Progress on the Enantioselective Synthesis of Axially Chiral Cycloalkylidenes

The discovery of new asymmetric synthetic methodologies and the asymmetric synthesis of new chiral compounds have been a major focus of synthetic organic chemists for decades. Axially chiral compounds have gained considerable attention in recent years because of their widespread utility in asymmetric catalysis and synthesis. Methods for the asymmetric synthesis of axially chiral cycloalkylidenes, a subset of axially chiral molecules, are far fewer compared to those developed for the preparation of chiral allenes and chiral biaryl compounds. In this review, different approaches for the synthesis of axially chiral cycloalkylidenes are summarized

Automated summary

The synthesis of chiral compounds has always been a major focus of organic chemists. In recent years, axially chiral compounds have gained considerable attention due to their widespread utility in asymmetric catalysis and synthesis. However, compared to chiral allenes and chiral biaryl compounds, there are fewer methods available for the asymmetric synthesis of axially chiral cycloalkylidenes.