Broadly neutralizing antibodies: The next thing to treat children with HIV?

Article Immunology

Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA

N. Archin et al.

Summary: The International Workshop on HIV Persistence during Therapy provides a platform for researchers to share the latest findings on viral reservoirs and cure. With over 400 attendees, the Tenth Workshop included sessions on viral persistence, therapeutic approaches, and updates on research advancements. The conference focused on abstract-driven presentations, including community representatives showcasing messaging strategies for cure research literacy.

JOURNAL OF VIRUS ERADICATION (2023)

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Article Cell Biology

Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana

Roger L. Shapiro et al.

Summary: This study demonstrates that broadly neutralizing antibodies (bNAbs) may serve as an alternative treatment for controlling HIV-1 replication and have immunotherapeutic effects against HIV-1 reservoirs. A prospective clinical trial on children who had received small-molecule ART treatment before 7 days of age revealed that 44% of the children maintained low HIV-1 RNA levels during 24 weeks of bNAb-only treatment, while 56% experienced detectable viremia.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Article Biochemistry & Molecular Biology

Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial

Joseph P. Casazza et al.

Summary: This study demonstrates that using adeno-associated viral vectors can durably produce biologically active broadly neutralizing antibodies in vivo, providing valuable new tools for fighting infectious diseases.

NATURE MEDICINE (2022)

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Review Immunology

An exploration of how broadly neutralizing antibodies might induce HIV remission: the 'vaccinal' effect

Timothy Tipoe et al.

Summary: This review explores the mechanisms of action of broadly neutralizing antibodies (bNAbs) and summarizes the evidence supporting their immunomodulatory properties. The authors propose the concept of a 'vaccinal effect' where bNAbs lead to sustained viral remission by blocking viral entry and through immune-modulatory mechanisms. The potent antiviral efficacy of bNAb therapy is emerging, but the ability of bNAbs to induce sustained viral suppression below therapeutic levels remains controversial.

CURRENT OPINION IN HIV AND AIDS (2022)

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Review Virology

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

Priya Khetan et al.

Summary: This review provides a broad overview of key interventions aimed at reducing and controlling the latent reservoir in adults with HIV-1 and pediatric populations. The focus is primarily on early treatment in combination with broadly neutralizing antibodies. The review also summarizes current assays for measuring HIV-1 reservoirs and discusses their feasibility and considerations for studies involving children.

VIRUSES-BASEL (2022)

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Review Immunology

Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection

Seemal F. Awan et al.

Summary: This article reviews the use of anti-HIV-1 broadly neutralizing antibodies (bNAbs) for the prevention and treatment of HIV-1 infection. Multiple bNAbs have shown promising results in clinical trials. The article also discusses the current landscape of HIV-1 bNAbs in clinical development and the strategies employed to improve their breadth, potency, serum half-life, effector function, and administration.

CURRENT OPINION IN HIV AND AIDS (2022)

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Article Immunology

Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants

Coleen K. Cunningham et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Cell Biology

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Pilar Garcia-Broncano et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Broadly neutralizing antibodies: The next thing to treat children with HIV?

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