bridge group. The structures of the new compounds were determined using spectroscopic and electronic circular dichroism calculations. These compounds were isolated for the first time from S. medusa and had not been previously identified in the Saussurea genus. The anti-inflammatory activities of the compounds were evaluated, and two compounds showed significant inhibitory effects.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Maria Lucia da Silva Cordeiro et al.
Summary: This article introduces depression and the limitations of pharmacological treatment. The study suggests that phenolic acids from medicinal plants and their extracts have the potential to reduce depressive symptoms and modulate multiple molecular pathways associated with depression.
Article
Chemistry, Applied
Kang Yang et al.
Summary: This study found that long-term consumption of Gallic acid (GA) has beneficial effects on lipid metabolism and gut health, with 0.08% GA supplementation showing the best results.
Review
Pharmacology & Pharmacy
Muhammad Ajmal Shah et al.
Summary: Obesity-associated diabetes mellitus is a serious health issue affecting a large number of people worldwide. Synthetic drugs currently used to treat diabetes have limitations and severe side effects. Plant-derived phytochemicals, particularly dietary polyphenols, are being explored as potential alternatives due to their ability to address both diabetes and obesity with fewer side effects and toxicity.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Integrative & Complementary Medicine
Xia Huan et al.
Summary: Two new neolignans and one new lignan were isolated from the roots of Paeonia lactiflora. Their structures were determined using various spectroscopic techniques, X-ray crystallography, and electronic circular dichroism. One of the compounds exhibited moderate inhibitory activity against human carboxylesterase 2A1.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Multidisciplinary
Jing-Ya Cao et al.
Summary: Five new arylnaphthalide lignans were isolated from Saussurea medusa, some of which showed significant anti-inflammatory activities by inhibiting NO production.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Food Science & Technology
Murphy L. Y. Wan et al.
Summary: Polyphenols, abundant in plants, are powerful antioxidants in the human diet, influencing gut health through modulation of various pathways and gut microbiota composition. Further research is needed to elucidate the mechanisms and potential benefits in preventing or treating diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Nutrition & Dietetics
Suman Kumar Ray et al.
Summary: Polyphenols, as natural plant compounds with antioxidant, antimicrobial, and anticarcinogenic activities, play a crucial role in gut ecology and human health. Their impact on intestinal biology adaptation and the two-way relationship with microbiota remains poorly understood.
FRONTIERS IN NUTRITION
(2021)
Review
Endocrinology & Metabolism
Marziyeh Najafi et al.
Summary: This systematic review aimed to summarize the effects of Resveratrol on Sirt1 expression, showing beneficial effects on protein and gene expression of SIRT1.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Review
Microbiology
Yong Fan et al.
Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Jianhui Liu et al.
Summary: The study showed that anthocyanin extracts from blueberry and cranberry could reduce body weight and modulate gut microbiota favorably in mice.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Zhibin Liu et al.
Summary: The study found that Theaflavin-3,3'-digallate (TFDG) undergoes a significantly different microbial metabolic fate in human gut microbiota compared to epigallocatechin gallate (EGCG), yet both have similar modulatory effects on gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yuting Zhang et al.
Summary: Tea polyphenols (TP) are important functional components in tea, regulating human intestinal flora and being bio-transformed by intestinal microbiota into beneficial metabolites that protect nerves and promote neurocognition. Research highlights the significance of TP in protecting cerebral nerves through its effects on intestinal microflora and microbial degradation. Understanding the interaction between TP and intestinal microbiota, its implications for cerebral nerve protection, and the underlying mechanism can expand therapeutic applications of TP.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Jiangxiong Zhu et al.
Summary: This study found that Liubao tea extract has a positive impact on metabolic disorders and intestinal flora dysbiosis in hyperglycemic mice, which can improve insulin resistance and activate related signaling pathways.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Yuka Kawakami et al.
Summary: This study suggests that consuming cocoa polyphenol-rich chocolate in healthy individuals can decrease plasma glucose concentrations at 120 minutes postprandially, while increasing insulin and GLP-1 secretion. Cocoa polyphenol-rich chocolate shows potential in managing postprandial glucose excursions.
Review
Nutrition & Dietetics
Umair Shabbir et al.
Summary: Polyphenols are naturally occurring bioactive components in fruits and vegetables, playing a role in improving metabolic syndromes and preventing chronic diseases by influencing the composition of gut microbiota. Various approaches have been developed to improve the bioavailability of polyphenols in the gut.
Article
Agriculture, Multidisciplinary
Wenyan Xian et al.
Summary: This study reported the distribution of urolithin metabotypes in Chinese youth and found differences in richness and diversity of gut microbiota among the three metabotypes. The abundance of Gordonibacter and presence of Akkermansia varied significantly among different metabotypes. Correlation analysis showed associations between urolithin types and gut microbiota at the genus level. Further research is needed to explore the mechanisms and health implications of these metabotypes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Haizhao Song et al.
Summary: This study demonstrated that supplementation of blackcurrant anthocyanins (BCA) could prevent HFD-induced obesity by targeting microbiota.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yao Wang et al.
Summary: Type 2 diabetes is a global health issue caused by insulin resistance and pancreatic beta-cell dysfunction. The gastrointestinal tract is an important regulator of glucose homeostasis, with the incretin hormone GLP-1 playing a key role in maintaining glucose balance. Polyphenols from plants have potential anti-diabetic effects by stimulating GLP-1 secretion.
Article
Food Science & Technology
Lin Feng et al.
Summary: The study found that QZT extract can significantly prevent weight gain and fat accumulation, while also reducing serum levels of total cholesterol and triglycerides. This is accompanied by changes in the Firmicutes-to-Bacteroidetes ratio and the relative abundance of S24-7 and Ruminococcaceae in the gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Malgorzata Makarewicz et al.
Summary: This review provides a comprehensive understanding of the bidirectional relationship between polyphenols and the gut microbiome, including the impact of polyphenols on microorganisms and the biotransformation of polyphenols by bacteria. The interactions between polyphenols and gut microbiota play a crucial role in human health.
Article
Medicine, Research & Experimental
Hui-Hui Xiao et al.
Summary: The study demonstrated that oral administration of lignan-rich fraction from S. williamsii improved dyslipidemia, liver functions, glucose tolerance, insulin actions, and intestinal barrier in OVX rats, while inducing an increase in Actinobacteria abundance and restoration of microbial composition. These findings suggest the potential application of this lignan-rich fraction in treating menopausal lipid disorders and insulin resistance-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Tina Nie et al.
Summary: Polyphenolic compounds show promise in treating type 2 diabetes by inhibiting hA aggregation and modulating oxidative stress and inflammation pathways that affect beta-cell disruption. Further research is needed to determine their potential as a therapeutic option for T2DM.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jingze Huang et al.
Summary: Curcumin has been shown to improve intestinal health, insulin resistance, and blood sugar levels in diabetic rats. It protects the intestinal mucosal barrier, reverses gut microbiota dysbiosis caused by high-fat diet, and provides experimental evidence for the prevention and treatment of type 2 diabetes mellitus.
Article
Chemistry, Applied
Lorena Calderon-Perez et al.
Summary: This study identified potential associations between dietary phenolic compounds (PCs), gut microbiota composition, and targeted faecal metabolites, highlighting the role of specific PCs as gut microbiome modulators in either the pathogenesis or prevention of hypertension in hypertensive (HT) and normotensive (NT) subjects.
Article
Microbiology
Silvia Molino et al.
Summary: The study showed that foods enriched with tannin extracts can effectively increase the abundance of beneficial bacteria Akkermansia and promote the production of short chain fatty acids (SCFAs) without altering the characteristics of the foods themselves.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuyan Gu et al.
Summary: Ferulic acid (FA) can significantly alleviate atherosclerotic injury in mice by modulating lipid metabolism and gut microbiota. This improvement may be partly achieved through the AMPK alpha/SREBP1/ACC1 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Microbiology
Ibrahim E. Sallam et al.
Summary: Tannins, a diverse group of polyphenols found in various plant families, especially cereals, fruits, and vegetables, have beneficial pharmacological effects, including anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective properties. Microbiota-mediated hydrolysis of tannins generates highly bioaccessible metabolites, which contribute to the health effects associated with tannin consumption. Understanding the interactions between microbiota and tannins, as well as the metabolism and chemical motifs of tannin metabolites, is crucial for utilizing their biological effects for drug discovery and promoting health benefits.
Article
Chemistry, Applied
Bowei Zhang et al.
Summary: This study investigated the intestinal pharmacokinetics of resveratrol in mice using HPLC-MS/MS and found that resveratrol and its metabolites were present in significant amounts in the entire intestinal tract and feces, with a peak concentration at 4 hours post-administration. The study also demonstrated the promotion of Lactobacillus reuteri growth by resveratrol-3-O-sulfate during in vitro fermentation and the up-regulation of tight junction and mucin-related proteins mRNA expressions by resveratrol-3-O-sulfate during incubation with Caco-2 cells.
Review
Agriculture, Multidisciplinary
Hanieh Nargeh et al.
Summary: Neurodegenerative diseases are a significant public health challenge due to their association with aging. Understanding the molecular and cellular mechanisms involved in their pathogenesis is crucial. Protein aggregations resulting from UPS inefficiency and gut microbiota alternations are key pathogenic features, with polyphenols potentially playing a role in decreasing disease development rates. The conversion of dietary polyphenols into different microbial metabolites with diverse biological properties highlights the need for thorough investigation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Ruiqian Duan et al.
Summary: Whole-grain oat flavonoids can improve hyperlipidemia induced by high-fat diet by regulating lipid metabolism, promoting bile acid synthesis, and enhancing the efflux of fat through the FXR pathway. Additionally, they can significantly alter the composition of gut microbiota, reducing harmful bacteria and increasing beneficial bacteria.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Zhicheng Zhang et al.
Summary: Tea polyphenols may exert neuroprotective effects by regulating intestinal microbiota and their metabolites, with the microbiota-gut-brain axis playing a critical role in this process.
Article
Nutrition & Dietetics
Haizhao Song et al.
Summary: The study demonstrated that the anthocyanin-rich extract of acai alleviated obesity, hepatic steatosis, and insulin resistance induced by high-fat diet in mice. Furthermore, changes in gut microbiota, particularly enrichment of Akkermansia muciniphila, were associated with the antiobesity effects of acai extract.
Article
Food Science & Technology
Estefania Sanchez-Rodriguez et al.
Summary: This study evaluated the postprandial effects of virgin olive oils enriched with bioactive compounds from the olive fruit on plasma glucose, insulin, and gastrointestinal hormones responses in healthy adults. The findings suggest that olive oil enriched with triterpenes can reduce insulin release, while olive oil with high polyphenol content can lower plasma glucose levels and improve insulin sensitivity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Yuqing Tan et al.
Summary: Quercetin supplementation in high-fat diet-fed mice led to reduced body weight, liver weight, and adipose weight, as well as lower liver lipid and blood glucose levels. It also significantly lowered diabetes-related plasma biomarkers and altered the gut microbiome composition. Additionally, quercetin supplementation downregulated the expression of genes associated with metabolism.
Meeting Abstract
Nutrition & Dietetics
R. A. G. Pushpass et al.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Haizhao Song et al.
Summary: The study demonstrated the protective effects of dietary supplementation of BRAN against obesity-associated hyperlipidemia, hepatic steatosis, and insulin resistance by modulating the gut microbiota and lipid metabolism.
Review
Biochemistry & Molecular Biology
Carlos E. Iglesias-Aguirre et al.
Summary: Despite high variability in individual response to (poly)phenol consumption, causal relationships between dietary (poly)phenols and health effects have been established. Various factors affecting this variability have been identified, but the final drivers for these health effects remain unclear. Potential drivers include the effects of ingested (poly)phenols in the gastrointestinal tract, bioavailable metabolites, and gut microbial ecology associated with (poly)phenol metabolism.
Article
Integrative & Complementary Medicine
Chen Cheng et al.
Summary: Honokiol, the dominant biphenolic compound isolated from the Magnolia tree, is widely regarded as the active constituent of the traditional Chinese herb 'Houpo'. It possesses a wide range of bioactivities such as anti-inflammatory, antioxidant, anti-obese, anti-diabetic, and anti-cancer properties.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Zhen Shi et al.
Summary: The study demonstrates that Nuciferine (NF) reduces intestinal permeability in obese mice by improving autophagy and alters the composition of gut microbiota.
Review
Biochemistry & Molecular Biology
Qiaoyu Sun et al.
Summary: Tea polyphenols, as the most bioactive components in tea extracts, can regulate the composition and function of the intestinal flora, improve human health by utilizing intestinal microorganisms and their metabolites, and potentially prevent psychiatric disorders through modulating the host intestinal microorganisms.
Review
Food Science & Technology
William Leonard et al.
Summary: Hydroxycinnamic acids (HCAs) are a major class of phenolic acids with a characteristic phenylpropanoid C-6-C-3 backbone. Despite being typically conjugated with plant cell wall components and liberated by limited enzymes, HCAs have been neglected by researchers compared to flavonoid-type polyphenols. Recently, there has been a growing interest in the interactions between polyphenols and gut microbiota, with significant progress in understanding the gut microbiota-modulating effect of HCA using animal model studies.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Review
Nutrition & Dietetics
Andreia Bento-Silva et al.
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Microbiology
Jinshui Zheng et al.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Review
Food Science & Technology
Nurhan Unusan
JOURNAL OF FUNCTIONAL FOODS
(2020)
Review
Nutrition & Dietetics
Rima M. Chakaroun et al.
Review
Microbiology
Shu-Zhi Wang et al.
Article
Microbiology
Yinzhao Zhong et al.
Review
Nutrition & Dietetics
Melissa J. Banez et al.
NUTRITION RESEARCH
(2020)
Review
Chemistry, Medicinal
Luce M. Mattio et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Food Science & Technology
Wanbing Chen et al.
FOOD RESEARCH INTERNATIONAL
(2020)
Review
Nutrition & Dietetics
Vincenzo Sorrenti et al.
Article
Agriculture, Multidisciplinary
Zhibin Liu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Food Science & Technology
Juan Kan et al.
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Pharmacology & Pharmacy
Ting-Ting Cai et al.
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Integrative & Complementary Medicine
Zirong Deng et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Review
Nutrition & Dietetics
Hasmiza Halib et al.
Review
Geriatrics & Gerontology
Ji Yeon Chung et al.
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Review
Endocrinology & Metabolism
Qi Zhang et al.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Food Science & Technology
Yuan Song et al.
FOOD RESEARCH INTERNATIONAL
(2020)
Review
Agriculture, Dairy & Animal Science
Takuya Suzuki
ANIMAL SCIENCE JOURNAL
(2020)
Review
Food Science & Technology
Aline Medeiros Alves-Santos et al.
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Food Science & Technology
Jia Xu et al.
JOURNAL OF FUNCTIONAL FOODS
(2020)
Review
Biochemistry & Molecular Biology
Martha A. Schalla et al.
Article
Biochemistry & Molecular Biology
Tala Shi et al.
Review
Food Science & Technology
Gizem Catalkaya et al.
Article
Biochemistry & Molecular Biology
Yuxin Cheng et al.
Article
Biochemistry & Molecular Biology
Ruihong Dong et al.
Article
Biochemistry & Molecular Biology
Rocio Garcia-Villalba et al.
Review
Endocrinology & Metabolism
Douglas Edward Barre et al.
CURRENT DIABETES REVIEWS
(2020)
Article
Multidisciplinary Sciences
F Bäckhed et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2004)
