Photoinduced Alkylation of Diazines with N -(Acyloxy)phthalimides in the Presence of Triethylamine

A photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines, and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated by the presence of triethylamine under irradiation with 427-390 nm light; this enables rapid cross-coupling reactions to construct a wide range of alkylated diazines.

Automated summary

A photochemical protocol has been developed for the alkylation of diazines (pyrimidines, pyrazines, and pyridazines) with N-(acyloxy)phthalimides. The process is facilitated by the presence of triethylamine under irradiation with 427-390 nm light, enabling rapid cross-coupling reactions to construct a wide range of alkylated diazines.