期刊
MOVEMENT DISORDERS
卷 31, 期 9, 页码 1417-1421出版社
WILEY-BLACKWELL
DOI: 10.1002/mds.26678
关键词
Parkinson's disease; orthostatic hypotension; autonomic dysfunction; leptin
资金
- Japan Society for the Promotion of Science (JSPS KAKENHI) [24590691]
- Grants-in-Aid for Scientific Research [24590691, 15K09350] Funding Source: KAKEN
IntroductionLeptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PD patients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PD patients. MethodsWe enrolled 55 patients and 25 age-matched healthy controls in this study. Associations between head-up tilt test measurements and leptin levels were evaluated. ResultsSystolic blood pressure changes during the head-up tilt tests were strongly correlated with leptin levels at baseline and at a 60-degree head-up tilt in PD patients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes. ConclusionThese observations suggest that low leptin levels may be associated with orthostatic hypotension during the head-up tilt test in patients with PD. (c) 2016 International Parkinson and Movement Disorder Society
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