A unique association? A narcolepsy type 1 case comorbid with Primary Biliary Cholangitis

The aim of the study was to present a woman affected of a narcolepsy with cataplexy (narcolepsy type 1) co morbid with an asymptomatic Primary Biliary Cholangitis (PBC). The HLA haplotype was DRB1*15:01, DQA1*01:02, DQB1*06:02. The allele DQB1*06:02 has been considered until now protective for PBC and dual pathology has not been published.We think the important clinical message of the Case would be of continuing to monitor adults with narcolepsy type 1 for late complications that may be associated with other autoimmune conditions. Clinicians should be aware of the relationship between Narcolepsy and PBC. This highlights the need for screening and management in these individuals.

Automated summary

The aim of this study was to report a case of a woman with narcolepsy type 1 co-morbid with asymptomatic primary biliary cholangitis (PBC). The important clinical message of this case is the need to monitor adults with narcolepsy type 1 for late complications associated with other autoimmune conditions. Clinicians should be aware of the relationship between narcolepsy and PBC, and screening and management in these individuals is necessary.