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News Item
Biotechnology & Applied Microbiology
Asher Mullard
Summary: Clinic-ready inhibitors, degraders and molecular glues are advancing cancer research by specifically targeting KRAS variants, such as KRAS-G12D.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Article
Chemistry, Analytical
Liang Zhu et al.
Summary: In this study, an ultrasensitive electrochemical biosensor was constructed using a high-efficiency Y-shaped DNA walker with abundant recognition domains. The Y-shaped DNA walker could be synthesized through rolling circle amplification with the assistance of padlock, and it showed significantly higher cleavage efficiency compared to conventional Y-shaped walkers. The biosensor achieved ultrasensitive detection of miRNA-21 with a detection limit of 10.6 aM, indicating its potential for sensitive detection of biomarkers and early diagnosis of diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biophysics
Mingxuan Li et al.
Summary: A novel ECL biosensor was developed using bimetallic MXene derivative QDs (Mo2TiC2 QDs) and SnS2 nanosheets/lipid bilayer for detecting gastric cancer marker miRNA-27a-3p. The Mo2TiC2 QDs provided superior luminous intensity and better stability, while the SnS2 nanosheets enhanced the luminous intensity and improved the stability of the lipid bilayer. The sensing system displayed high sensitivity and good reproducibility, with a wide linear correlation range from 1 fM to 10 nM and a low detection limit of 1 fM. This biosensor has great potential for clinical applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Biomedical
WanWan Lv et al.
Summary: Albumin-based hydrogels have been developed as promising systems for delivering hydrophobic anticancer drugs. This study presents a new strategy for synthesizing a crosslinkable albumin-based hydrogel (CABH) using N-hydroxysuccinimide (NHS)-activated linker. The CABH exhibits improved physiochemical characteristics and drug release.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zhimei Huang et al.
Summary: DNAwalkers have been widely used in biosynthesis, biocomputing, and biosensing due to their programmability, biocompatibility, and signal amplification capacity. A dual spatially localized DNA walker was designed to drive high-speed stochastic movement along three-dimensional tracks using bipedal catalysts. The colocalization of autocatalytic circuits and the use of bipedal catalysts significantly increased the reaction kinetics. An RNA-responsive PCHA walker was constructed for mRNA imaging in live cells, providing a novel and efficient tool for biomolecule detection and biological functions regulation.
Article
Chemistry, Analytical
Jinglan Cao et al.
Summary: In this study, a new amplified electrochemical biosensor was developed for the sensitive assay of Sonic Hedgehog (SHh) protein. The biosensor, based on the combination of a SHh-specific aptamer and primer exchange reaction (PER) and catalytic hairpin assembly (CHA), enables the detection of SHh with a detection limit of 4.1 pM. The biosensor can be utilized for the detection of low concentrations of SHh in human serum diluent, making it a potential tool for disease diagnosis and prognosis evaluation.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biotechnology & Applied Microbiology
Yunshan Zhang et al.
Summary: In this study, TiO2 nanotubes of different sizes were grown using anodization method and their drug loading and release profile as well as antitumor efficiency were investigated. The larger TiO2 nanotubes showed improved drug-loading capacity and cell-killing ability compared to smaller ones. These findings suggest that larger TiO2 nanotubes have potential as therapeutic carriers for improved cancer treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biophysics
Wenjian Yang et al.
Summary: Preclinical investigation of drug-induced cardiotoxicity is crucial for drug development. A biosensing system that employs nonlinear dynamic analysis-assisted neural network (NDANN) is presented to directly extract features from beating signal time series for drug-induced cardiotoxicity assessment. This system achieves high accuracy in identifying drug-induced cardiotoxicity and can be a new screening platform for newly developed drugs.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Aidan J. Canning et al.
Summary: This article presents a highly reproducible and robust plasmonic bimetallic nanostar biosensing platform utilizing surface-enhanced Raman scattering (SERS) for sensitive detection of miRNA targets. The platform is capable of distinguishing between healthy and cancerous patient samples, as confirmed by PCR data.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Wei-Ting Chen et al.
Summary: In recent years, there has been an increasing demand for rapid, sensitive, and simple methods for diagnosing DNA due to the rise in infectious disease variations. This study introduces a flash signal amplification method combined with electrochemical detection for PCR-free tuberculosis molecular diagnosis. By utilizing the properties of butanol and water, we were able to concentrate the necessary components for DNA detection quickly, reducing reaction time. The developed method shows high sensitivity and specificity, capable of detecting low levels of DNA targets and is successfully applied in tuberculosis diagnosis.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Yuanfeng Pang et al.
Summary: By combining CRISPR-Cas12a and SERS technology, the sensitivity and specificity of LFA nucleic acid detection have been improved, allowing for direct quantification of HIV-1 dsDNA in less than 1 hour and recognition of HIV-1 single-base drug resistance mutations. This paper-based CRISPR-SERS strip has great potential for point-of-care testing in resource-poor or non-laboratory environments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Oncology
Albert K. Kwan et al.
Summary: This article reviews the development of KRAS inhibitors, including the discovery and structure of the RAS family of oncoproteins, the clinical relevance of KRAS in human cancer, particularly the KRAS(G12C) mutation, and the ongoing clinical trials of direct KRAS(G12C) inhibitors.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Analytical
Haiping Wu et al.
Summary: This article presents an alternative analysis platform, dNASA, which is based on digital nucleic acid signal amplification in droplets. By using a bead-based controllable extension bridged cascade signal amplification reaction, the platform achieves highly efficient and specific nucleic acid signal amplification. The feasibility of the platform was demonstrated in single-base DNA mutation analysis.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yunshan Zhang et al.
Summary: This study characterized the chain structure of selenium polysaccharide (Se-POP-3) and investigated its anti-gastric cancer and anti-colon cancer effects. Results showed that Se-POP-3 had inhibitory effects on cancer cells and no significant effect on normal cells. This study provides a theoretical basis for the potential application of Se-POP-3 as an anti-gastrointestinal cancer drug or functional food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Lu Song et al.
Summary: DNA nanomaterials, with the ability to design arbitrary shapes and controllable motions, have been widely used to construct diverse nanomachines. Among them, DNA walkers are popular nanodevices with ingenious design and flexible function, showing great potential in biosensing applications.
Article
Biophysics
Yaokun Xia et al.
Summary: A dual-signal amplification biosensor was developed for sensitive detection of exosomal miRNA-21. With two rounds of signal amplification, the biosensor achieved a low detection limit for miRNA-21 and demonstrated high discrimination ability in clinical samples, with an accuracy of 83.9% in distinguishing gastric cancer and precancerous lesions.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Su Jiang et al.
Summary: In this study, a novel method was developed for sensitive detection of miRNA in lung tissues by target-triggered assembly of G-quadruplex DNAzyme nanowires. This method exhibited high sensitivity, a large dynamic range, and the ability to distinguish single-base mutations, holding promising applications in biomedical analysis and cancer prognosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Ting Zhang et al.
Summary: This study presents a paper-based assay for the rapid colorimetric detection of SARS-CoV-2 variants. The assay utilizes nucleic acid reactions and enzymatic amplification to detect different variants of the virus within 30 minutes. The results show 100% concordance with other commonly used detection methods. This customizable and inexpensive paper-based assay could facilitate viral surveillance.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Xiaolong Li et al.
Summary: This study describes an amplified and highly sensitive fluorescent strategy based on CHA for detecting SNPs in the K-ras gene, with substantial discrimination capability. This method has significant implications in drug design and disease diagnosis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biophysics
Hai-Yan Jia et al.
Summary: A versatile and sensitive miRNA detection platform based on CRISPR/Cas12a system and hybridization chain reaction (HCR) circuit was developed. The platform converts miRNA into activators through the HCR circuit, enabling sensitive detection of different miRNAs. The platform demonstrated consistency with RT-qPCR results and potential for clinical diagnosis of cancers and therapy monitoring.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Yi Xu et al.
Summary: In this study, a CRISPR-electrochemical biosensor based on a three-dimensional tetrahedral DNA framework was constructed for the simple, amplification-free, and sensitive detection of low-expression miRNA-19b. The activation, cleavage, and signal readout processes were all carried out on the chip using CRISPR/Cas13a, making it suitable for POC testing.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Nanoscience & Nanotechnology
Zhen Song et al.
Summary: This study introduces a disposable genosensor utilizing nanosized germananes for sensitive and selective detection of Alzheimer-related SNP, with germanane showing excellent bioanalytical performance. The potential for miniaturization and decentralized analysis is demonstrated, highlighting the versatility and promise of germanene-based nanomaterials in biosensing applications.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Analytical
Miriam Jauset-Rubio et al.
Summary: Isothermal recombinase polymerase amplification-based solid-phase primer extension is utilized for the optical detection of a single nucleotide polymorphism related to hypertrophic cardiomyopathy in fingerprick blood samples. By optimizing the percentage of biotinylated dNTPs and the duration of primer extension, the SNP in the fingerprick sample was identified successfully. Ongoing work is focused on expanding the technology to the multiplexed detection of SNPs in fingerprick and other biological samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Chen-Chen Li et al.
Summary: A quantum dot-mediated fluorescence nanosensor was developed for sensitive detection of SNPs in cancer cells, offering high amplification efficiency, zero background signal, good specificity, and high sensitivity. It can detect a wide range of SNPs and accurately identify mutations as low as 0.001% in mixtures, achieving single-cell level SNP quantification.
ANALYTICAL CHEMISTRY
(2021)
Meeting Abstract
Oncology
Francesca Battaglin et al.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Chemistry, Analytical
Liyan Zhang et al.
Summary: A bipedal-unequivalent three-dimensional DNA walker was designed and applied for biosensing, showing twice the sustainable operation capability compared to other types of DNA walkers. Using let-7a as a model target, it demonstrated a detection limit of 68 pM and satisfactory reproducibility in biological fluids, making it a potential analytical tool in clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Yan Zhang et al.
Summary: This enzyme-free single-molecule/particle detection method enables simultaneous detection of multiple lncRNAs in cancer cells with dual-targetability, good selectivity, and high sensitivity, even in single cancer cells. It has the ability to discriminate cancer cells from normal cells, features simple sequence design and enzyme-free, holding great potential in living cell imaging and early clinical diagnosis.
Article
Biophysics
Fan Jia et al.
Summary: Signal amplification is crucial for high-performance electrochemical sensors, but can be complex for ratiometric detections. This study introduces a ratiometric electrochemical aptasensor for AFB1 using a dual-amplification strategy involving DNA walker and hybridization chain reaction, enabling accurate detection in the 0.003-3 pg/mL range.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Xin Liu et al.
Summary: The work has developed a simple and reliable platform for simultaneous analysis of telomerase and miRNA using a three-dimensional bipedal DNA walking strategy. With the advantages of fast, sensitive and selective analysis, the method has great potential for early clinical diagnosis applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yunshan Zhang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Multidisciplinary
Lei Yang et al.
Article
Chemistry, Multidisciplinary
Xiaolong Yang et al.
Article
Chemistry, Analytical
Muling Shi et al.
ANALYTICAL CHEMISTRY
(2015)
Article
Chemistry, Analytical
Feng Chen et al.
ANALYTICAL CHEMISTRY
(2015)
Article
Chemistry, Analytical
Hong-Qi Wang et al.
ANALYTICAL CHEMISTRY
(2011)
Meeting Abstract
Oncology
H. Bai et al.
JOURNAL OF CLINICAL ONCOLOGY
(2010)
