Electroanatomical mapping after cardiac radioablation for treatment of incessant electrical storm: a case report from the RAVENTA trial

Letter Cardiac & Cardiovascular Systems

Ventricular Conduction Velocity Following Multimodal Ablation Including Stereotactic Body Radiation Therapy for Refractory Ventricular Tachycardia

John Whitaker et al.

JACC-CLINICAL ELECTROPHYSIOLOGY (2023)

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Editorial Material Oncology

Cardiac stereotactic Radiation Therapy induces Reprogramming of the electrical Conduction System

Oliver Blanck et al.

STRAHLENTHERAPIE UND ONKOLOGIE (2022)

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Letter Cardiac & Cardiovascular Systems

Correlation between the radiation dose and myocardial remodeling after stereotactic radiation therapy for ventricular tachycardia: First assessment of the dose-effect relationship in humans

Karim Benali et al.

HEART RHYTHM (2022)

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Article Oncology

Treatment Planning for Cardiac Radioablation: Multicenter Multiplatform Benchmarking for the RAdiosurgery for VENtricular TAchycardia (RAVENTA) Trial

Anne Kluge et al.

Summary: This study aimed to provide a benchmark for treatment planning of cardiac radioablation in multicenter clinical studies and establish an objective ranking system for plan quality. By collecting and analyzing treatment plans developed using different platforms and techniques in different centers, it was found that although most plans deviated slightly from the study guidelines, the overall plan quality was acceptable. VMAT plans had steeper dose gradients in the high-dose region, while plans for robotic arm LINAC had smaller low-dose regions.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Review Cardiac & Cardiovascular Systems

The effect of ionizing radiation through cardiac stereotactic body radiation therapy on myocardial tissue for refractory ventricular arrhythmias: A review

John Whitaker et al.

Summary: Cardiac stereotactic body radiation therapy (cSBRT) is a non-invasive treatment modality that has been effective for ventricular arrhythmias. Despite some success, there is limited understanding of the radiobiology of its anti-arrhythmic effect and unclear mechanisms. Future research is needed to optimize the treatment's efficacy and explore its potential.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation

Myung-Jin Cha et al.

Summary: High-dose cardiac radioablation induced mononuclear cell-related intracellular and extracellular edema, diffuse vacuolization, and widened intercalated discs in rat hearts within 1 month. ECG showed intracardiac conduction delay and significant ST-segment changes. These findings suggest that early antiarrhythmic effects following cardiac radioablation are due to conduction disturbances and membrane potential alterations, rather than necrosis.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Multidisciplinary Sciences

Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

David M. Zhang et al.

Summary: Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients by reprogramming cardiac conduction without transmural fibrosis, potentially offering a new treatment strategy for arrhythmia management.

NATURE COMMUNICATIONS (2021)

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Article Cardiac & Cardiovascular Systems

Recommendations regarding cardiac stereotactic body radiotherapy for treatment refractory ventricular tachycardia

David Krug et al.

Summary: Experts established a consensus on the use of cardiac stereotactic body radiotherapy (CSBRT) for refractory ventricular tachycardia (VT). The procedure is considered experimental and should be conducted in specialized centers with expertise in managing ventricular arrhythmias and stereotactic body radiotherapy for moving targets. Patient selection is crucial and interdisciplinary collaboration is needed for optimal results.

HEART RHYTHM (2021)

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Article Oncology

Interdisciplinary Clinical Target Volume Generation for Cardiac Radioablation: Multicenter Benchmarking for the RAdiosurgery for VENtricular TAchycardia (RAVENTA) Trial

Judit Boda-Heggemann et al.

Summary: The study aimed to evaluate the complex transfer process and consistency of structure definition in cardiac radioablation, providing a new treatment option for therapy-refractory ventricular tachycardia.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

Standardizing the Cardiac Radioablation Targeting Workflow: Enabling Semi-Automated Angulation and Segmentation of the Heart According to the American Heart Association Segmented Model

Martijn H. van der Ree et al.

Summary: This study developed a semi-automatic angulation and segmentation tool for cardiac radioablation based on the American Heart Association 17-segment model. The tool showed good reproducibility in evaluating heart segmentation, promoting communication between radiation oncology and cardiology, and enabling cardiology-oriented targeting and toxicity evaluations.

ADVANCES IN RADIATION ONCOLOGY (2021)

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Article Oncology