期刊
MOVEMENT DISORDERS
卷 31, 期 11, 页码 1591-1601出版社
WILEY
DOI: 10.1002/mds.26719
关键词
computational model; dopamine; oscillations; pathways; striatum
资金
- German Research Foundation (Deutsche Forschungsgemeinschaft)
The basal ganglia are a complex neuronal system that is impaired in several movement disorders, including Parkinson's disease, Huntington's disease, and dystonia. Empirical studies have provided valuable insights into the brain dysfunctions underlying these disorders. The systems-level perspective, however, of how patients' motor, cognitive, and emotional impairments originate from known brain dysfunctions has been a challenge to empirical investigations. These causal relations have been analyzed via computational modeling, a method that describes the simulation of interacting brain processes in a computer system. In this article, we review computational insights into the brain dysfunctions underlying Parkinson's disease, Huntington's disease, and dystonia, with particular foci on dysfunctions of the dopamine system, basal ganglia pathways, and neuronal oscillations. (c) 2016 International Parkinson and Movement Disorder Society
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