Combining chemometrics and paper-based analytical devices for sensing: An overview

Paper-based Analytical Devices (PADs) have changed the paradigm of chemical sensor development in point-of-need detection and diagnostics. Instead of the univariate method, the potentiality to extract a large quantity of information based on chemometrics techniques can enhance the well-known potential of the PADs to detect multiple analytes or discriminate and classify samples. The proposed article reviews recent progress on PADs using different analytical techniques to extract information (Colorimetric, Electrochemical, SERS, and Fluorescence) and their combination with chemometrics, demonstrating their combined advantages to generate powerful analytical platforms. The pioneering studies that significantly impacted the field of paper-based sensing are critically reviewed, along with future challenges to overcome.& COPY; 2023 Elsevier B.V. All rights reserved.

Automated summary

Paper-based Analytical Devices (PADs) have revolutionized chemical sensor development in point-of-need detection and diagnostics by utilizing chemometrics techniques to extract a large quantity of information. This article reviews recent progress on PADs using different analytical techniques (Colorimetric, Electrochemical, SERS, and Fluorescence) and their combination with chemometrics, highlighting their combined advantages in generating powerful analytical platforms. The pioneering studies in the field of paper-based sensing are critically reviewed, along with future challenges to overcome.