4.2 Review

Medical Emergencies in Pulmonary Hypertension

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Article Critical Care Medicine

COVID-19 in Patients with Pulmonary Hypertension A National Prospective Cohort Study

David Montani et al.

Summary: COVID-19 in patients with precapillary PH was associated with a high in-hospital mortality. The typical risk factors for severe COVID-19 and severity of PH were associated with mortality in this population.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Thrombosis in hospitalized patients with viral respiratory infections versus COVID-19

Nathaniel R. Smilowitz et al.

Summary: The study compared the incidence of thrombosis in patients hospitalized with non-COVID-19 acute viral respiratory illnesses from 2012 to 2014 to those hospitalized with COVID-19 in a large health system in New York. It was found that the risk of thrombosis was lower in patients with viral respiratory illnesses compared to those with COVID-19. Further investigations into thrombosis mechanisms and risk reduction strategies in viral respiratory infections are needed.

AMERICAN HEART JOURNAL (2021)

Article Gastroenterology & Hepatology

Utility of Endoscopy in Hospitalized Patients with Gastrointestinal Hemorrhage and Pulmonary Hypertension

Amandeep Singh et al.

Summary: This study, based on the query of the National Inpatient Sample database, found that the prevalence of GIH in PH patients is increasing annually, with factors such as age and congestive heart failure being associated with its occurrence. Endoscopic interventions in PH patients with GIH help to reduce length of stay and in-hospital mortality.

DIGESTIVE DISEASES AND SCIENCES (2021)

Article Critical Care Medicine

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021

Laura Evans et al.

CRITICAL CARE MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Risk assessment in patients with pulmonary arterial hypertension in the era of COVID 19 pandemic and the telehealth revolution: State of the art review

Michael Wesley Milks et al.

Summary: During the COVID-19 pandemic, exploration of telehealth modalities for risk assessment and treatment titration in PAH patients has been undertaken, but further validation is still required.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

Article Anesthesiology

Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: a systematic review and expert consensus statement

Laura C. Price et al.

Summary: The 30-day mortality rate is higher in PH patients undergoing non-cardiac and non-obstetric surgery, with a strong correlation with acute right ventricular failure. Risk factors for mortality include procedure-specific and patient-related factors, particularly markers of PH severity. Individualized preoperative risk assessment and perioperative planning are crucial in reducing complications.

BRITISH JOURNAL OF ANAESTHESIA (2021)

Article Cardiac & Cardiovascular Systems

Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension

Tiberiu A. Pana et al.

Summary: Pulmonary hypertension was not significantly associated with in-hospital mortality after acute ischemic stroke, but was linked to prolonged hospitalization and adverse discharge status. Male patients with pulmonary hypertension had a higher risk of in-hospital death compared to female patients.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Review Cardiac & Cardiovascular Systems

Palliative care in pulmonary hypertension associated with congenital heart disease: systematic review and expert opinion

Andrew Constantine et al.

Summary: This study reviews the current literature on palliative care for PAH-CHD patients and highlights the lack of evidence-based clinical criteria for referral to palliative care or guidelines for managing advanced PAH-CHD patients. It emphasizes the importance of timely palliative care involvement and discussions on advance care planning to improve the quality of life and end-of-life care for this complex patient group.

ESC HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

Assessment of cardiac arrhythmias using long-term continuous monitoring in patients with pulmonary hypertension

Mads Orbaek Andersen et al.

Summary: This study found that arrhythmias were observed in 38% of contemporary patients with PH during long-term continuous monitoring, with the vast majority of episodes being short and self-limiting. SVTs were the most common type of arrhythmia.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

Review Medicine, General & Internal

Venous Thromboembolism in COVID-19 Compared to Non-COVID-19 Cohorts: A Systematic Review with Meta-Analysis

Antonella Tufano et al.

Summary: There is a difference in the risk of VTE between COVID-19 patients and non-COVID-19 patients, especially in the intensive care unit (ICU). This indicates the importance of prevention and early detection of thrombotic events in COVID-19 patients, particularly in ICU settings.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Liver abnormalities in pulmonary arterial hypertension

Nils P. Nickel et al.

Summary: PAH is a cardiopulmonary disease with high mortality, affecting multiple organ systems including the liver, histology, and systemic metabolism. Right heart failure can lead to congestive hepatopathy, impacting liver biochemistry, histology, and overall glucose and lipid metabolism. This article focuses on summarizing the consequences of congestive hepatopathy in PAH patients, with an emphasis on liver biochemistry, histology, and targeted therapy. Additionally, it discusses specific changes in glucose and lipid metabolism associated with PAH.

PULMONARY CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Association of right ventricular dysfunction and pulmonary hypertension with adverse 30-day outcomes in COVID-19 patients

Karan Wats et al.

Summary: This study found that right ventricular dysfunction, pulmonary hypertension, and tricuspid regurgitation were associated with increased odds of 30-day inpatient mortality in COVID-19 patients. Echocardiography plays a crucial role in evaluating the clinical outcomes of hospitalized COVID-19 patients.

PULMONARY CIRCULATION (2021)

Review Cardiac & Cardiovascular Systems

Epidemiology of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: identification of the most accurate estimates from a systematic literature review

Laurence Leber et al.

Summary: This systematic review critically assessed the incidence and prevalence estimates of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, highlighting a wide range of estimates in European adult populations. The most reliable estimates were obtained from recent national systematic registry data, aiding in resource allocation and detection rate improvements.

PULMONARY CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Patterns of thromboembolic pulmonary vascular disease in COVID-19

Yousef Shahin et al.

Summary: SARS-CoV-2 (COVID-19) is associated with increased thrombosis, leading to patterns of pulmonary vascular disease including classical acute pulmonary embolism and microvascular thrombosis evident in subsegmental perfusion defects.

PULMONARY CIRCULATION (2021)

Article Respiratory System

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

Fernando Holguin et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Article Cardiac & Cardiovascular Systems

Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure

Stephan Rosenkranz et al.

CIRCULATION (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Cardiac & Cardiovascular Systems

Primary cardiac hospitalizations in pulmonary arterial hypertension: Trends and outcomes from 2001 to 2014

Eileen M. Harder et al.

RESPIRATORY MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

Bo Li et al.

CLINICAL RESEARCH IN CARDIOLOGY (2020)

Review Medicine, General & Internal

Infective Endocarditis: A Contemporary Review

Scott A. Hubers et al.

MAYO CLINIC PROCEEDINGS (2020)

Review Respiratory System

Critical care of patients with pulmonary arterial hypertension

Shambhu Aryal et al.

CURRENT OPINION IN PULMONARY MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Eisenmenger syndrome: diagnosis, prognosis and clinical management

Alexandra Arvanitaki et al.

Letter Anesthesiology

Risks and outcomes of gastrointestinal endoscopy with anaesthesia in patients with pulmonary hypertension

Christopher Lai et al.

BRITISH JOURNAL OF ANAESTHESIA (2020)

Letter Cardiac & Cardiovascular Systems

Management of hospitalized patients with pulmonary arterial hypertension and COVID-19 infection

Sandeep Sahay et al.

PULMONARY CIRCULATION (2020)

Letter Cardiac & Cardiovascular Systems

COVID-19 and the pulmonary vasculature

Steeve Provencher et al.

PULMONARY CIRCULATION (2020)

Article Cardiac & Cardiovascular Systems

Efficacy of catheter ablation for atrial fibrillation in patients with congenital heart disease

Silvia Guarguagli et al.

EUROPACE (2019)

Review Cardiac & Cardiovascular Systems

The association between pulmonary hypertension and stroke: A systematic review and meta-analysis

Trushil G. Shah et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2019)

Article Neurosciences

Paradoxical Cerebral Embolism as Initial Manifestation of Chronic Thromboembolic Pulmonary Hypertension: A Case Report

Akira Machida et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Routine Postprocedure Chest Radiography Is Not Warranted After Right-Heart Catheterization

Christopher P. Centonze et al.

JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY (2019)

Article Respiratory System

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Respiratory System

Pulmonary hypertension in chronic lung disease and hypoxia

Steven D. Nathan et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Respiratory System

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

Anton Vonk Noordegraaf et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Cardiac & Cardiovascular Systems

Arrhythmias in adult patients with congenital heart disease and pulmonary arterial hypertension

Maria Drakopoulou et al.

Article Cardiac & Cardiovascular Systems

Usefulness of thrombosis and inflammation biomarkers in chronic thromboembolic pulmonary hypertension-sampling plasma and surgical specimens

Nika Skoro-Sajer et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2018)

Review Cardiac & Cardiovascular Systems

Levosimendan in pulmonary hypertension and right heart failure

Mona Sahlholdt Hansen et al.

PULMONARY CIRCULATION (2018)

Article Cardiac & Cardiovascular Systems

Atrial arrhythmias are associated with increased mortality in pulmonary arterial hypertension

Benjamin Smith et al.

PULMONARY CIRCULATION (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Bronchial artery embolization for the treatment of haemoptysis in pulmonary hypertension

Edoardo Rasciti et al.

RADIOLOGIA MEDICA (2017)

Article Respiratory System

Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

Jadwiga A. Wedzicha et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Article Cardiac & Cardiovascular Systems

Direct bilirubin: A new risk factor of adverse outcome in idiopathic pulmonary arterial hypertension

Xi-Qi Xu et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Incidence, predictors and outcomes of infective endocarditis in a contemporary adult congenital heart disease population

Benjamin Moore et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Left Main Coronary Artery Compression in Patients With Pulmonary Arterial Hypertension and Angina

Nazzareno Galie et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model

Georgina Palau-Caballero et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Respiratory System

BMPR2 mutation status influences bronchial vascular changes in pulmonary arterial hypertension

Maria-Rosa Ghigna et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

Article Cardiac & Cardiovascular Systems

Prevalence and distribution of focal triggers in persistent and long-standing persistent atrial fibrillation

Pasquale Santangeli et al.

HEART RHYTHM (2016)

Review Cardiac & Cardiovascular Systems

Remote Magnetic Navigation for Catheter Ablation in Patients With Congenital Heart Disease: A Review

Karine Roy et al.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Prognostic Relevance of Nonsustained Ventricular Tachycardia in Patients with Pulmonary Hypertension

Dirk Bandorski et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Review Critical Care Medicine

A global view of pulmonary hypertension

Marius M. Hoeper et al.

LANCET RESPIRATORY MEDICINE (2016)

Article Cardiac & Cardiovascular Systems

Supraventricular Arrhythmias in Patients With Pulmonary Arterial Hypertension

Margherita Cannillo et al.

AMERICAN JOURNAL OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

2015 ESC Guidelines for the management of infective endocarditis

Gilbert Habib et al.

EUROPEAN HEART JOURNAL (2015)

Article Respiratory System

Clinical relevance of right ventricular diastolic stiffness in pulmonary hypertension

Pia Trip et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Physiology

Exaggerated pulmonary vascular response to acute hypoxia in older men

George M. Balanos et al.

EXPERIMENTAL PHYSIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Right Heart and Pulmonary Vessels Structure and Function

Michele D'Alto et al.

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES (2015)

Article Cardiac & Cardiovascular Systems

Frequency and Prognostic Significance of Hemoptysis in Pediatric Pulmonary Arterial Hypertension

Marcus T. R. Roofthooft et al.

AMERICAN JOURNAL OF CARDIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Treatment of haemoptysis in pulmonary atresia with tranexamic acid

Matthew J. Devine et al.

CARDIOLOGY IN THE YOUNG (2013)

Article Cardiac & Cardiovascular Systems

Atrial flutter and fibrillation in patients with pulmonary hypertension

Karen M. Olsson et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

QTc prolongation is associated with impaired right ventricular function and predicts mortality in pulmonary hypertension

Jonathan D. Rich et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Cardiohepatic Interactions in Heart Failure An Overview and Clinical Implications

Marc D. Samsky et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Review Critical Care Medicine

Complications Leading to Sudden Cardiac Death in Pulmonary Arterial Hypertension

Eftychia A. Demerouti et al.

RESPIRATORY CARE (2013)

Review Critical Care Medicine

Management of Severe Pulmonary Arterial Hypertension

John Granton et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Cardiac & Cardiovascular Systems

Does tranexamic acid stop haemoptysis?

Christian Arvei Moen et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2013)

Article Medicine, General & Internal

Clinical implications of haemoptysis in patients with pulmonary arterial hypertension

Jose Cantu et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2012)

Article Cardiac & Cardiovascular Systems

Atrial Electrical and Structural Remodeling Associated with Longstanding Pulmonary Hypertension and Right Ventricular Hypertrophy in Humans

Caroline Medi et al.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2012)

Article Medicine, General & Internal

Clinical features of paediatric pulmonary hypertension: a registry study

Rolf M. F. Berger et al.

LANCET (2012)

Review Cardiac & Cardiovascular Systems

Arrhythmias in Pulmonary Arterial Hypertension

Archana Rajdev et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2012)

Review Respiratory System

Risk factors for chronic thromboembolic pulmonary hypertension

N. H. Kim et al.

EUROPEAN RESPIRATORY REVIEW (2012)

Article Cardiac & Cardiovascular Systems

Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension

Avi Shimony et al.

AMERICAN JOURNAL OF CARDIOLOGY (2011)

Review Critical Care Medicine

Intensive Care Unit Management of Patients with Severe Pulmonary Hypertension and Right Heart Failure

Marius M. Hoeper et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Letter Cardiac & Cardiovascular Systems

Clinical implications of supraventricular arrhythmias in patients with severe pulmonary arterial hypertension

Maria J. Ruiz-Cano et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2011)

Letter Cardiac & Cardiovascular Systems

Risk of Potentially Life-Threatening Thyroid Dysfunction Due to Amiodarone in Idiopathic Pulmonary Arterial Hypertension Patients

Elaine Soon et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

Article Respiratory System

Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension

B. Sztrymf et al.

EUROPEAN RESPIRATORY JOURNAL (2010)

Article Cardiac & Cardiovascular Systems

Abnormal Liver Function in Relation to Hemodynamic Profile in Heart Failure Patients

V. M. Van Deursen et al.

JOURNAL OF CARDIAC FAILURE (2010)

Review Cardiac & Cardiovascular Systems

Right Ventricular Heart Failure From Pulmonary Embolism: Key Distinctions From Chronic Pulmonary Hypertension

John A. Watts et al.

JOURNAL OF CARDIAC FAILURE (2010)

Review Respiratory System

Optimising the management of pulmonary arterial hypertension patients: emergency treatments

M. Delcroix et al.

EUROPEAN RESPIRATORY REVIEW (2010)

Review Medicine, General & Internal

Bleeding events in pulmonary arterial hypertension

C. F. Opitz et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Respiratory System

Risk factors for chronic thromboembolic pulmonary hypertension

D. Bonderman et al.

EUROPEAN RESPIRATORY JOURNAL (2009)

Article Cardiac & Cardiovascular Systems

Bronchial artery embolization for pulmonary arterial hypertension and recurrent hemoptysis?

Ricardo Petraco et al.

AMERICAN JOURNAL OF CARDIOLOGY (2008)

Article Critical Care Medicine

Brain-type natriuretic peptide levels in the prediction of adverse outcome in patients with pulmonary embolism - A systematic review and meta-analysis

Frederikus A. Klok et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

Editorial Material Medicine, General & Internal

Guidelines for the prevention of central venous catheter-related blood stream infections with prostanoid therapy for pulmonary arterial hypertension

A. K. Doran et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2008)

Article Cardiac & Cardiovascular Systems

Right coronary artery flow impairment in patients with pulmonary hypertension

Serge A. van Wolferen et al.

EUROPEAN HEART JOURNAL (2008)

Article Cardiac & Cardiovascular Systems

Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertension

Joern Tongers et al.

AMERICAN HEART JOURNAL (2007)

Review Medicine, General & Internal

Evaluation and management of the patient with pulmonary arterial hypertension

LJ Rubin et al.

ANNALS OF INTERNAL MEDICINE (2005)

Article Cardiac & Cardiovascular Systems

Now predictors of outcome in idiopathic pulmonary arterial hypertension

SM Kawut et al.

AMERICAN JOURNAL OF CARDIOLOGY (2005)

Article Cardiac & Cardiovascular Systems

Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism

S Kruger et al.

AMERICAN HEART JOURNAL (2004)

Article Cardiac & Cardiovascular Systems

Brain natriuretic peptide as a predictor of adverse outcome in patients with pulmonary embolism

M ten Wolde et al.

CIRCULATION (2003)

Article Critical Care Medicine

Desmopressin therapy for massive hemoptysis associated with severe leptospirosis

L Pea et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

Article Critical Care Medicine

Outcome after cardiopulmonary resuscitation in patients with pulmonary arterial hypertension

MM Hoeper et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

Article Cardiac & Cardiovascular Systems

Right ventricular ischemia in patients with primary pulmonary hypertension

A Gómez et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2001)

Article Cardiac & Cardiovascular Systems

Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism

E Giannitsis et al.

CIRCULATION (2000)