circ_SPEF2 Regulates the Balance of Treg Cells by Regulating miR-16-5p/BACH2 in Lymphoma and Participates in the Immune Response

Article Immunology

Circ_0003645 serves as miR-335-5p sponge to promote the biological process of diffuse large B-cell lymphoma by upregulating NFIB

Dayi Lin et al.

Summary: This study revealed that circ_0003645 promotes the proliferation and glycolysis of DLBCL cells through the miR-335-5p/NFIB axis, providing a novel insight for DLBCL treatment.

AUTOIMMUNITY (2022)

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Article Oncology

circUSP34 accelerates osteosarcoma malignant progression by sponging miR-16-5p

Jingbing Lou et al.

Summary: Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor with unclear pathological mechanisms. This study found that circUSP34 promotes the proliferation, migration, and invasion of OS by sponging miR-16-5p, suggesting it as a potential therapeutic target and biomarker.

CANCER SCIENCE (2022)

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Article Integrative & Complementary Medicine

hsa-MicroRNA-28-5p Inhibits Diffuse Large B-Cell Lymphoma Cell Proliferation by Downregulating 14-3-3ζ Expression

Shufang Yan et al.

Summary: MicroRNAs (miRNAs) play crucial roles in the biological processes of various cancer types. In this study, it was found that hsa-miR-28-5p was downregulated while YWHAZ was upregulated in diffuse large B-cell lymphoma (DLBCL) tissues. Functional analyses revealed that overexpression of hsa-miR-28-5p inhibited cell proliferation in DLBCL, and YWHAZ was identified as a target gene of hsa-miR-28-5p.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Oncology

Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia

Carmela Ciardullo et al.

Summary: This study investigates the clinical significance of B-cell regulators BACH2 and BCL6 in chronic lymphocytic leukaemia (CLL). The results show that low levels of BACH2 and BCL6 RNA expression are associated with shorter overall survival in CLL patients.

CANCERS (2022)

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Article Obstetrics & Gynecology

New biomarkers in peripheral blood of patients with ovarian cancer: high expression levels of miR-16-5p, miR-17-5p, and miR-638

Mukaddes Avsar Saral et al.

Summary: The study found that miR-16-5p, miR-17-5p, and miR-638 miRNA gene expression levels were significantly higher in ovarian cancer patients compared to healthy controls, potentially serving as noninvasive biomarkers for identifying ovarian cancer. Further research is needed to determine the diagnostic and prognostic value of these miRNAs in benign ovarian diseases and during treatment.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Article Respiratory System

LINC00152 knockdown suppresses tumorigenesis in non-small cell lung cancer via sponging miR-16-5p

Hang Hu et al.

Summary: This study found that LINC00152-silencing suppressed NSCLC tumorigenesis by regulating the miR-16-5p/BCL2L2 axis. This finding suggests that LINC00152 may serve as a potential target for the treatment of non-small cell lung cancer.

JOURNAL OF THORACIC DISEASE (2022)

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Article Oncology

Down-regulation of circPTTG1IP induces hepatocellular carcinoma development via miR-16-5p/RNF125/JAK1 axis

Rui Peng et al.

Summary: In this study, we discovered that circPTTG1IP, a circular RNA, acts as a tumor suppressor in hepatocellular carcinoma (HCC). Low expression of circPTTG1IP is associated with poor prognosis in HCC patients. Mechanistically, circPTTG1IP functions as a competing endogenous RNA (ceRNA) of RNF125 by binding miR-16-5p, thereby increasing the level of E3 ubiquitin ligase RNF125 and promoting the degradation of JAK1 protein. Filgotinib, a JAK1 inhibitor, can restrict HCC progression induced by low circPTTG1IP expression.

CANCER LETTERS (2022)

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Article Biochemistry & Molecular Biology

Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis

Junjie Cen et al.

Summary: CircSDHC expression is correlated with advanced TNM stage and poor survival in RCC patients, and it promotes RCC progression by competitively binding to miR-127-3p, thereby preventing its suppression of CDKN3 and the E2F1 pathway. This suggests that circSDHC could be a potential therapeutic target in RCC treatment.

MOLECULAR CANCER (2021)

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Article Oncology

Exosomal microRNA panels as biomarkers for hematological malignancies

Milad Moloudizargari et al.

Summary: Exosomal miRNAs can serve as non-invasive biomarkers for hematological malignancies, showcasing high stability and specificity.

CURRENT PROBLEMS IN CANCER (2021)

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Article Biochemistry & Molecular Biology

CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis

Chen-xing Zhao et al.

Summary: In this study, a novel circRNA circEAF2 was identified, which was found to be downregulated in EBV + DLBCL and negatively correlated with EBV infection and DLBCL progression. CircEAF2 counteracted EBV + DLBCL progression via the miR-BART19-3p/APC/beta-catenin axis, suggesting circEAF2 as a potential prognostic biomarker. Therapeutic targeting of EBV-encoded miRNA may prove to be a promising strategy in treating EBV-associated lymphoid malignancies.

MOLECULAR CANCER (2021)

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Article Cell Biology

NRF1-regulated CircNSUN2 promotes lymphoma progression through activating Wnt signaling pathway via stabilizing HMGA1

Lifu Wang et al.

Summary: The study found that circNSUN2 is highly expressed in malignant lymphoma tissues and cell lines, and its inhibition can reduce proliferation and invasion of lymphoma.

CELL CYCLE (2021)

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Article Biochemistry & Molecular Biology

CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the progression of diffuse large B-cell lymphoma via acting as a sponge of miR-431-5p

Wei Liu et al.

Summary: The study reveals that circ_OTUD7A is highly expressed in DLBCL and promotes DLBCL progression by regulating the miR-431-5p/FOXP1 axis. Silencing circ_OTUD7A inhibits DLBCL cell proliferation and metastasis, while silencing FOXP1 also hinders DLBCL progression.

GENES & GENOMICS (2021)

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Article Hematology

BACH2 is a putative T-cell lymphoma tumor suppressor that may play a role in product-derived CAR T-cell lymphomas

Jay Daniels et al.

BLOOD (2021)

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Article Biology

CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression

Yan Chen et al.

Summary: The study revealed that CTLA-4 expression in lymphoma tissue positively correlated with CD44+ cells and regulatory T cells, and CTLA-4 can enhance lymphoma stem cell enrichment, proliferation, and invasion through the TGF-beta pathway. Additionally, CTLA-4 promoted the proliferation of T cells induced by lymphoma cells.

OPEN LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Circular RNAs in Blood Malignancies

Olivia Perez de Acha et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Immunology

High Treg Inflammations Promote (Most) Non-Hematologic Cancers While Low Treg Inflammations Promote Lymphoid Cancers

Zeev Elkoshi

JOURNAL OF INFLAMMATION RESEARCH (2020)

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Article Cell Biology

CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway

Guanqun Huang et al.

CELL DEATH & DISEASE (2020)

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Review Biotechnology & Applied Microbiology

Non-Coding RNAs in Diffuse Large B-Cell Lymphoma

Yan Shi et al.

ONCOTARGETS AND THERAPY (2020)

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Article Biochemistry & Molecular Biology

Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells

Chao Ni et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Genetics & Heredity

Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression

Liling Deng et al.

GENE (2019)

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Article Cell Biology

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888

Yanping Hu et al.

AGING-US (2019)

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Article Oncology

Incidence and Mortality Trends and Risk Prediction Nomogram for Extranodal Diffuse Large B-Cell Lymphoma: An Analysis of the Surveillance, Epidemiology, and End Results Database

Xuejiao Yin et al.

FRONTIERS IN ONCOLOGY (2019)

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Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Xianjie Jiang et al.

MOLECULAR CANCER (2019)

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Article Oncology

CircRNAs and cancer: Biomarkers and master regulators

Esther Arnaiz et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Review Cell Biology

The Critical Role of Bach2 in Shaping the Balance between CD4+ T Cell Subsets in Immune-Mediated Diseases

Lingyi Yang et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Cell Biology

Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Zihao Liu et al.

CELL DEATH & DISEASE (2019)

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Review Cell Biology

The emerging roles and functions of circular RNAs and their generation

Chun-Ying Yu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

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Review Oncology

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

Stefan B. Eichmueller et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Review Oncology

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

Stefan B. Eichmueller et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Review Allergy

The Bach Family of Transcription Factors: A Comprehensive Review

Yin Zhou et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Makoto Kuwahara et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

Bin Shang et al.

SCIENTIFIC REPORTS (2015)

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Article Oncology

Several immune escape patterns in non-Hodgkin's lymphomas

Camille Laurent et al.

ONCOIMMUNOLOGY (2015)

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Article Hematology

Prognosis of patients with diffuse large B cell lymphoma not reaching complete response or relapsing after frontline chemotherapy or immunochemotherapy

Jordina Rovira et al.

ANNALS OF HEMATOLOGY (2015)

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Review Hematology

Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity

Laurie H. Sehn et al.

BLOOD (2015)

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Article Biochemistry & Molecular Biology

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Shoukat Afshar-Sterle et al.

NATURE MEDICINE (2014)

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Review Oncology

Role of microRNA in the pathogenesis of malignant lymphoma

Hiroyuki Tagawa et al.

CANCER SCIENCE (2013)

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Article Multidisciplinary Sciences

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

Rahul Roychoudhuri et al.

NATURE (2013)

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Review Immunology

The Many Roles of FAS Receptor Signaling in the Immune System

Andreas Strasser et al.

IMMUNITY (2009)

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Article Immunology

Human Circulating CD4+CD25highFoxp3+ Regulatory T Cells Kill Autologous CD8+ but Not CD4+ Responder Cells by Fas-Mediated Apoptosis

Laura Strauss et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Hematology

Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma

Sajjan Mittal et al.

BLOOD (2008)

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Article Immunology

CD4+ CD25+ Foxp3+ regulatory T cells induce cytokine deprivation -mediated apoptosis of effector CD4+ T cells

Pushpa Pandiyan et al.

NATURE IMMUNOLOGY (2007)

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Review Cell Biology

Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression

Karsten Mahnke et al.

CELLULAR IMMUNOLOGY (2007)

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Article Hematology

Activated CD4+CD25+ T cells selectively kill B lymphocytes

Dong-Mei Zhao et al.

BLOOD (2006)

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Review Immunology

Regulatory T cells, tumour immunity and immunotherapy

WP Zou

NATURE REVIEWS IMMUNOLOGY (2006)

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Review Biochemistry & Molecular Biology

MicroRNAs: Genomics, biogenesis, mechanism, and function

DP Bartel

CELL (2004)

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Article Hematology

B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs

T Kamio et al.

BLOOD (2003)

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circ_SPEF2 Regulates the Balance of Treg Cells by Regulating miR-16-5p/BACH2 in Lymphoma and Participates in the Immune Response

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