Social cognition in hyperkinetic movement disorders: a systematic review

Numerous lines of research indicate that our social brain involves a network of cortical and subcortical brain regions that are responsible for sensing and controlling body movements. However, it remains unclear whether movement disorders have a systematic impact on social cognition. To address this question, we conducted a systematic review examining the influence of hyperkinetic movement disorders (including Huntington disease, Tourette syndrome, dystonia, and essential tremor) on social cognition. Following the PRISMA guidelines and registering the protocol in the PROSPERO database (CRD42022327459), we analyzed 50 published studies focusing on theory of mind (ToM), social perception, and empathy. The results from these studies provide evidence of impairments in ToM and social perception in all hyperkinetic movement disorders, particularly during the recognition of negative emotions. Additionally, individuals with Huntington's Disease and Tourette syndrome exhibit empathy disorders. These findings support the functional role of subcortical structures (such as the basal ganglia and cerebellum), which are primarily responsible for movement disorders, in deficits related to social cognition.

Automated summary

A systematic review analyzed 50 published studies and found that hyperkinetic movement disorders, including Huntington disease, Tourette syndrome, dystonia, and essential tremor, have a negative impact on social cognition, particularly in theory of mind, social perception, and empathy. Impairments were observed in the recognition of negative emotions, and empathy disorders were found in individuals with Huntington's Disease and Tourette syndrome. These findings suggest the involvement of subcortical structures responsible for movement disorders in deficits related to social cognition.