A facile synthesis of (E)-5-arylylidene-3-((substituted-ind-2-en-1-one) methyl)-3-aryl piperidine-2,6-diones via domino bis-cyclization using the Baylis-Hillman adducts

A simple and efficient synthesis of (E)-5-arylylidene-3-((substituted-ind-2-en-1-one)methyl)-3-aryl piperidine-2,6-diones from Baylis-Hillman acetates via bis-alkylation of aryl acetonitriles followed by facile domino bis- cyclization involving C-C bond and C-N bond formation reactions are described.

Automated summary

A simple and efficient method for synthesizing (E)-5-arylylidene-3-((substituted-ind-2-en-1-one)methyl)-3-aryl piperidine-2,6-diones from Baylis-Hillman acetates is described. This involves bis-alkylation of aryl acetonitriles followed by a facile domino bis-cyclization reaction involving C-C and C-N bond formations.