Synthesis of (±)-Protoconstipatic acid methyl ester

Protoconstipatic acid methyl ester was synthesized from the readily available dimethyl itaconate-anthracene adduct as a building block; reacted with the novel protected hydroxy aldehyde via tandem aldol-lactonization, isomerization and pyrolysis, respectively, producing 23% overall yield.

Automated summary

Protoconstipatic acid methyl ester was synthesized from a readily available compound. The reaction involved tandem aldol-lactonization, isomerization, and pyrolysis, resulting in an overall yield of 23%.