期刊
MOVEMENT DISORDERS
卷 31, 期 7, 页码 1027-1032出版社
WILEY
DOI: 10.1002/mds.26597
关键词
Parkinson's disease; fatigue; acupuncture; randomized; controlled trial
资金
- Michael J. Fox Foundation for Parkinson's Research [5264]
- BA/BS-MD Program at the University of Colorado Denver
BackgroundFatigue is a common and debilitating nonmotor symptom of PD. Because preliminary evidence suggests that acupuncture improves fatigue in other conditions, we sought to test its efficacy in PD. MethodsNinety-four PD patients with moderate-to-high fatigue were randomized to receive 6 weeks of biweekly real or sham acupuncture. The primary outcome was change on the Modified Fatigue Impact Scale at 6 weeks. Secondary outcomes included sleep, mood, quality of life, and maintenance of benefits at 12 weeks. ResultsBoth groups showed significant improvements in fatigue at 6 and 12 weeks, but with no significant between-group differences. Improvements from baseline in mood, sleep, and quality of life were noted without between-group differences. Overall, 63% of patients reported noticeable improvements in their fatigue. No serious adverse events were observed. ConclusionsAcupuncture may improve PD-related fatigue, but real acupuncture offers no greater benefit than sham treatments. PD-related fatigue should be added to the growing list of conditions that acupuncture helps primarily through nonspecific or placebo effects. (c) 2016 International Parkinson and Movement Disorder Society
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