期刊
TETRAHEDRON LETTERS
卷 131, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2023.154765
关键词
Pyrano-imidazo-pyridine; Domino four component; MCRs and NMSM
A facile method for the synthesis of novel compounds 7 and 8 has been developed, utilizing readily available starting materials and achieving high yields. Notably, the reaction is characterized by its short reaction time, simplicity in workup, and scalability.
A facile one-pot four-component domino protocol has been successfully developed for the combinatorial synthesis of novel N-methyl-3-nitro-4-aryl-4H-pyrano[2 ',3 ':4,5]imidazo[1,2-a]pyridine-2-amine 7 and 2-amino-4aryl-4H-pyrano[2 ',3 ':4,5]imidazo[1,2-a]pyridine-3-carbonitrile 8. The protocol employs readily available starting materials, leading to high yields of the products (83-89%). The transformation involves a domino Knoevenagel-intramolecular Michael reaction sequence, enabling the formation of three new bonds (two C-C, two C-N, and one C-O) and two rings in a single step. Notably, this reaction exhibits several remarkable features, including short reaction time, eliminating the need for extensive workup and column chromatographic purification. Additionally, the reaction demonstrates good scalability, producing satisfactory yields even on a gram-scale.
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