Altered generation pattern of reactive oxygen species triggering DNA and plasma membrane damages to human liver cells treated with arsenite

Review Environmental Sciences

Metabolic characteristics related to the hazardous effects of environmental arsenic on humans: A metabolomic review

Haoqi Guo et al.

Summary: Arsenic is a toxic metalloid commonly found in the environment, which damages multiple organs or tissues in the body. Metabolomics studies can provide insights into the hazardous effects and mechanisms of arsenic exposure in humans.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Engineering, Environmental

Assessing the potential value of Rosa Roxburghii Tratt in arsenic-induced liver damage based on elemental imbalance and oxidative damage

Yuyan Xu et al.

Summary: This study demonstrates that Rosa roxburghii Tratt (RRT) has the potential to alleviate coal-burning arsenic-induced liver damage by regulating elemental metabolic disorders and liver oxidation and antioxidant balance. The findings suggest that RRT could be an effective intervention strategy for arsenic-induced liver damage. Further research is warranted to explore the mechanisms behind these protective effects.

ENVIRONMENTAL GEOCHEMISTRY AND HEALTH (2021)

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Review Pharmacology & Pharmacy

Arsenic: A Global Environmental Challenge

Qiao Yi Chen et al.

Summary: Arsenic, a naturally occurring metalloid that can be metabolized inside human body, is pervasive in nature and anthropogenic sources, leading to human exposure to this toxic and carcinogenic element. Approximately 200 million people worldwide are exposed to potentially toxic levels of arsenic, prompting substantial research and mitigation efforts to combat this extensive public health issue.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

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Article Environmental Sciences

Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Jagdish Gopal Paithankar et al.

Summary: The oxidative stress induced by heavy metals and its connection with different signaling pathways are complex, which may lead to a variety of health issues. Exposure to heavy metals/metalloids such as Arsenic, Chromium, Cadmium, and Lead can trigger oxidative stress and subsequently cellular and organismal responses, involving regulation of multiple signaling pathways.

CHEMOSPHERE (2021)

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Review Biochemistry & Molecular Biology

On the relevance of hydroxyl radical to purine DNA damage

Chryssostomos Chatgilialoglu et al.

Summary: This review focuses on the impact of hydroxyl radicals on DNA damage, particularly in the context of purine DNA lesions. Different methodologies for quantifying purine lesions are discussed, with an emphasis on the distinct mechanisms of lesion formation. Recent findings on the quantification of specific purine lesions in various biological specimens are presented, shedding light on their biological significance.

FREE RADICAL RESEARCH (2021)

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Article Environmental Sciences

Toxicity of selected airborne nitrophenols on eukaryotic cell membrane models

Marta Majewska et al.

Summary: This study investigates the cytotoxic effects of a nitrophenol mixture on cell membranes, using in vitro cellular models and a simulated eukaryotic-like cell membrane to understand the mechanism of this impact.

CHEMOSPHERE (2021)

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Article Environmental Sciences

Association between arsenic exposure, DNA damage, and urological cancers incidence: A long-term follow-up study of residents in an arseniasis endemic area of northeastern Taiwan

Tsung-Lin Tsai et al.

Summary: This study investigated the association between arsenic exposure, DNA damage, and the incidence of bladder and kidney cancers, finding a significant increase in DNA damage associated with arsenic exposure. The combined effects of high cumulative arsenic exposure from artesian well-water and advanced DNA damage predicted an increased risk of bladder cancer.

CHEMOSPHERE (2021)

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Review Environmental Sciences

Arsenic exposure from groundwater: environmental contamination, human health effects, and sustainable solutions

Elida Cristina Monteiro De Oliveira et al.

Summary: Arsenic is naturally occurring but can also contaminate groundwater due to mining, agricultural, and industrial processes. Human exposure to arsenic from contaminated water can lead to acute toxicity and chronic effects, including skin lesions and cancer. Strategies to diminish arsenic in water include physicochemical treatment systems, bioremediation using cyanobacteria and algae, and nanotechnology applications.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2021)

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Article Agriculture, Multidisciplinary

Metallothionein Attenuated Arsenic-Induced Cytotoxicity: The Underlying Mechanism Reflected by Metabolomics and Lipidomics

Zihe Qi et al.

Summary: Arsenic ions (As3+) are recognized as a hazard to human health, but metallothionein (MT) rich in cysteine can alleviate As3+-induced cytotoxicity. As3+ disrupts phospholipids metabolism, induces cell membrane damage, and perturbs energy and amino acid metabolism. MT rescues As3+-induced metabolic disorder and suppresses reactive oxygen species accumulation by forming As3+-MT complex.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Engineering, Environmental

Non-targeted metabolomics of multiple human cells revealing differential toxic effects of perfluorooctanoic acid

Ruijia Zhang et al.

Summary: In this study, non-targeted metabolomics was used to evaluate the differential toxicity of perfluorooctanoic acid (PFOA) on multiple human cell lines. It was found that PFOA influenced metabolism pathways and inflammation factor levels in different cell lines, indicating a potential mechanism for its toxic effects.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Environmental Sciences

13C isotope-based metabolic flux analysis revealing cellular landscape of glucose metabolism in human liver cells exposed to perfluorooctanoic acid

Ruijia Zhang et al.

Summary: The study found that perfluorooctanoic acid (PFOA) primarily affects glucose metabolism by altering the tricarboxylic acid (TCA) cycle rather than glycolysis, leading to impaired mitochondrial respiratory function. Metabolic flux analysis (MFA) is a promising tool for investigating the toxicity mechanisms of contaminants associated with glucose metabolism.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Arsenic or/and antimony induced mitophagy and apoptosis associated with metabolic abnormalities and oxidative stress in the liver of mice

Gaolong Zhong et al.

Summary: The study demonstrated that co-exposure to arsenic and antimony can result in oxidative damage and mitochondrial injury in the liver, leading to abnormal liver energy metabolism and lipid metabolism disorder. Mitophagy and apoptosis play important roles in the mechanisms of arsenic/antimony cytotoxicity to mouse livers.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Oncology

Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity

Orazio Cantoni et al.

Summary: Arsenite, an important carcinogen and toxic compound, exerts its harmful effects mainly by affecting the production of mitochondrial ROS. The interaction between endoplasmic reticulum and mitochondria, as well as the potential regulation by the ER stress response, may play a crucial role in mediating these effects.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Role of Reactive Oxygen Species in Arsenic Toxicity

Yuxin Hu et al.

BIOMOLECULES (2020)

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Article Engineering, Environmental

Fetal bovine serum attenuating perfluorooctanoic acid-inducing toxicity to multiple human cell lines via albumin binding

Ruijia Zhang et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Environmental Sciences

ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling

Chunyan Liu et al.

ENVIRONMENTAL TOXICOLOGY (2020)

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Review Medicine, Research & Experimental

Pharmacological strategies to lower crosstalk between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and mitochondria

Nirmala Koju et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Public, Environmental & Occupational Health

Comprehensive analysis of the metabolomic characteristics on the health lesions induced by chronic arsenic exposure: A metabolomics study

Chaonan Jia et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2019)

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Article Environmental Sciences

Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Panida Navasumrit et al.

ENVIRONMENTAL HEALTH (2019)

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Article Environmental Sciences

Environmentally relevant concentrations of arsenite induces developmental toxicity and oxidative responses in the early life stage of zebrafish

Hong-Jie Sun et al.

ENVIRONMENTAL POLLUTION (2019)

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Article Biotechnology & Applied Microbiology

Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic

Cesar Rivas-Santiago et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Review Environmental Sciences

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

Paul B. Tchounwou et al.

ENVIRONMENTAL TOXICOLOGY (2019)

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Article Multidisciplinary Sciences

Molecular dynamic simulations of oxidized skin lipid bilayer and permeability of reactive oxygen species

Dharmendra KumarYadav et al.

SCIENTIFIC REPORTS (2019)

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Review Environmental Sciences

Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte

Huan Xu et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2018)

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Article Toxicology

Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 beta cells

E. N. Dover et al.

ARCHIVES OF TOXICOLOGY (2018)

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Article Biochemistry & Molecular Biology

Distribution of arsenic and oxidative stress in mice after rice ingestion

Juliana Maria Oliveira Souza et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2017)

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Article Toxicology

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

Rance Nault et al.

TOXICOLOGICAL SCIENCES (2016)

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Article Toxicology

Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells

Huan Xu et al.

TOXICOLOGICAL SCIENCES (2016)

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Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and Associated ROS

Hafiz Maher Ali Zeeshan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Pharmacology & Pharmacy

The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells

Andrea Guidarelli et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

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Review Environmental Sciences

Arsenic contamination, consequences and remediation techniques: A review

Rachana Singh et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2015)

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Article Biochemistry & Molecular Biology

Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity

Xiaoxue Wang et al.

METALLOMICS (2015)

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Review Biochemistry & Molecular Biology

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Joe Dan Dunn et al.

REDOX BIOLOGY (2015)

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Article Biochemical Research Methods

Metabolomic study in plasma, liver and kidney of mice exposed to inorganic arsenic based on mass spectrometry

M. A. Garcia-Sevillano et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2014)

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Article Engineering, Environmental

Urinary Metabolomics Revealed Arsenic Internal Dose-Related Metabolic Alterations: A Proof-of-Concept Study in a Chinese Male Cohort

Jie Zhang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

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Article Toxicology

NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity

Ying-Na Li et al.

TOXICOLOGY LETTERS (2014)

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Article Biochemistry & Molecular Biology

Membrane phospholipid synthesis and endoplasmic reticulum function

Paolo Fagone et al.

JOURNAL OF LIPID RESEARCH (2009)

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Letter Oncology

Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity

V Mathews et al.

LEUKEMIA (2006)

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Altered generation pattern of reactive oxygen species triggering DNA and plasma membrane damages to human liver cells treated with arsenite

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