☆ 4.8 Review

Stimuli-Actuated Turn-On Theranostic Nanoplatforms for Imaging-Guided Antibacterial Treatment

SMALL (2023)

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ACTA BIOMATERIALIA (2022)

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ACTA BIOMATERIALIA (2022)

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Responsive nanoplatform for persistent luminescence turn-on imaging and on-demand synergistic therapy of bacterial infection

Bei-Bei Wang et al.

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Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections

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Summary: Traditional antibiotic treatment is not very effective against bacteria in biofilms due to their unique metabolic conditions. This study explores the use of photodynamic therapy to eliminate methicillin-resistant Staphylococcus aureus biofilms and enhance the hypoxic microenvironment, which induces anaerobic metabolism and activates the antibacterial activity of metronidazole. Additionally, the activated chemotherapy can promote the repair of biofilm-infected wounds by polarizing macrophages to a specific phenotype.

NATURE COMMUNICATIONS (2022)

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Yun Zeng et al.

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A MOF-armored zinc-peroxide nanotheranostic platform for eradicating drug resistant bacteria via image-guided and in situ activated photodynamic therapy

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Spectral computed tomography with inorganic nanomaterials: State-of-the-art

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ADVANCED DRUG DELIVERY REVIEWS (2022)

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Precise Monitoring and Assessing Treatment Response of Sepsis-Induced Acute Lung Hypoxia with a Nitroreductase-Activated Golgi-Targetable Fluorescent Probe

Zhixin Tang et al.

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ANALYTICAL CHEMISTRY (2022)

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Macrophage-Membrane-Camouflaged Nonviral Gene Vectors for the Treatment of Multidrug-Resistant Bacterial Sepsis

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Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Yanling Hu et al.

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NANO TODAY (2022)

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Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

Juan-Juan Li et al.

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Current status and future prospects of nanoscale metal-organic frameworks in bioimaging

Mahsa Nazari et al.

Summary: Early-stage diagnosis, in situ monitoring of lesion regions, and transportation of bioactive molecules are crucial for the successful treatment of serious diseases. Nanoscale metal-organic frameworks (NMOFs) have been extensively studied in the biomedical field as drug carriers, diagnostic and therapeutic agents, and biosensors, due to their high surface area and porosity.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

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An NIR-II light responsive antibacterial gelation for repetitious photothermal/thermodynamic synergistic therapy

Qinzhe Li et al.

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CHEMICAL ENGINEERING JOURNAL (2021)

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Review Microbiology

Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

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NATURE REVIEWS MICROBIOLOGY (2021)

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Precise magnetic resonance imaging-guided sonodynamic therapy for drug-resistant bacterial deep infection

Dong Wang et al.

Summary: The study introduces a novel approach for treating drug-resistant deep bacterial infections using a polymer-peptide-porphyrin conjugate (PPPC) to achieve accurate and deep sonodynamic therapy (SDT). PPPC can be monitored in real-time at the infectious site and effectively eliminates drug-resistant bacteria, showing promising applications in the field.

BIOMATERIALS (2021)

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Review Polymer Science

Targeted polymer-based antibiotic delivery system: A promising option for treating bacterial infections via macromolecular approaches

Tengjiao Wang et al.

Summary: Antibiotic therapy has been crucial in treating bacterial infections, but systemic administration comes with limitations. Polymer-based antibiotic delivery systems (PADS) offer a solution to these limitations by protecting antibiotics and targeting infection sites, resulting in enhanced therapeutic effects.

PROGRESS IN POLYMER SCIENCE (2021)

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Review Chemistry, Multidisciplinary

All-in-One Nanomedicine: Multifunctional Single-Component Nanoparticles for Cancer Theranostics

Yu Cai et al.

Summary: The development of theranostic nanoplatforms integrating imaging and therapy is crucial for cancer precision medicine. Single-component nanoparticles offer advantages of facile preparation, defined structure, and reduced risks to biological systems.

SMALL (2021)

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Article Microbiology

Virulence and Antimicrobial Resistance in Canine Staphylococcus spp. Isolates

Fabrizio Bertelloni et al.

Summary: Dogs can harbor different species of Staphylococcus and can develop various clinical forms caused by these bacteria. Most of the clinical Staphylococcus isolates cultured from sick dogs were Staphylococcus pseudointermedius, with common characteristics including gelatinase, biofilm, and slime production, as well as high levels of multi-drug resistance.

MICROORGANISMS (2021)

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Review Chemistry, Medicinal

Recent Innovations in Bacterial Infection Detection and Treatment

Carly Deusenbery et al.

Summary: Bacterial infections pose a significant threat to human health, aggravated by the rise of antibiotic resistance. Recent advances in detection methods focus on enhancing sensitivity, specificity, and ease of operation, while developments in antibacterial treatment center around targeted delivery and responsive antibiotic administration.

ACS INFECTIOUS DISEASES (2021)

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Article Nanoscience & Nanotechnology

Near-Infrared Photothermal/Photodynamic-in-One Agents Integrated with a Guanidinium-Based Covalent Organic Framework for Intelligent Targeted Imaging-Guided Precision Chemo/PTT/PDT Sterilization

Yu-Shi Liu et al.

Summary: The study presents a smart nanoplatform with synergistic chemo-phototherapy function for targeted imaging and efficient sterilization of bacteria, with minimal side effects on normal tissues.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy

Nan Yang et al.

Summary: A novel theranostic platform based on Cu2O nanoparticles was successfully constructed, which can precisely identify and eliminate bacteria in the infection microenvironment, showing a good antibacterial effect against drug-resistant bacteria.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy

Changyu Cao et al.

Summary: The platelet-inspired degradable antibacterial hydrogel Gel/PP-TA-Ag shows promising hemostatic and antibacterial effects, with potential application in infected wound healing.

NANO TODAY (2021)

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Review Chemistry, Multidisciplinary

NIR-II Organic Nanotheranostics for Precision Oncotherapy

Hanming Dai et al.

Summary: Precision oncotherapy can effectively remove tumors without harming normal tissues.NIR-II organic nanotheranostics show good biocompatibility and safety, holding great potential for clinical tumor treatment.

SMALL (2021)

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Article Materials Science, Biomaterials

The fluorescence imaging and precise suppression of bacterial infections in chronic wounds by porphyrin-based metal-organic framework nanorods

Lihua Zhang et al.

Summary: The study introduces a smart nanosystem for visual infection warning and precise sterilization in chronic wounds. Experimental results demonstrate the system's significant efficacy in accurately detecting infection status and performing sterilization.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

Fluorescence resonance energy transfer enhanced photothermal and photodynamic antibacterial therapy post a single injection

Lei Xue et al.

Summary: This study successfully prepared near-infrared light-triggered theranostic nanoparticles that could targeted assembly and effectively destroy multidrug-resistant bacteria through synergistic photothermal and photodynamic therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Review Chemistry, Multidisciplinary

Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Jingjing Huo et al.

Summary: Given the challenges of bacterial resistance and biofilm protection, photothermal therapy (PTT)-derived multimodal synergistic treatments have emerged as a promising approach to combat bacterial infections. By combining PTT with chemotherapy, photo-dynamic/catalytic therapy, immunotherapy, and sonodynamic therapy, enhanced bactericidal activity can be achieved while minimizing potential side effects.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Materials Science, Biomaterials

Hyaluronidase-responsive phototheranostic nanoagents for fluorescence imaging and photothermal/photodynamic therapy of methicillin-resistant Staphylococcus aureus infections

Lihui Yuwen et al.

Summary: Novel phototheranostic nanoagents with hyaluronidase-responsive fluorescence imaging and photothermal/photodynamic therapy functions have been developed for effective detection and treatment of bacterial infections.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

A photo-triggered antifungal nanoplatform with efflux pump and heat shock protein reversal activity for enhanced chemo-photothermal synergistic therapy

Dongliang Yang et al.

Summary: The newly developed photo-triggered multifunctional nanoplatform can effectively eliminate drug-resistant fungi by releasing a quorum sensing molecule and an antifungal drug, and destroying the integrity of fungal cell membrane, inhibiting the expression of drug efflux pumps and heat shock proteins, and effectively blocking the hyphal and biofilm formation of fungi.

BIOMATERIALS SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Activatable Phototheranostic Materials for Imaging-Guided Cancer Therapy

Penghui Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Biochemical Research Methods

Activatable Fluorescence Probes for Turn-On and Ratiometric Biosensing and Bioimaging: From NIR-I to NIR-II

Chuan Chen et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Engineering, Environmental

Halloysite nanotube-based H2O2-responsive drug delivery system with a turn on effect on fluorescence for real-time monitoring

Cong Cheng et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Multidisciplinary Sciences

Strategies for engineering advanced nanomedicines for gas therapy of cancer

Yingshuai Wang et al.

NATIONAL SCIENCE REVIEW (2020)

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Review Acoustics

THREE DECADES OF ULTRASOUND CONTRAST AGENTS: A REVIEW OF THE PAST, PRESENT AND FUTURE IMPROVEMENTS

Peter Frinking et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Size-Dependent Modulation of Polydopamine Nanospheres on Smart Nanoprobes for Detection of Pathogenic Bacteria at Single-Cell Level and Imaging-Guided Photothermal Bactericidal Activity

Yingwang Ye et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods

Zihan Mei et al.

BIOMATERIALS (2020)

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Article Chemistry, Medicinal

Hypoxia-activated nanomedicines for effective cancer therapy

Mengjiao Zhou et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

pH Reversibly Switchable Nanocapsule for Bacteria-Targeting Near-Infrared Fluorescence Imaging-Guided Precision Photodynamic Sterilization

Xu Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

HClO-Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image-Guided Bacterial Ablation in Phagocytes

Min Wu et al.

ADVANCED MATERIALS (2020)

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Review Pharmacology & Pharmacy

Hydrogen sulfide: An endogenous regulator of the immune system

Nahzli Dilek et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Materials Science, Biomaterials

Recent advances in pH-responsive nanomaterials for anti-infective therapy

Xinyi Lv et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Multidisciplinary

pH/glutathione-responsive release of SO2 induced superoxide radical accumulation for gas therapy of cancer

Rui Gu et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Materials Science, Biomaterials

An acidity-responsive polyoxometalate with inflammatory retention for NIR-II photothermal-enhanced chemodynamic antibacterial therapy

Yunhao Shi et al.

BIOMATERIALS SCIENCE (2020)

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Article Materials Science, Biomaterials

Enzyme-responsive turn-on nanoprobes forin situfluorescence imaging and localized photothermal treatment of multidrug-resistant bacterial infections

Xuancheng Du et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Engineering, Environmental

A bacterial infection-microenvironment activated nanoplatform based on spiropyran-conjugated glycoclusters for imaging and eliminating of the biofilm

Zhuang Ma et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Materials Science, Biomaterials

Fibrous testing papers for fluorescence trace sensing and photodynamic destruction of antibiotic-resistant bacteria

Long Zhao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Pharmacology & Pharmacy

Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool

Jianping Qi et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Engineering, Biomedical

Rejuvenated Photodynamic Therapy for Bacterial Infections

Qingyan Jia et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Engineering, Biomedical

High-resolution bimodal imaging and potent antibiotic/photodynamic synergistic therapy for osteomyelitis with a bacterial inflammation-specific versatile agent

Xiaolin Lu et al.

ACTA BIOMATERIALIA (2019)

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Review Engineering, Biomedical

Theranostic designs of biomaterials for precision medicine in cancer therapy

Hyosuk Kim et al.

BIOMATERIALS (2019)

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Review Chemistry, Multidisciplinary

Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging

Zijian Zhou et al.

ADVANCED MATERIALS (2019)

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Review Engineering, Biomedical

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Ting Wei et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Optical nano-agents in the second near-infrared window for biomedical applications

Yu Cai et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

One-pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors

Dongliang Yang et al.

NEW JOURNAL OF CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

Dongliang Yang et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Nanoscience & Nanotechnology

Black Phosphorus Nanosheets Immobilizing Ce6 for Imaging-Guided Photothermal/Photodynamic Cancer Therapy

Xiaoyan Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

A Gold/Silver Hybrid Nanoparticle for Treatment and Photoacoustic Imaging of Bacterial Infection

Taeho Kim et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Metal-Organic-Framework-Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy

Duo Mao et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Physical

ONOO- and ClO- Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation

Wenbo Wu et al.

CHEMISTRY OF MATERIALS (2018)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide in Physiology and Pathogenesis of Bacteria and Viruses

Virender Kumar Pal et al.

IUBMB LIFE (2018)

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Review Materials Science, Biomaterials

Multifunctional bacterial imaging and therapy systems

Shuai Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Immunology

Pharmacokinetic and Pharmacodynamic Considerations for the Use of Monoclonal Antibodies in the Treatment of Bacterial Infections

Shun Xin Wang-Lin et al.

ANTIBODIES (2018)

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Article Chemistry, Multidisciplinary

Dual-emissive nanoarchitecture of lanthanide-complex- modified silica particles for in vivo ratiometric time-gated luminescence imaging of hypochlorous acid

Hua Ma et al.

CHEMICAL SCIENCE (2017)

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Article Engineering, Biomedical

Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring

Kai Liang et al.

NATURE BIOMEDICAL ENGINEERING (2017)

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Review Pharmacology & Pharmacy

Aggregation-induced emission probes for cancer theranostics

Meng Gao et al.

DRUG DISCOVERY TODAY (2017)

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Article Engineering, Biomedical

Combined photodynamic and antibiotic therapy for skin disorder via lipase-sensitive liposomes with enhanced antimicrobial performance

Songhee Jeong et al.

BIOMATERIALS (2017)

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Article Chemistry, Multidisciplinary

Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy

Xingshu Li et al.

ADVANCED MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Activatable Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation

Zhegang Song et al.

ADVANCED MATERIALS (2016)

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Review Infectious Diseases

Systematic review of the role of angiopoietin-1 and angiopoietin-2 in Plasmodium species infections: biomarkers or therapeutic targets?

Gerdie M. de Jong et al.

MALARIA JOURNAL (2016)

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Article Chemistry, Multidisciplinary

Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection

Haiwei Ji et al.

SMALL (2016)

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Article Engineering, Biomedical

Lipase-Sensitive Transfersomes Based on Photosensitizer/Polymerizable Lipid Conjugate for Selective Antimicrobial Photodynamic Therapy of Acne

Hyung Park et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Article Biochemistry & Molecular Biology

Nitric Oxide Regulation of Bacterial Biofilms

Dhruv P. Arora et al.

BIOCHEMISTRY (2015)

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Review Chemistry, Multidisciplinary

Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects

Sijumon Kunjachan et al.

CHEMICAL REVIEWS (2015)

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Review Microbiology

Targeted imaging of bacterial infections: advances, hurdles and hopes

Marleen van Oosten et al.

FEMS MICROBIOLOGY REVIEWS (2015)

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Review Engineering, Biomedical

Advances in Computed Tomography Imaging Technology

Daniel Thomas Ginat et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16 (2014)

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Review Chemistry, Multidisciplinary

Theranostic nanoparticles for future personalized medicine

Ju Hee Ryu et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Chemistry, Multidisciplinary

FRET-Based Small-Molecule Fluorescent Probes: Rational Design and Bioimaging Applications

Lin Yuan et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Article Chemistry, Multidisciplinary

Multicolor Fluorescent Semiconducting Polymer Dots with Narrow Emissions and High Brightness

Yu Rong et al.

ACS NANO (2013)

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Review Biochemistry & Molecular Biology

The fairytale of the GSSG/GSH redox potential

Leopold Flohe

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

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Review Chemistry, Multidisciplinary

Molecular tracers for the PET and SPECT imaging of disease

Sally L. Pimlott et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Review Radiology, Nuclear Medicine & Medical Imaging

Positron Emission Tomography as a Diagnostic Tool in Infection: Present Role and Future Possibilities

Sandip Basu et al.

SEMINARS IN NUCLEAR MEDICINE (2009)

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Article Pharmacology & Pharmacy

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid

Jingbo Pi et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)

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Article Chemistry, Analytical

Aptamer-based biosensors

Shiping Song et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2008)

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Review Medicine, General & Internal

Current concepts - Computed tomography - An increasing source of radiation exposure

David J. Brenner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Review Critical Care Medicine

Biomarkers to improve diagnostic and prognostic accuracy in systemic infections

Philipp Schuetz et al.

CURRENT OPINION IN CRITICAL CARE (2007)

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Review Microbiology

Hyaluronidases of Gram-positive bacteria

WL Hynes et al.

FEMS MICROBIOLOGY LETTERS (2000)

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