Electrochemical oxidative transamidation of tertiary amines with N-acyl imides to access amide compounds

A novel and efficient electrochemical oxidative transamidation of tertiary amines with N-acyl imides is described. This protocol is environmentally friendly and ease to handle as tertiary amines are used as surrogates for secondary amines. The C-N bond of tertiary amines is cleaved, preparing amide compounds in a facile approach with 29 examples in 11-80% yields.

Automated summary

This article describes a novel and efficient electrochemical oxidative transamidation of tertiary amines with N-acyl imides. The protocol is environmentally friendly and easy to handle, as tertiary amines are used as surrogates for secondary amines. The C-N bond of tertiary amines is cleaved, preparing amide compounds in a facile approach with 29 examples in yields ranging from 11% to 80%.