4.8 Review

Novel Vectors and Administrations for mRNA Delivery

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin-Induced Murine Model

Rui Zhang et al.

Summary: This study reports an inhalable ribosomal protein-based mRNA nanoformulation for the treatment of IPF, which can clear the intrapulmonary ECM and re-epithelialize the disrupted alveolar epithelium to reverse fibrotic foci. The nanoformulation is delivered to fibrotic foci by inhalation and promotes the clearance of collagen and the re-epithelialization of alveoli, leading to improved lung function.

ADVANCED MATERIALS (2022)

Article Chemistry, Physical

Opportunities and Challenges for mRNA Delivery Nanoplatforms

Yuyan Zhang et al.

Summary: With the outbreak of SARS-CoV-2, mRNA vaccines have played a crucial role in COVID-19 vaccine development and have made significant advances in the field of mRNA therapeutic techniques. However, there are still challenges in terms of stability and cellular delivery. Therefore, exploring efficient and safe delivery technologies is essential for improving mRNA therapeutic techniques.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2022)

Review Pharmacology & Pharmacy

Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery

Hidetomo Yokoo et al.

Summary: This article highlights the distinctive features of CPP-based mRNA delivery systems, including improved mRNA bioavailability, selective targeting of dendritic cells, efficient antigen presentation, and effective mRNA delivery to the lungs by dry powder inhalation.

PHARMACEUTICS (2022)

Review Pharmacology & Pharmacy

Delivery Strategies for mRNA Vaccines

Sivakumar Ramachandran et al.

Summary: This article summarizes the various delivery strategies explored for mRNA vaccines, including different carriers and formulation technologies, as well as the successful cases of COVID-19 vaccines. However, there is still a need to improve the storage stability of these vaccines for transportation to developing countries at low temperatures.

PHARMACEUTICAL MEDICINE (2022)

Review Biochemical Research Methods

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

Min Ji Byun et al.

Summary: RNA therapeutics, such as messenger RNA (mRNA) and small interfering RNA (siRNA), regulate protein production by mediating genetic transcription, but their clinical application is hindered by the lack of an effective delivery system. Nanoparticle-based platforms play a crucial role in enhancing RNA delivery efficiency and safety, with different types of nanoparticles being utilized to augment therapeutic effects through targeted delivery.

BIOCHIP JOURNAL (2022)

Review Biochemistry & Molecular Biology

Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency

Sun Chang Kim et al.

Summary: Modifying mRNA structural elements, such as the 5' cap, 5'-and 3'-untranslated regions (UTRs), the coding region, and polyadenylation tail, helps reduce excessive mRNA immunogenicity and improve intracellular stability and translational efficiency. Further research on mRNA structural elements and their optimization is needed to advance the engineering of mRNA vaccines.

MOLECULAR & CELLULAR TOXICOLOGY (2022)

Article Pharmacology & Pharmacy

The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells

Yelee Kim et al.

Summary: In vitro transcribed mRNA has potential in cancer gene therapy and cancer vaccines. Cell-penetrating peptides (CPPs) show promise as gene delivery tools. This study optimized CPP/mRNA complexes and demonstrated their protective effect against RNase, as well as high cellular uptake and protein expression.

PHARMACEUTICS (2022)

Review Pharmacology & Pharmacy

Cell-Penetrating Peptides as Passive Permeation Enhancers for Transdermal Drug Delivery

Lipika Chablani et al.

Summary: This review highlights the advances in the use of cell-penetrating peptides in preclinical and clinical research, focusing on their role as permeation enhancers for transdermal and topical drug delivery. The review also includes a summary table of preclinical studies utilizing various peptides with different active ingredients and drug delivery systems. Lastly, the challenges associated with translating preclinical work to clinical applications are discussed.

AAPS PHARMSCITECH (2022)

Review Biochemistry & Molecular Biology

mRNA-based therapeutics: powerful and versatile tools to combat diseases

Shugang Qin et al.

Summary: The therapeutic use of mRNA has shown great potential in combating incurable diseases. Recent advances in biotechnology and molecular medicine have allowed for the production of functional proteins/peptides in the human body through mRNA vaccines or therapeutic agents. mRNA vaccines offer the quickest response to large-scale infectious disease outbreaks, such as the current COVID-19 pandemic. Scientists have been working on improving the stability, immunogenicity, translation efficiency, and delivery system of mRNA to achieve efficient and safe delivery. This review comprehensively describes mRNA-based therapeutics, their principles, manufacturing, application, effects, and limitations.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Materials Science, Multidisciplinary

Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections

Alex Abramson et al.

Summary: Nucleic acids have opened up new possibilities for therapeutic drugs and vaccines. Oral delivery offers a preferred dosing method and enables local transfection of cells in the gastrointestinal tract. Researchers have developed mRNA nanoparticles and ingestible capsules to achieve transfection in the stomach, demonstrating efficacy in rodents and pigs.

MATTER (2022)

Review Chemistry, Multidisciplinary

Recent Advances in the Noninvasive Delivery of mRNA

Ming Qin et al.

Summary: Research on mRNA-based therapies has flourished in the past two decades due to the advantages of mRNA. Various noninvasive delivery strategies have been developed to overcome intracellular barriers, with nasal and pulmonary delivery being the most studied areas. The advancement in noninvasive mRNA delivery is expected to accelerate the translation from experimental research to clinical applications.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Review Biochemistry & Molecular Biology

mRNA vaccine for cancer immunotherapy

Lei Miao et al.

Summary: mRNA vaccines have emerged as a promising platform for cancer immunotherapy, showcasing high potency, safe administration, rapid development potentials, and cost-effective manufacturing. However, challenges such as stability, innate immunogenicity, and inefficient in vivo delivery restrict their applications. In addressing these challenges, structural modifications and formulation methods are being researched to enhance the anti-tumor immune response.

MOLECULAR CANCER (2021)

Article Chemistry, Multidisciplinary

In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy

Yue Yin et al.

Summary: The research team developed a transformable hydrogel that can generate nanovaccines for up to 30 days after injection, showing promising potential for effective cancer immunotherapy.

NANO LETTERS (2021)

Review Biotechnology & Applied Microbiology

Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

Saghi Nooraei et al.

Summary: Virus-like particles (VLPs) are virus-derived structures without genetic material, able to self-assemble and mimic viruses, utilized in candidate vaccines and successful applications in targeted drug delivery and gene therapy. Modifying the surface of VLPs for increased specificity and longevity in specific cells or tissues may enhance their future use.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Pharmacology & Pharmacy

Hepatocellular-Targeted mRNA Delivery Using Functionalized Selenium Nanoparticles In Vitro

Dhireshan Singh et al.

Summary: Selenium nanoparticles were formulated for efficient binding and targeted delivery of FLuc-mRNA to HepG2 cells. Functionalized with chitosan, polyethylene glycol, and lactobionic acid, these nanoparticles exhibited targeted gene expression in HepG2 cells with high efficiency in vitro, showing potential as efficient carriers for nucleic acids.

PHARMACEUTICS (2021)

Review Chemistry, Multidisciplinary

Microneedles for gene and drug delivery in skin cancer therapy

Defu Zhi et al.

Summary: Microneedles are an effective delivery method for skin cancer treatment, providing advantages such as bypassing the stratum corneum barrier, delivering drugs and genes in a simple, safe, and painless manner, and improving therapeutic effects. The combination of microneedles with other treatment strategies like photothermal therapy shows promise in enhancing the overall treatment outcomes for skin cancer.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

A Novel Graphene Quantum Dot-Based mRNA Delivery Platform

Ya Liu et al.

Summary: The study explores the use of graphene quantum dots functionalized with polyethyleneimine as a novel mRNA delivery system that can deliver intact and functional mRNA to hepatocarcinoma cells without toxicity. While cellular toxicity remains a concern, the functionalized GQDs show promise as a potentially interesting, easy to manufacture, stable, and effective delivery system.

CHEMISTRYOPEN (2021)

Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

Article Biochemical Research Methods

Highly Photoluminescent Nitrogen- and Zinc-Doped Carbon Dots for Efficient Delivery of CRISPR/Cas9 and mRNA

Akbar Hasanzadeh et al.

Summary: The study developed fluorescent nitrogen- and zinc-doped carbon dots that exhibited high efficiency and safety in the delivery of CRISPR/Cas9 systems, making them a promising platform for the effective and safe transfer of CRISPR plasmids and mRNA into cells.

BIOCONJUGATE CHEMISTRY (2021)

Article Pharmacology & Pharmacy

Sustained release of PKR inhibitor C16 from mesoporous silica nanoparticles significantly enhances mRNA translation and anti-tumor vaccination

Wei Zhang et al.

Summary: A novel mesoporous silica nanoparticles-mRNA subcutaneous delivery system was developed with a potent immune evasion and translation enhancement effect by utilizing C16 inhibitor. In vivo experiments on a tumor model showed significant tumor inhibition using this delivery system, indicating a great translational potential in mRNA therapeutics.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Article Multidisciplinary Sciences

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

Michael Segel et al.

Summary: Eukaryotic genomes contain domesticated genes from integrating viruses and mobile genetic elements, including mammalian Gag homologs and PEG10, which can be used for RNA delivery. The development of selective endogenous encapsidation for cellular delivery (SEND) using PEG10 demonstrates its potential as an efficient therapeutic delivery modality.

SCIENCE (2021)

Article Chemistry, Multidisciplinary

mRNA Delivery by a pH-Responsive DNA Nano-Hydrogel

Xin Fu et al.

Summary: The DNA nano-hydrogel system for mRNA delivery developed in this study shows high efficiency and biocompatibility, with smart intracellular release and compact structure design contributing to enhanced protein expression efficiency.
Article Medicine, Research & Experimental

Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders

Androulla N. Miliotou et al.

Summary: The study developed an innovative method combining IVT-mRNAs with protein transduction domain (PTD) technology as an efficient delivery platform, which was successfully applied and evaluated in two protein-disease models. The novel delivery platform could potentially be clinically applicable as a protein therapy for metabolic/genetic disorders.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Letter Medicine, General & Internal

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Danuta M. Skowronski et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Pharmacology & Pharmacy

Microneedle for transdermal drug delivery: current trends and fabrication

Jae Hwan Jung et al.

Summary: Transdermal drug delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. Microneedles are a painless, less invasive, and easy to self-administer transdermal drug delivery system with high drug bioavailability. With advancements in formulation technologies, the drug-loading capability of microneedles can be improved.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2021)

Review Biotechnology & Applied Microbiology

The challenge and prospect of mRNA therapeutics landscape

Yuhua Weng et al.

BIOTECHNOLOGY ADVANCES (2020)

Article Chemistry, Medicinal

Efficiency of Chitosan/Hyaluronan-Based mRNA Delivery Systems In Vitro: Influence of Composition and Structure

Ousamah Younoss Soliman et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

A Thermostable mRNA Vaccine against COVID-19

Na-Na Zhang et al.

Review Medicine, Research & Experimental

Therapeutic applications of selenium nanoparticles

Amit Khurana et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Polymer Science

pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2019)

Review Biotechnology & Applied Microbiology

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Giulietta Maruggi et al.

MOLECULAR THERAPY (2019)

Article Multidisciplinary Sciences

An ingestible self-orienting system for oral delivery of macromolecules

Alex Abramson et al.

SCIENCE (2019)

Article Chemistry, Multidisciplinary

Triplex DNA Nanoswitch for pH-Sensitive Release of Multiple Cancer Drugs

Xiaoxia Chen et al.

ACS NANO (2019)

Review Pharmacology & Pharmacy

Carbon dots: Applications in bioimaging and theranostics

Kofi Oti Boakye-Yiadom et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Biotechnology & Applied Microbiology

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

Anirudh Sharma et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Yingshan Qiu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Chemistry, Multidisciplinary

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Asha Kumari Patel et al.

ADVANCED MATERIALS (2019)

Article Biochemistry & Molecular Biology

Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery

Jingxuan Yan et al.

MACROMOLECULAR BIOSCIENCE (2019)

Article Pharmacology & Pharmacy

Mechanism investigation of ethosomes transdermal permeation

Xiao-Qian Niu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS-X (2019)

Review Chemistry, Multidisciplinary

Functionalized gold nanostructures: promising gene delivery vehicles in cancer treatment

Sanjay Kumar et al.

RSC ADVANCES (2019)

Article Biochemistry & Molecular Biology

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

James Ashley et al.

Review Medicine, Research & Experimental

Mechanism of intranasal drug delivery directly to the brain

Tyler P. Crowe et al.

LIFE SCIENCES (2018)

Article Chemistry, Physical

Co-delivery of mRNA and SPIONs through amino-este nanomaterials

Xiao Luo et al.

NANO RESEARCH (2018)

Review Chemistry, Physical

Recent advances in mRNA vaccine delivery

Lu Tan et al.

NANO RESEARCH (2018)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells

Shuang Peng et al.

NATURE COMMUNICATIONS (2018)

Article Medicine, Research & Experimental

Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

Sonia Golombek et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Article Chemistry, Multidisciplinary

Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

Peng Sun et al.

CHEMICAL COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles

Yulia Zhitnyuk et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Materials Science, Biomaterials

Covalent and injectable chitosan-chondroitin sulfate hydrogels embedded with chitosan microspheres for drug delivery and tissue engineering

Ming Fan et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Article Medicine, Research & Experimental

From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery

Yingshan Qiu et al.

MOLECULAR PHARMACEUTICS (2017)

Review Biotechnology & Applied Microbiology

Selenium nanoparticles: potential in cancer gene and drug delivery

Fiona Maiyo et al.

NANOMEDICINE (2017)

Review Immunology

Major findings and recent advances in virus like particle (VLP)-based vaccines

Mona O. Mohsen et al.

SEMINARS IN IMMUNOLOGY (2017)

Review Chemistry, Inorganic & Nuclear

Metal-organic frameworks for biosensing and bioimaging applications

Huai-Song Wang

COORDINATION CHEMISTRY REVIEWS (2017)

Article Nanoscience & Nanotechnology

Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo

Xinfu Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Review Pharmacology & Pharmacy

Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes

Chensu Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Article Biochemistry & Molecular Biology

Efficient ex vivo delivery of chemically modified messenger RNA using lipofection and magnetofection

Zohreh Sadat Badieyan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Pharmacology & Pharmacy

Clinical potential of electroporation for gene therapy and DNA vaccine delivery

Laure Lambricht et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

Review Pharmacology & Pharmacy

Multifunctional hybrid-carbon nanotubes: new horizon in drug delivery and targeting

Neelesh Kumar Mehra et al.

JOURNAL OF DRUG TARGETING (2016)

Review Biotechnology & Applied Microbiology

Vectors and strategies for nonviral cancer gene therapy

Jessica Pahle et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

Article Chemistry, Multidisciplinary

Materials for non-viral intracellular delivery of messenger RNA therapeutics

Kevin J. Kauffman et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Review Materials Science, Multidisciplinary

Selenium nanomaterials: An overview of recent developments in synthesis, properties and potential applications

Savita Chaudhary et al.

PROGRESS IN MATERIALS SCIENCE (2016)

Review Pharmacology & Pharmacy

mRNA vaccine delivery using lipid nanoparticles

Andreas M. Reichmuth et al.

THERAPEUTIC DELIVERY (2016)

Review Chemistry, Multidisciplinary

Nanoparticles in Photodynamic Therapy

Sasidharan Swarnalatha Lucky et al.

CHEMICAL REVIEWS (2015)

Review Pharmacology & Pharmacy

Protamine-oligonucleotide-nanoparticles: Recent advances in drug delivery and drug targeting

B. Scheicher et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Article Chemistry, Multidisciplinary

Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles

Miyuki Baba et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Multidisciplinary

Nanotechnology approaches for inhalation treatment of lung diseases

Andriy Kuzmov et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Materials Science, Biomaterials

mRNA delivery using non-viral PCL nanoparticles

Ilaria E. Palama et al.

BIOMATERIALS SCIENCE (2015)

Article Medicine, Research & Experimental

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles

Anne Prel et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2015)

Article Chemistry, Multidisciplinary

pH-Responsive Drug-Delivery Systems

Ying-Jie Zhu et al.

CHEMISTRY-AN ASIAN JOURNAL (2015)

Review Immunology

Lipid-based mRNA vaccine delivery systems

Patrick Midoux et al.

EXPERT REVIEW OF VACCINES (2015)

Review Pharmacology & Pharmacy

Advances in Device and Formulation Technologies for Pulmonary Drug Delivery

John Gar Yan Chan et al.

AAPS PHARMSCITECH (2014)

Review Chemistry, Multidisciplinary

DNA Nanotechnology Based on i-Motif Structures

Yuanchen Dong et al.

ACCOUNTS OF CHEMICAL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROS-mediated DNA damage and ERK and AKT pathways

Qiang Xie et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Review Pharmacology & Pharmacy

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

Raquel P. Deering et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

Article Chemistry, Physical

The Investigation of Sequence-dependent Interaction of Messenger RNA Binding to Carbon Nanotube

M. Monajjemi et al.

FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES (2014)

Review Biotechnology & Applied Microbiology

Gold Nanoparticles for Nucleic Acid Delivery

Ya Ding et al.

MOLECULAR THERAPY (2014)

Review Biotechnology & Applied Microbiology

mRNA-based therapeutics - developing a new class of drugs

Ugur Sahin et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Editorial Material Polymer Science

In situ-forming injectable hydrogels for regenerative medicine

Jeong-A. Yang et al.

PROGRESS IN POLYMER SCIENCE (2014)

Article Multidisciplinary Sciences

Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity

Kyle K. L. Phua et al.

SCIENTIFIC REPORTS (2014)

Review Pharmacology & Pharmacy

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting

Chandrakantsing Vijaysing Pardeshi et al.

EXPERT OPINION ON DRUG DELIVERY (2013)

Article Medicine, Research & Experimental

Modified Foxp3 mRNA protects against asthma through an IL-10 dependent mechanism

Lauren E. Mays et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Pharmacology & Pharmacy

Nanotechnology approaches for inhalation treatment of fibrosis

Ronak Savla et al.

JOURNAL OF DRUG TARGETING (2013)

Review Biochemistry & Molecular Biology

Construction and Characterization of Virus-Like Particles: A Review

Andris Zeltins

MOLECULAR BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

Jerome Gilleron et al.

NATURE BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Efficient genome editing in zebrafish using a CRISPR-Cas system

Woong Y. Hwang et al.

NATURE BIOTECHNOLOGY (2013)

Article Biochemistry & Molecular Biology

Light-Controlled Modulation of Gene Expression Using Polyamidoamine Formulations

Sigurd Leinaes Boe et al.

NUCLEIC ACID THERAPEUTICS (2013)

Review Pharmacology & Pharmacy

Monolayer coated gold nanoparticles for delivery applications

Subinoy Rana et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Review Oncology

Targeted immunotherapy of cancer with CAR T cells: achievements and challenges

Grazyna Lipowska-Bhalla et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

Review Chemistry, Multidisciplinary

Metal-Organic Frameworks in Biomedicine

Patricia Horcajada et al.

CHEMICAL REVIEWS (2012)

Review Chemistry, Multidisciplinary

Mesoporous silica nanoparticles in biomedical applications

Zongxi Li et al.

CHEMICAL SOCIETY REVIEWS (2012)

Review Chemistry, Multidisciplinary

Nasal drug delivery - Recent developments and future prospects

Lisbeth Illum

JOURNAL OF CONTROLLED RELEASE (2012)

Article Biotechnology & Applied Microbiology

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

Benjamin Petsch et al.

NATURE BIOTECHNOLOGY (2012)

Review Chemistry, Multidisciplinary

Nanoscale Metal-Organic Frameworks for Biomedical Imaging and Drug Delivery

Joseph Della Rocca et al.

ACCOUNTS OF CHEMICAL RESEARCH (2011)

Article Biochemistry & Molecular Biology

A new RNA vaccine platform based on MS2 virus-like particles produced in Saccharomyces cerevisiae

Shipeng Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemical Research Methods

Graphene Oxide-Polyethylenimine Nanoconstruct as a Gene Delivery Vector and Bioimaging Tool

Hyunwoo Kim et al.

BIOCONJUGATE CHEMISTRY (2011)

Article Oncology

Photodynamic Therapy of Cancer: An Update

Patrizia Agostinis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

Review Biochemistry & Molecular Biology

Chitosan and its derivatives for gene delivery

N. Saranya et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2011)

Review Chemistry, Multidisciplinary

mRNA as gene therapeutic: How to control protein expression

Geertrui Tavernier et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Article Biochemistry & Molecular Biology

pH-responsive, DNA-directed reversible assembly of graphene oxide

Konggang Qu et al.

MOLECULAR BIOSYSTEMS (2011)

Article Medicine, Research & Experimental

In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

Xingfang Su et al.

MOLECULAR PHARMACEUTICS (2011)

Article Biotechnology & Applied Microbiology

Protein Transfer Into Human Cells by VSV-G-induced Nanovesicles

Philippe-Emmanuel Mangeot et al.

MOLECULAR THERAPY (2011)

Review Biotechnology & Applied Microbiology

Magnetic targeting strategies in gene delivery

Evgenya Delyagina et al.

NANOMEDICINE (2011)

Article Biotechnology & Applied Microbiology

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Michael S. D. Kormann et al.

NATURE BIOTECHNOLOGY (2011)

Article Biochemistry & Molecular Biology

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Kariem Ezzat et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Virology

Paleovirology - ghosts and gifts of viruses past

Maulik R. Patel et al.

CURRENT OPINION IN VIROLOGY (2011)

Review Pharmacology & Pharmacy

Chitosan-based formulations for delivery of DNA and siRNA

Shirui Mao et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

Article Chemistry, Multidisciplinary

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

Arivazhagan Rajendran et al.

CHEMICAL COMMUNICATIONS (2010)

Review Pharmacology & Pharmacy

Functionalized carbon nanotubes for potential medicinal applications

Yi Zhang et al.

DRUG DISCOVERY TODAY (2010)

Review Immunology

Virus-like particles in vaccine development

Antonio Roldao et al.

EXPERT REVIEW OF VACCINES (2010)

Article Chemistry, Multidisciplinary

PH-Controlled Carbon Nanotube Aggregation/Dispersion Based on Intermolecular I-Motif DNA Formation

Enjun Cheng et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2010)

Review Medicine, Research & Experimental

pH-Responsive Nanoparticles for Drug Delivery

Weiwei Gao et al.

MOLECULAR PHARMACEUTICS (2010)

Review Biochemistry & Molecular Biology

Light-Induced Gene Expression Using Messenger RNA Molecules

Sigurd Boe et al.

OLIGONUCLEOTIDES (2010)

Review Chemistry, Physical

Injectable, Biodegradable Hydrogels for Tissue Engineering Applications

Huaping Tan et al.

MATERIALS (2010)

Review Pharmacology & Pharmacy

Nanoparticles for nasal vaccination

Noemi Csaba et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

Article Chemistry, Multidisciplinary

A pH-Triggered, Fast-Responding DNA Hydrogel

Enjun Cheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Review Chemistry, Multidisciplinary

Nucleic acid delivery with chitosan and its derivatives

Wing-Fu Lai et al.

JOURNAL OF CONTROLLED RELEASE (2009)

Review Pharmacology & Pharmacy

Gold nanoparticles in delivery applications

Partha Ghosh et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

Review Biochemistry & Molecular Biology

Retrotransposons revisited: The restraint and rehabilitation of parasites

John L. Goodier et al.

Article Engineering, Biomedical

Engineering strategies to enhance nanoparticle-mediated oral delivery

Yvonne J. Yamanaka et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2008)

Article Chemistry, Multidisciplinary

PEGylated nanographene oxide for delivery of water-insoluble cancer drugs

Zhuang Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Biotechnology & Applied Microbiology

Tumor-targeted delivery of siRNA by self-assembled nanoparticles

Shyh-Dar Li et al.

MOLECULAR THERAPY (2008)

Review Biotechnology & Applied Microbiology

Transdermal drug delivery

Mark R. Prausnitz et al.

NATURE BIOTECHNOLOGY (2008)

Article Chemistry, Multidisciplinary

Use of the interparticle i-motif for the controlled assembly of gold nanoparticles

Wenxing Wang et al.

LANGMUIR (2007)

Review Biotechnology & Applied Microbiology

Inhaling medicines: delivering drugs to the body through the lungs

John S. Patton et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Immunology

Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA

Birgit Scheel et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2006)

Review Pharmacology & Pharmacy

Is the oral route possible for peptide and protein drug delivery

Mariko Morishita et al.

DRUG DISCOVERY TODAY (2006)

Review Polymer Science

Chitin and chitosan: Properties and applications

Marguerite Rinaudo

PROGRESS IN POLYMER SCIENCE (2006)

Article Chemistry, Physical

Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer

N Nishiyama et al.

NATURE MATERIALS (2005)

Article Immunology

Immunostimulating capacities of stabilized RNA molecules

B Scheel et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2004)

Review Biotechnology & Applied Microbiology

Current status and future potential of transdermal drug delivery

MR Prausnitz et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Article Biochemistry & Molecular Biology

Many commonly used siRNAs risk off-target activity

O Snove et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Review Biochemistry & Molecular Biology

Adenovirus and adeno-associated virus vectors

CM Lai et al.

DNA AND CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

F Scherer et al.

GENE THERAPY (2002)

Article Biochemistry & Molecular Biology

Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH

N Fang et al.

BIOMACROMOLECULES (2001)

Article Biochemistry & Molecular Biology

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells

T Bettinger et al.

NUCLEIC ACIDS RESEARCH (2001)

Article Biotechnology & Applied Microbiology

Enhancement of transfection by physical concentration of DNA at the cell surface

D Luo et al.

NATURE BIOTECHNOLOGY (2000)

Article Biotechnology & Applied Microbiology

Photochemical transfection: A new technology for light-induced, site-directed gene delivery

A Hogset et al.

HUMAN GENE THERAPY (2000)

Review Chemistry, Multidisciplinary

Monolayer protected cluster molecules

AC Templeton et al.

ACCOUNTS OF CHEMICAL RESEARCH (2000)