Mechanochemical synthesis of organohalogen compounds: a synthetic chemist's view

Data on the mechanochemical synthesis of halogen-containing organic compounds published mainly over the past 10 years are summarized and critically analyzed. The established views about the methods of activation of mechanochemical halogenation reactions are discussed. The mechanochemical fluorination, chlorination, bromination and iodination reactions of organic compounds are considered. Particular attention is paid to reaction mechanisms, selectivity problem and consideration of the mechanochemical approach as a promising trend of green chemistry. The review is devoted to applications of mechanochemistry in organic synthesis, while the fundamentals of mechanochemistry are beyond the scope of this publication.

Automated summary

This review summarizes and critically analyzes the data on the mechanochemical synthesis of halogen-containing organic compounds published mainly over the past 10 years. The established views about the methods of activation of mechanochemical halogenation reactions are discussed. The review considers the mechanochemical fluorination, chlorination, bromination, and iodination reactions of organic compounds. Special attention is given to reaction mechanisms, selectivity problems, and the consideration of mechanochemical approach as a promising trend of green chemistry.