4.7 Article

Aptasensing of beta-amyloid (A beta((1-42))) by a 3D-printed platform integrated with leaf-shaped gold nanodendrites

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Electrochemistry

3D printed electrodes design and voltammetric response

William B. Veloso et al.

Summary: The limitations in the voltammetric response of 3D printed electrodes are studied using numerical simulations and new electrode designs. Severe diffusion limitations are found in a commonly used 3D printed electrode and electrochemical cell design, hindering the investigation of electron transfer kinetics. A new non-recessed electrode design is used to study the voltammetric response without mass transport limitations, revealing that the response is limited by contact resistance. By considering contact resistance and finite electron transfer kinetics, the peak potentials and currents of voltammograms recorded with 3D printed electrodes can be predicted before printing, allowing for optimized electrode designs in the virtual space.

ELECTROCHIMICA ACTA (2023)

Article Chemistry, Analytical

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

Masoud Negahdary et al.

Summary: By utilizing aptamer-conjugated gold nanoparticles (aptamer-AuNPs) and a modified glassy carbon electrode (GCE) with reduced graphene oxide (rGO) and Acropora-like gold (ALG) nanostructure, a sandwich-like system is developed for sensitive detection of heat shock protein 70 kDa (HSP70) as a functional biomarker in COVID-19 diagnosis/prognosis. The designed aptasensor demonstrates a wide linear range (5 pg mL(-1) to 75 ng mL(-1)) with a low limit of detection (LOD) of approximately 2 pg mL(-1). The aptasensor exhibits stability for 3 weeks and shows promise in detecting HSP70 in real plasma samples from COVID-19 patients, with a diagnostic sensitivity of 90% and specificity of 85% compared to the RT-PCR method.

ANALYTICA CHIMICA ACTA (2023)

Article Biophysics

Functionalized graphene-based electrochemical array sensors for the identification of distinct conformational states of Amyloid Beta in Alzheimer's disease

Haiwei Ji et al.

Summary: In this study, an electrochemical array-based sensing platform was successfully constructed using functionalized graphene with different physicochemical features. The presence of A beta peptide led to a significant change in the electrochemical impedance signal due to the interference of the electro-insulated A beta species with electron transport. The constructed sensing platform demonstrated high accuracy in discriminating different A beta forms, mixtures of A beta forms, and different ratios of A beta 42 to A beta 40 by only using dual probes, and also showed excellent performance in screening A beta inhibitors and metal chelators.

BIOSENSORS & BIOELECTRONICS (2023)

Article Engineering, Environmental

Free-standing vertically aligned tin disulfide nanosheets for ultrasensitive aptasensor design toward Alzheimer?s diagnosis applications

Bayu Tri Murti et al.

Summary: In this study, an electrochemical biosensor for the detection of amyloid-beta (42) oligomers (A beta Os) in Alzheimer's disease is developed using tin disulfide nano-sheets. The biosensor shows high sensitivity and can detect A beta Os in physiological buffer and human serum. It also exhibits good stability and selectivity. The findings provide new insights for future advancements in Alzheimer's diagnosis.

CHEMICAL ENGINEERING JOURNAL (2023)

Review Chemistry, Multidisciplinary

Gold Nanomaterials-Implemented Wearable Sensors for Healthcare Applications

Jiuhong Yi et al.

Summary: This review provides an overview of recent advances in gold nanomaterials-implemented wearable sensors for healthcare applications, including fabrication methods, working mechanisms, and performance. Different types of wearable sensors are discussed, and future prospects and challenges of gold nanomaterials-implemented wearable sensors are also explored.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Analytical

Hybridization chain reaction triggered poly adenine to absorb silver nanoparticles for label-free electrochemical detection of Alzheimer's disease biomarkers amyloid β-peptide oligomers

Xianjiu Liao et al.

Summary: Researchers have developed a novel label-free electrochemical detection sensor for A beta O, which exhibits high selectivity for the target protein. The sensor is based on hybridization chain reaction-triggered poly adenine to absorb silver nanoparticles for subsequent electrochemical stripping.

ANALYTICA CHIMICA ACTA (2022)

Article Biophysics

Current progress in aptamer-based sensing tools for ultra-low level monitoring of Alzheimer's disease biomarkers

Javad Zamanian et al.

Summary: Alzheimer's disease is a common late-life dementia characterized by the deposition and accumulation of brain proteins. With no effective therapy available, the development of early diagnostic tools is crucial. Aptamer-based biosensors play a significant role in AD healthcare due to their excellent sensitivity and specificity.

BIOSENSORS & BIOELECTRONICS (2022)

Editorial Material Pharmacology & Pharmacy

Blood-Based Alzheimer's Biomarkers

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

Review Materials Science, Biomaterials

Electrochemical aptamer-based nanobiosensors for diagnosing Alzheimer's disease: A review

Masoud Negahdary et al.

Summary: This review summarizes recent developments in electrochemical nanoaptasensors for the diagnosis and prognosis of Alzheimer's disease. The use of nanomaterials in these aptasensors has greatly enhanced their sensitivity, amplifying the output signals and improving their diagnostic capabilities.

BIOMATERIALS ADVANCES (2022)

Review Engineering, Chemical

Polymer-based microfluidic devices: A comprehensive review on preparation and applications

Xue Han et al.

Summary: Microfluidics devices are key components in the field of life science, particularly in the area of label-free detection. Polymer materials are commonly used for their versatile fabrication methods and low cost. Various methods such as lithography and 3D printing are used in the fabrication of polymer microfluidic systems, showcasing merits and demerits of each method. Applications of polymer-based microfluidic systems include blood testing, tumor cell detection, oil adsorption testing, and pesticide detection, with a focus on device preparation methods and application scenarios.

POLYMER ENGINEERING AND SCIENCE (2022)

Article Clinical Neurology

Brain 18F-Florbetapir PET/CT Findings in an Early-onset Alzheimer Disease Patient Carrying Presenilin-1 G378E Mutation

Angelina Cistaro et al.

Summary: Positron emission tomography (PET) with F-18-Fluorodeoxyglucose (F-18-FDG) is essential for diagnosing dementia, and amyloid PET imaging is helpful for early detection of Alzheimer disease (AD). This study presents the first report of F-18-Florbetapir amyloid imaging in a 35-year-old male patient with early-onset Alzheimer disease (EOAD). The findings support the usefulness of amyloid PET imaging in diagnosing EOAD.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2022)

Review Engineering, Electrical & Electronic

3-D Electrodes for Electrochemical Sensors: Review in Different Approaches

Mohamed Abdelkader et al.

Summary: With the growing demand for miniaturized devices, the emergence of 3-D printing techniques for creating sensors has become a trend in recent years. This review summarizes the most commonly used technologies for creating electrochemical sensors, including 3-D printing, plating, and composite formation. It also provides an overview of the fabrication and applications reported in 2020 and 2021, as well as insights into future directions.

IEEE SENSORS JOURNAL (2022)

Review Chemistry, Multidisciplinary

Nanotechnology for the diagnosis and treatment of Alzheimer's disease: A bibliometric analysis

Li Li et al.

Summary: This review provides a brief overview and analysis of the development of nanotechnology in Alzheimer's disease (AD). Through bibliometric analysis, the publishing trend, countries/institutions, reference sources, and research hotspots of AD-related nanotechnology are analyzed and visualized. The key roles of nanotechnology in both diagnostic and therapeutic aspects of AD are summarized, along with the potential nanotoxicity of nanomaterials. The review also highlights the prospects for the development of nanotechnology in AD applications.

NANO TODAY (2022)

Article Biophysics

Current trends in blood biomarker detection and imaging for Alzheimer's disease

Shun Hu et al.

Summary: This article discusses the development trend of blood biomarker detection technologies related to Alzheimer's disease (AD) and explores the potential of combined detection with optoelectronic and imaging technologies in clinical diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

Article Neurosciences

Abnormal Functional Connectivity of Thalamic Subdivisions in Alzheimer?s Disease: A Functional Magnetic Resonance Imaging Study

Yue Wu et al.

Summary: This study examined dysfunction in the functional connectivity of thalamic subdivisions in patients with Alzheimer's disease (AD) and its relationship with clinical assessments. The results showed decreased functional connectivity between the intralaminar and medial thalamus and the precuneus in AD patients, which was correlated with cognitive performance. These findings suggest that dysfunction in the thalamus may contribute to cognitive impairment in AD and could be a potential target for treatment.

NEUROSCIENCE (2022)

Article Chemistry, Analytical

An aptasensing platform for detection of heat shock protein 70 kDa (HSP70) using a modified gold electrode with lady fern-like gold (LFG) nanostructure

Masoud Negahdary et al.

Summary: In this study, the first aptasensor for detecting HSP70 was developed using a modified gold electrode with lady fern-like gold nanostructure. The aptasensor showed high sensitivity and selectivity, and could detect HSP70 in a wide linear range.

TALANTA (2022)

Review Biochemistry & Molecular Biology

Staging of Alzheimer?s disease: past, present and future perspectives

Joseph Therriault et al.

Summary: For many years, Alzheimer's disease has been primarily associated with dementia, but recent studies have shown that AD patients go through a long preclinical phase before cognitive decline, which can be staged using imaging and biomarkers.

TRENDS IN MOLECULAR MEDICINE (2022)

Article Clinical Neurology

Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment

Cherie Strikwerda-Brown et al.

Summary: The study confirmed the clinical value of NIA-AA biological research criteria in predicting whether older individuals with no cognitive impairment will develop AD symptoms in the near future, with most A+T+(N+) individuals developing AD symptoms within 2 to 3 years.

JAMA NEUROLOGY (2022)

Article Biophysics

Ultrasensitive probeless capacitive biosensor for amyloid beta (Aβ1-42) detection in human plasma using interdigitated electrodes

Parshant Kumar Sharma et al.

Summary: The study developed a highly sensitive and novel method to detect Aβ, a hallmark biomarker of AD, using an interdigitated capacitive biosensor. The results showed that the biosensor exhibited good specificity and sensitivity, enabling real-time detection of oAβ in the femto-molar range. Additionally, the fabricated capacitive biochip demonstrated long-term stability and suitability for point-of-care diagnostic applications.

BIOSENSORS & BIOELECTRONICS (2022)

Review Chemistry, Analytical

Design strategies, current applications and future perspective of aptasensors for neurological disease biomarkers

Cem Erkmen et al.

Summary: The increasing incidence of neurological diseases presents a major challenge for society. Aptasensors, which utilize aptamers as biorecognition elements, show great potential for early detection and diagnosis of neurological diseases. This review provides an overview of recent progress on aptasensors for biomarker detection in neurological diseases, including construction principles, signal transduction methods, performance properties, and applications.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

Review Chemistry, Physical

A review of 3D printing technology for rapid medical diagnostic tools

Sara Shakibania et al.

Summary: Early diagnosis of diseases is crucial in selecting appropriate treatments, preventing problems, and stopping the spread of diseases. Additive manufacturing (AM) or 3D printing technology has been widely used in biomedical applications, providing highly precise and economical diagnostic tools with complex geometries.

MOLECULAR SYSTEMS DESIGN & ENGINEERING (2022)

Review Clinical Neurology

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Charlotte E. Teunissen et al.

Summary: Recent research suggests that blood-based biomarkers for Alzheimer's disease may become a reality, with consistent results across different cohorts. Additionally, other blood-based biomarkers can provide information about disease progression and treatment effects.

LANCET NEUROLOGY (2022)

Article Engineering, Environmental

Reagentless and sub-minute laser-scribing treatment to produce enhanced disposable electrochemical sensors via additive manufacture

Diego P. Rocha et al.

Summary: A new method using CO2 laser for surface treatment of carbon-black/PLA-based 3D-printed electrodes significantly improved their electrochemical performance, allowing for simultaneous detection of multiple compounds. The electrodes treated with this method showed promise for on-site detection and quantitative analysis with good recovery rates.

CHEMICAL ENGINEERING JOURNAL (2021)

Review Clinical Neurology

Alzheimer's disease associated with Down syndrome: a genetic form of dementia

Juan Fortea et al.

Summary: Adults with Down syndrome are at high risk of developing early-onset dementia, which is the leading cause of death in this population. Diagnosis of dementia remains a challenge due to lack of validated criteria, and biomarkers have shown good diagnostic performances with similar changes to Alzheimer's disease. Despite the lack of treatments to prevent Alzheimer's, unprecedented research in this area may lead to disease-modifying therapies.

LANCET NEUROLOGY (2021)

Review Biochemistry & Molecular Biology

The Amyloid-β Pathway in Alzheimer's Disease

Harald Hampel et al.

Summary: Breakthroughs in molecular medicine have highlighted the significance of the amyloid-beta pathway in the pathophysiology of Alzheimer's disease. Established biochemical alterations of the A beta cycle serve as promising targets for the development of disease-modifying therapies. Research indicates a crucial role of A beta pathway dyshomeostasis in the dynamics of AD pathophysiology, supporting the development of A beta-targeting therapeutic strategies for early treatment of AD.

MOLECULAR PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures

Sebastian Palmqvist et al.

Summary: Plasma P-tau, in combination with plasma phospho-tau and other biomarkers, along with clinical tests and APOE genotyping, can accurately predict the risk of Alzheimer's disease dementia, improving diagnostic prediction and facilitating recruitment for clinical trials.

NATURE MEDICINE (2021)

Review Neurosciences

Synergy between amyloid-β and tau in Alzheimer's disease

Marc Aurel Busche et al.

NATURE NEUROSCIENCE (2020)

Review Chemistry, Analytical

Electrochemical aptasensors based on the gold nanostructures

Masoud Negahdary

TALANTA (2020)

Article Multidisciplinary Sciences

Glycated albumin precipitation using aptamer conjugated magnetic nanoparticles

R. Fayazi et al.

SCIENTIFIC REPORTS (2020)

Review Environmental Sciences

Nanomaterials for the treatment and diagnosis of Alzheimer's disease: An overview

Muhammad Bilal et al.

NANOIMPACT (2020)

Review Materials Science, Multidisciplinary

Detection and beyond: challenges and advances in aptamer-based biosensors

Hyebin Yoo et al.

MATERIALS ADVANCES (2020)

Article Nanoscience & Nanotechnology

Development of DNA Aptamer as a β-Amyloid Aggregation Inhibitor

Yan Zheng et al.

ACS APPLIED BIO MATERIALS (2020)

Article Chemistry, Analytical

Aptamersvs.antibodies as capture probes in optical porous silicon biosensors

Sofia Arshavsky-Graham et al.

ANALYST (2020)

Article Chemistry, Analytical

An electrochemical troponin T aptasensor based on the use of a macroporous gold nanostructure

Masoud Negahdary et al.

MICROCHIMICA ACTA (2019)

Article Biotechnology & Applied Microbiology

An electrochemical troponin I peptisensor using a triangular icicle-like gold nanostructure

M. Negahdary et al.

BIOCHEMICAL ENGINEERING JOURNAL (2019)

Article Chemistry, Analytical

Monitoring amyloid-β proteins aggregation based on label-free aptasensor

Yuting Zhang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Article Biophysics

Electrochemical biosensing of 16s rRNA gene sequence of Enterococcus faecalis

R. Nazari-Vanani et al.

BIOSENSORS & BIOELECTRONICS (2019)

Article Chemistry, Analytical

Gold nanoparticle prepared by electrochemical deposition for electrochemical determination of gabapentin as an antiepileptic drug

Atieh Zabihollahpoor et al.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY (2019)

Article Chemistry, Physical

Physical Interpretations of Nyquist Plots for EDLC Electrodes and Devices

Bing-Ang Mei et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2018)

Article Chemistry, Inorganic & Nuclear

Green electrodeposition of gold nanostructures by diverse size, shape, and electrochemical activity

R. Dehdari Vais et al.

GOLD BULLETIN (2016)

Article Chemistry, Analytical

Selection of DNA Aptamers That Recognize α-Synuclein Oligomers Using a Competitive Screening Method

Kaori Tsukakoshi et al.

ANALYTICAL CHEMISTRY (2012)