4.7 Article

Rational design of α-glucosidase activated near-infrared fluorescent probe and its applications in diagnosis and treatment of diabetes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Spectroscopy

Design, synthesis, spectroscopic characterizations, antidiabetic, in silico and kinetic evaluation of novel curcumin-fused aldohexoses

Mohammad Ezati et al.

Summary: Curcumin has an important role in preventing various diseases, including diabetes. In this study, curcumin-fused aldohexose derivatives were synthesized and found to inhibit two enzymes related to hyperglycemia. Spectral analysis confirmed the formation of the target compounds. In vivo studies showed that one of the compounds could lower blood glucose levels in rats.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2023)

Article Spectroscopy

Inhibitory mechanism of phenolic compounds in rapeseed oil on α-amylase and α-glucosidase: Spectroscopy, molecular docking, and molecular dynamic simulation

Huihui Liu et al.

Summary: The important phenolic compounds from rapeseed oil were found to effectively inhibit a-amylase and a-glucosidase. The inhibition mechanism was non-competitive and involved hydrogen bonds, hydrophobic force, or 7L-7L interaction. These compounds-induced conformation alterations of the enzymes were confirmed by FT-IR and molecular dynamics.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2023)

Review Chemistry, Multidisciplinary

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Haidong Li et al.

Summary: The discovery of hemicyanine dyes as near-infrared fluorescent chromophores has significant implications in detection, bioimaging, and medical therapeutic applications. These dyes possess superior optical properties and structural tailorability, making them promising tools for monitoring biomolecules and diagnosing diseases.

CHEMICAL SOCIETY REVIEWS (2022)

Review Chemistry, Multidisciplinary

Activatable fluorescent probes for in situ imaging of enzymes

Xiaofeng Wu et al.

Summary: This article summarizes the methods for in situ imaging of enzymes using activatable fluorescent probes, and proposes that fluorescent probes with both activatable and in situ properties will facilitate high-resolution studies of enzymes in living systems.

CHEMICAL SOCIETY REVIEWS (2022)

Article Gastroenterology & Hepatology

Cultivated human intestinal fungus Candida metapsilosis M2006B attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists

Xiaokui Huo et al.

Summary: The study found that Candida spp had a higher abundance in patients with IBD. It was revealed that Candida metapsilosis M2006B significantly attenuated colitis in mice by activating farnesoid X receptor (FXR). The research identified two acyclic sesquiterpenoids (F4 and F5) as major active metabolites of M2006B that effectively treated experimental colitis by selectively activating FXR.
Article Biochemistry & Molecular Biology

Green preparation of holocellulose nanocrystals from burdock and their inhibitory effects against α-amylase and α-glucosidase

Ying Li et al.

Summary: The study found that the inhibitory effect of burdock nanocrystals on enzymes is positively correlated with their size, and static complexes are formed between the nanocrystals and enzymes through hydrophobic interactions and hydrogen bonding. During simulated digestion, the nanocrystals significantly delayed starch hydrolysis, showing potential in blocking postprandial blood glucose surge.

FOOD & FUNCTION (2022)

Article Nutrition & Dietetics

Effect of Type 2 Diabetes and Impaired Glucose Tolerance on Digestive Enzymes and Glucose Absorption in the Small Intestine of Young Rats

Lyudmila V. Gromova et al.

Summary: The study found that in young Wistar rats with type 2 diabetes and impaired glucose tolerance, the ability of the small intestine to absorb glucose increased, while there were significant changes in enzyme activity in the intestine.

NUTRIENTS (2022)

Review Microbiology

Carbohydrate-active enzymes (CAZymes) in the gut microbiome

Jacob F. Wardman et al.

Summary: This review discusses the diversity and functions of carbohydrate-active enzymes (CAZymes) in the human gut microbiota and their roles in human health and disease. It also highlights potential applications of these enzymes, such as improving microbiota health and treating diseases.

NATURE REVIEWS MICROBIOLOGY (2022)

Article Spectroscopy

Rapid prediction method of α-Glycosidase inhibitory activity of Coreopsis tinctoria extract from different habitats by near infrared spectroscopy

Xiaogang He et al.

Summary: A rapid prediction model for the inhibitory activity of Coreopsis tinctoria extract on alpha-Glucosidase was established based on near infrared spectroscopy. By selecting spectral preprocessing and optimizing spectral bands, the model effectively predicted the inhibition activity and showed a good fitting relationship with the reference inhibition value.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

Article Chemistry, Analytical

Emission enhancement of fluorescent glutathione-capped gold nanoclusters by cerium (III) ion-induced aggregation for sensitive detecting α-glucosidase in human serum using ratiometric fluorometry

Wei Zhang et al.

Summary: In this study, a fluorescence probe based on carbon dots and glutathione-capped gold nanoclusters was designed for detecting alpha-glucosidase in human serum. The probe showed a linear response to alpha-glucosidase activity and exhibited promising potential for clinical diagnosis.

MICROCHEMICAL JOURNAL (2022)

Article Chemistry, Analytical

Endoplasmic Reticulum-Targeting Near-Infrared Fluorescent Probe for CYP2J2 Activity and Its Imaging Application in Endoplasmic Reticulum Stress and Tumor

Xiangge Tian et al.

Summary: In this study, an endoplasmic reticulum (ER)-targeting near-infrared fluorescent probe ER-BnXPI was developed for monitoring CYP2J2 activity. The probe exhibited high selectivity and sensitivity towards CYP2J2 among various cytochrome P450 isoforms and effectively localized to the ER. Furthermore, the probe successfully imaged the variation behavior of CYP2J2 under the ER stress model in living cells and in different tumors, distinguishing tumor tissues from para-cancerous tissues. These findings suggest that ER-BnXPI could be a promising tool for studying the physiological function of CYP2J2 and may provide novel approaches for the diagnosis and therapy of CYP2J2-related vascular inflammation and cancer.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Responsive Fluorescent Coumarin-Cinnamic Acid Conjugates for α-Glucosidase Detection

Dong Luo et al.

Summary: In this study, two environmentally sensitive fluorescent probes, LD01 and LD02, were designed and synthesized for the detection of alpha-glucosidase. One of the probes showed a significant responsive emission enhancement upon binding to alpha-glucosidase. These newly designed probes can serve as simple yet efficient tools for evaluating the binding affinity of alpha-glucosidase to its inhibitors.

FRONTIERS IN CHEMISTRY (2022)

Article Chemistry, Analytical

Lumi-HOF@Tb as Probes for Multiple Ratiometric Fluorescence and Chemiluminescence Sensing of α-Glucosidase

Hai-Yan Li et al.

Summary: This study presents a synthesis strategy for luminescent hydrogen bonded organic frameworks (HOFs) for developing multifunctional optical sensors. The sensor demonstrates selective detection of enzyme activity and exhibits low detection limits.

ANALYTICAL CHEMISTRY (2022)

Review Clinical Neurology

Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management

Troels S. Jensen et al.

Summary: Peripheral neuropathy is a common complication of diabetes, with the most common type being distal symmetric polyneuropathy. Diagnosis of diabetic neuropathy remains challenging due to lack of a single established diagnostic standard, leading to a reliance on a hierarchical system combining symptoms, signs, and confirmatory tests for research purposes. Treatments for diabetic neuropathy focus on glycemic control and symptomatic management, with a need for large randomized clinical trials to identify the most effective interventions for improved patient outcomes.
Review Nanoscience & Nanotechnology

Progress of Nanotechnology in Diabetic Retinopathy Treatment

Yuxin Liu et al.

Summary: Diabetic retinopathy is a chronic complication of diabetes that can lead to vision problems or even blindness. Current treatments include laser photocoagulation, anti-VEGF drugs, and vitrectomy. Nanotechnology shows potential for innovative treatment approaches in DR.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Immunology

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

Liyan Mei et al.

Summary: This study investigated the changes in gut microbiome of RA patients treated with HQT or LEF, revealing significant differences in gut microbiota between RA patients and healthy controls. The clinical efficacy of the two treatments was similar, but the response trends of RA-related clinical indices differed between the two treatment groups.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biophysics

Confining copper nanoclusters on exfoliation-free 2D boehmite nanosheets: Fabrication of ultra-sensitive sensing platform for α-glucosidase activity monitoring and natural anti-diabetes drug screening

Sihan Chen et al.

Summary: This study developed a highly sensitive fluorescence sensing method for monitoring α-glucosidase activity and screening natural inhibitors, using Boe@GSH-CuNCs as fluorescence probes. The method achieved a detection limit lower than most other α-glucosidase activity assays and was able to identify potential anti-diabetes drugs from sources such as actinomycetes, peanut, sophora flower, celery, and orange.

BIOSENSORS & BIOELECTRONICS (2021)

Review Biochemistry & Molecular Biology

100 years of insulin: celebrating the past, present and future of diabetes therapy

Emily K. Sims et al.

Summary: This review highlights the scientific advancements in diabetes treatment and the milestones in insulin therapy, showcasing the evolution of insulin treatment and its impact on patients, as well as discussing future treatment and challenges to be addressed.

NATURE MEDICINE (2021)

Review Immunology

Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia

Xiaokang Jia et al.

Summary: Hyperlipidemia, characterized by excess fat or lipids in the bloodstream, is a high-risk factor for metabolic diseases. The gut microbiota and microbiota-related metabolites play crucial roles in the development and progression of hyperlipidemia. Various interventions targeted at the gut microbiota, such as prebiotics, probiotics, and fecal microbiota transplantation, have shown efficacy in treating hyperlipidemia.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

Anastasia Poznyak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

Role of gut microbiota in type 2 diabetes pathophysiology

Manoj Gurung et al.

EBIOMEDICINE (2020)

Review Endocrinology & Metabolism

Young-onset type 2 diabetes mellitus - implications for morbidity and mortality

Dianna J. Magliano et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Review Pharmacology & Pharmacy

Iminosugars: A host-targeted approach to combat Flaviviridae infections

Lisa Evans DeWald et al.

ANTIVIRAL RESEARCH (2020)

Review Endocrinology & Metabolism

Diabetes Insipidus An Update

Julie Refardt et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2020)

Article Endocrinology & Metabolism

Dietary lipids, gut microbiota and lipid metabolism

Marc Schoeler et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2019)

Article Endocrinology & Metabolism

Response of gut microbiota in type 2 diabetes to hypoglycemic agents

Fanghua Zhang et al.

ENDOCRINE (2019)

Article Biochemistry & Molecular Biology

Interaction of antidiabetic α-glucosidase inhibitors and gut bacteria α-glucosidase

Kemin Tan et al.

PROTEIN SCIENCE (2018)

Article Multidisciplinary Sciences

Temporal development of the gut microbiome in early childhood from the TEDDY study

Christopher J. Stewart et al.

NATURE (2018)

Review Chemistry, Multidisciplinary

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

Adam C. Sedgwick et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Endocrinology & Metabolism

Incidence of complications in young-onset diabetes: Comparing type 2 with type 1 (the young diab study)

Anandakumar Amutha et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2017)

Review Biochemistry & Molecular Biology

Amylolytic glycoside hydrolases

Stefan Janecek et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Medicine, General & Internal

Gut microbiota, obesity and diabetes

Elaine Patterson et al.

POSTGRADUATE MEDICAL JOURNAL (2016)

Review Plant Sciences

Natural Products for the Treatment of Type 2 Diabetes Mellitus

Jose Luis Ros et al.

PLANTA MEDICA (2015)

Article Multidisciplinary Sciences

Gut metagenome in European women with normal, impaired and diabetic glucose control

Fredrik H. Karlsson et al.

NATURE (2013)

Review Endocrinology & Metabolism

The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives

Lei Chen et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Article Biochemistry & Molecular Biology

Novel α-glucosidase from human gut microbiome: substrate specificities and their switch

Kemin Tan et al.

FASEB JOURNAL (2010)

Review Chemistry, Medicinal

Inhibitors Against Glycosidases as Medicines

Tetsuya Kajimoto et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)

Review Medicine, General & Internal

Lysosomal storage disease 2 - Pompe's disease

Ans T. van der Ploeg et al.

LANCET (2008)

Article Endocrinology & Metabolism

Diabetes and vascular disease

AJ Garber

DIABETES OBESITY & METABOLISM (2000)