期刊
MOVEMENT DISORDERS
卷 32, 期 2, 页码 241-245出版社
WILEY
DOI: 10.1002/mds.26856
关键词
Parkinson's disease; familial aggregation; family history; first-degree relatives; prospective cohort; disease characteristics; genetics
资金
- Norwegian Parkinson Association's Research Foundation
- Western Norway Regional Health Authority [911218]
- Research Council of Norway [177966]
BackgroundFamilial aggregation has been described in PD of both early and late onset, but has not been studied in a true population-based sample. Moreover, little is known about its association with disease progression and endophenotypes. ObjectivesThe objectives of this work were to determine familial aggregation of idiopathic PD in a population-based cohort and study the association with clinical endophenotypes and disease progression. MethodsWe examined family history data from the Norwegian ParkWest study, a well-characterized, population-based cohort of incident PD patients and age-matched healthy controls. Family data were collected at baseline with a simplified questionnaire (192 cases and 193 controls) and after 3 years of longitudinal follow-up using an extended questionnaire (172 cases and 171 controls). ResultsCompared to the controls, the PD patients had an increased relative risk of having a first-degree relative with PD when using the extended questionnaire (relative risk = 1.988; P = 0.036), but not when using the simplified questionnaire (relative risk = 1.453; P = 0.224). There was no significant difference in age of onset or motor subtype (P = 0.801). However, cases with a family history of PD had reduced progression over 7 years as measured by UPDRS II (P = 0.008) and smaller rate of decrease of MMSE (P = 0.046). ConclusionsOur findings confirm familial aggregation in a population-based cohort of idiopathic PD. Moreover, we show that positive family history of PD in patients is associated with a slower progression of PD symptoms and cognitive decline. (c) 2016 International Parkinson and Movement Disorder Society
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