A tale of two switches: Redox regulation of adenosine-5'-phosphosulfate kinase in humans and plants

The sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) is a near-universal component of sulfur metabolism. In a report by Zhang et al. in this issue of Structure, X-ray crystal structures of the APS kinase domains from human PAPS synthase reveal dynamic substrate recognition and a regulatory redox switchanalogous to that previously described only in plant APS kinases.

Automated summary

In this study, the X-ray crystal structures of APS kinase domains from human PAPS synthase were determined, showing the dynamic substrate recognition and a regulatory redox switch similar to plant APS kinases.