Nanomaterials in microchip electrophoresis-A review

Microchip electrophoresis is the most promising method for developing an integrated lab-on-a-chip device for preconcentration, separation, and detection of various compounds in a single device. The unique properties of nanomaterials and the possibility to manufacture nanomaterials with tailored properties have opened up vast possibilities for their use in electrophoresis. This comprehensive review provides an overview of recent applications of nanomaterials in microchip electrophoresis published in the literature since 2010, with noting some earlier published fundamental papers. The latest developments in using new nanomaterials as stationary and pseudostationary phases for optimizing separation conditions are presented and the applications of new microchip electrophoresis methods are discussed. Additionally, the use of nanomaterials for preconcentration (sample preparation) of analytes prior to the microchip electrophoresis analysis is also summarized. The purpose of this review is to highlight the increased capabilities of microchip electrophoresis and nanomaterial synergy as a progressive area of analytical separation methods. & COPY; 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

Microchip electrophoresis is the most promising method for integrated lab-on-a-chip devices, and the use of nanomaterials in electrophoresis has opened up vast possibilities. This comprehensive review provides an overview of recent applications of nanomaterials in microchip electrophoresis, including their use as stationary and pseudostationary phases, as well as for analyte preconcentration. The review aims to highlight the increased capabilities of microchip electrophoresis and nanomaterial synergy in analytical separation methods.