The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1

Article Medical Laboratory Technology

CircSamd4: A novel biomarker for predicting vascular calcification

Yuting Zhou et al.

Summary: The study found that circSamd4a exhibited a stable downward trend in different specimens, and showed significant advantages as a biomarker for the diagnosis of VC.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Chemistry, Multidisciplinary

Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis

Tian-yu Li et al.

Summary: Abnormal activation of cardiac fibroblasts is the main cause of cardiac fibrosis. This study reveals the important roles of platelet-activating factor (PAF) and the Hippo pathway in cardiac fibrosis. PAF induces fibrosis through activation of the effector YAP1 and promotes its nuclear translocation via PAFR interaction. Furthermore, YAP1 promotes the expression of PAFR. Inhibiting PAFR or YAP1 can impede cardiac fibrosis and improve cardiac function. These findings suggest the potential of PAFR/YAP1 as therapeutic targets for cardiac fibrosis.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Pharmacology & Pharmacy

Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway

Jiangcheng Shu et al.

Summary: This study reveals that daidzein has an anti-fibrotic effect in myocardial fibrosis by reducing the activation of cardiac fibroblasts induced by TGF-beta 1, partially through regulating the TGF-beta 1/SMAD2/3 signaling pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Circular RNAs in physiology and non-immunological diseases

Liang Chen et al.

Summary: Circular RNAs (circRNAs) are covalently closed single-stranded RNAs with unique features in their biogenesis, degradation, and transport. They have diverse molecular functions, including sponging miRNAs, regulating transcription, modulating RNA-binding proteins, and even encoding proteins. Dysregulation of circRNAs is associated with various human disorders. Further research can help resolve debates and potentially lead to biomedical applications of circRNAs.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

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Article Medicine, Research & Experimental

CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis

Xianping Long et al.

Summary: Myocardial infarction is a leading cause of death and disability worldwide. This study found that circERBB2IP is highly expressed in the heart and can promote angiogenesis after myocardial infarction through the miR-145a-5p/Smad5 axis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Biotechnology & Applied Microbiology

YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization

Nan Wu et al.

Summary: Cardiac fibrosis is associated with circular RNA circYap, which modulates fibrosis by regulating the interaction between TMP4 and ACTG, potentially serving as a new target for cardiac therapy in the future.

MOLECULAR THERAPY (2021)

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Article Oncology

Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer

Jiehua He et al.

Summary: This study found that circHERC4 was significantly upregulated in colorectal cancer tissues, associated with lymph node metastasis and advanced tumor grade, and correlated with worse survival. Silencing circHERC4 inhibited proliferation and migration of aggressive CRC cell lines and reduced metastasis in vivo. Mechanistically, circHERC4 inactivated the tumor suppressor miR-556-5p, leading to activation of the CTBP2/E-cadherin pathway promoting tumor metastasis in CRC.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p

Dong-Liang Chen et al.

Summary: The study highlights the upregulation of circDLG1 in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy, correlating with aggressive tumor phenotype and poor prognosis. Ectopic circDLG1 expression promotes proliferation, migration, invasion, and immune evasion of gastric cancer cells. Mechanistically, circDLG1 interacts with miR-141-3p as a miRNA sponge to increase CXCL12 expression, promoting gastric cancer progression and resistance to anti-PD-1 therapy.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

Tao Jiang et al.

Summary: The study demonstrates that upregulation of circIL4R in CRC plays an oncogenic role by promoting CRC cell proliferation, migration, and invasion through activation of the PI3K/AKT signaling pathway. Targeting circIL4R may serve as a potential diagnostic and prognostic biomarker for CRC detection and treatment.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis

Shenglong Li et al.

Summary: The study revealed that circDOCK1 promotes progression and regulates cisplatin sensitivity in osteogenic sarcoma (OS) via the miR-339-3p/IGF1R axis. This indicates that the circDOCK1/miR-339-3p/IGF1R axis may be a key mechanism and potential therapeutic target in OS.

MOLECULAR CANCER (2021)

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Article Immunology

LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury

Xiaohua Zhu et al.

Summary: The study revealed that lncRNA CRNDE can regulate YAP1 level through ubiquitination and proteasomal degradation pathway, thereby inhibiting cardiomyocytes apoptosis in MI/R injury.

AUTOIMMUNITY (2021)

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Article Cell Biology

Epigenetic Repression of Chloride Channel Accessory 2 Transcription in Cardiac Fibroblast: Implication in Cardiac Fibrosis

Tinghui Shao et al.

Summary: The study investigated the transcriptional regulation mechanism of Clca2 in cardiac fibrosis, revealing that the Twist1-HDAC1 complex can suppress the expression of Clca2 in cardiac fibroblasts, potentially leading to FMyT and cardiac fibrosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes

Na Wu et al.

Summary: Our study revealed that mmu_circ_0005019 plays a protective role in the development of atrial fibrillation by regulating the miR-499-5p/Kcnn3 pathway.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Cardiac & Cardiovascular Systems

CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart

Yu Bian et al.

Summary: The study revealed that circHelz, a circRNA transcribed from the Helz gene, is significantly upregulated in ischemic myocardium and cardiomyocytes exposed to hypoxia. The overexpression of circHelz triggers NLRP3 inflammasome activation and pyroptosis, while silencing circHelz reduces these effects. Additionally, circHelz knockdown attenuates inflammasome expression, reduces myocardial injury and improves cardiac function after MI. Overexpression of miR-133a-3p prevents pyroptosis by targeting NLRP3, and circHelz functions as a sponge for miR-133a-3p. Ultimately, interfering with the circHelz/miR133a-3p/NLRP3 axis may be a promising therapeutic strategy for ischemic cardiac diseases.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

Jiaqi Wang et al.

Summary: The study revealed that circSPARC is upregulated in CRC patients and is associated with tumor progression and survival rates. Silencing circSPARC can inhibit CRC cell migration and proliferation. CircSPARC interacts with miR-485-3p to upregulate JAK2 expression, leading to the accumulation of p-STAT3.

MOLECULAR CANCER (2021)

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Review Biochemistry & Molecular Biology

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Chen Xue et al.

Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Calcium -Sensing Receptor on Neutrophil Promotes Myocardial Apoptosis and Fibrosis After Acute Myocardial Infarction via NLRP3 In flammasome Activation

Ziqi Ren et al.

CANADIAN JOURNAL OF CARDIOLOGY (2020)

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Article Cell Biology

Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis

Ernesto Canalis et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Medicine, Research & Experimental

STIM1 controls calcineurin/Akt/mTOR/NFATC2-mediated osteoclastogenesis induced by RANKL/M-CSF

Yanjiao Huang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Cell Biology

Integration of Hippo-YAP Signaling with Metabolism

Consuelo Ibar et al.

DEVELOPMENTAL CELL (2020)

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Article Oncology

Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma

Xiangxiang Zhou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Medicine, Research & Experimental

Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

Mark Sweeney et al.

EMBO MOLECULAR MEDICINE (2020)

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Article Immunology

NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel

Meng Liu et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Multidisciplinary Sciences

Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart

Haipeng Guo et al.

NATURE COMMUNICATIONS (2020)

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Article Engineering, Biomedical

The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure

Sheng He et al.

BIOMATERIALS (2020)

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Review Medicine, Research & Experimental

The roles of circular RNAs in human development and diseases

Eric Chun Shen Lee et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

The Hippo and Wnt signalling pathways: crosstalk during neoplastic progression in gastrointestinal tissue

Nianshuang Li et al.

FEBS JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription

Xince Huang et al.

MOLECULAR CANCER (2019)

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Article Multidisciplinary Sciences

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Venkata Naga Srikanth Garikipati et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF

Yingzhun Chen et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Review Cell Biology

Circular RNA in cardiovascular disease

M-Ashraf Altesha et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Ca2+-Calcineurin-NFAT pathway mediates the effect of thymol on oxidative metabolism and fiber-type switch in skeletal muscle

Pei Luo et al.

FOOD & FUNCTION (2019)

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Article Cardiac & Cardiovascular Systems

Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure

Kevin J. Morine et al.

CIRCULATION (2018)

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Article Biochemistry & Molecular Biology

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

Xiaoguang Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Cardiac & Cardiovascular Systems

DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways

Chun-gang Zhai et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

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Article Plant Sciences

Luhong formula inhibits myocardial fibrosis in a paracrine manner by activating the gp130/JAK2/STAT3 pathway in cardiomyocytes

Huiyan Qu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

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Article Medicine, Research & Experimental

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

Yan Zeng et al.

THERANOSTICS (2017)

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Article Multidisciplinary Sciences

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Kuei-Chun Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Biochemistry & Molecular Biology

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

Yuka Morikawa et al.

SCIENCE SIGNALING (2015)

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Article Biochemistry & Molecular Biology

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

Yuka Morikawa et al.

SCIENCE SIGNALING (2015)

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Article Cardiac & Cardiovascular Systems

Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

Zhiqiang Lin et al.

CIRCULATION RESEARCH (2014)

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Article Cell Biology

The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes

D. O. Wennmann et al.

CELL DEATH & DISEASE (2014)

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Review Biophysics

The myofibroblast: Paradigm for a mechanically active cell

Boris Hinz

JOURNAL OF BIOMECHANICS (2010)

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Article Biochemistry & Molecular Biology

NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure

Meriem Bourajjaj et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Cardiac & Cardiovascular Systems

Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats

Arne Yndestad et al.

EUROPEAN JOURNAL OF HEART FAILURE (2006)

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Review Cardiac & Cardiovascular Systems

Ventricular remodeling after infarction and the extracellular collagen matrix - When is enough enough?

BI Jugdutt

CIRCULATION (2003)

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Review Biochemistry & Molecular Biology

Partners in transcription:: NFAT and AP-1

F Macián et al.

ONCOGENE (2001)

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The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1

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