4.4 Article

CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis

Pontus Plaven-Sigray et al.

Summary: Pharmacological and genetic evidence suggest a role for the dopamine D2-receptor in schizophrenia pathophysiology. This study used PET imaging to compare D2-R density in thalamus between first-episode psychosis patients and healthy controls, finding lower binding in patients and suggesting a potential disturbance of thalamocortical connectivity. Additionally, diffusion tensor imaging revealed lower fractional anisotropy values in the inferior thalamic radiation in patients compared to controls.

MOLECULAR PSYCHIATRY (2022)

Review Neurosciences

A New Look on an Old Issue: Comprehensive Review of Neurotransmitter Studies in Cerebrospinal Fluid of Patients with Schizophrenia and Antipsychotic Effect on Monoamine's Metabolism

Matthieu Gasnier et al.

Summary: This comprehensive review explores the role of neurotransmitter metabolism in schizophrenia, discussing the anomalies of CSF monoamines, their correlation with clinical features, and the influence of antipsychotic treatment. Findings suggest that low HVA levels are associated with more positive symptoms and a poorer outcome. Additional studies are needed to further understand the potential of CSF monoamines as biomarkers for disease severity and treatment response, considering confounding factors such as antipsychotic prescription, inflammatory markers, and folate metabolism.

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE (2021)

Article Psychiatry

Dopamine and glutamate in schizophrenia: biology, symptoms and treatment

Robert A. McCutcheon et al.

WORLD PSYCHIATRY (2020)

Review Neurosciences

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms

Robert A. McCutcheon et al.

TRENDS IN NEUROSCIENCES (2019)

Article Biochemistry & Molecular Biology

CSF GABA is reduced in first-episode psychosis and associates to symptom severity

F. Orhan et al.

MOLECULAR PSYCHIATRY (2018)

Review Psychiatry

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

Oliver D. Howes et al.

ARCHIVES OF GENERAL PSYCHIATRY (2012)

Article Psychiatry

The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity

Keith H. Nuechterlein et al.

AMERICAN JOURNAL OF PSYCHIATRY (2008)

Article Pharmacology & Pharmacy

In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function

S Jordan et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2004)

Article Pharmacology & Pharmacy

GABA(B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo

S Erhardt et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2002)

Review Pharmacology & Pharmacy

Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence

A Carlsson et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)

Article Biochemistry & Molecular Biology

Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons

S Erhardt et al.

AMINO ACIDS (2001)