☆ 4.3 Review

Ruthenium complexes for breast cancer therapy

REVIEWS IN INORGANIC CHEMISTRY (2023)

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Metal organic frameworks (MOFS) as non-viral carriers for DNA and RNA delivery: a review

Gabriela Soriano-Giles et al.

Summary: Metal-Organic Frameworks (MOFs) are crystalline materials with large surface area and high porosity, which make them versatile in various fields of application. MOFs can function as hosts for molecules of different sizes and chemical properties. This article discusses the existing approaches for incorporating biomolecules into MOFs and explores the challenges and strategies for designing MOFs for effective gene delivery.

REVIEWS IN INORGANIC CHEMISTRY (2023)

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Article Chemistry, Physical

Synthesis, molecular docking and anticancer potential of azolium based salts and their silver complexes: DNA/BSA interaction studies and cell cycle analysis

Rizwan Ashraf et al.

Summary: In this study, three binuclear molten salts and their silver complexes were synthesized and characterized. It was found that these compounds exhibited significant anticancer activity and interacted with DNA and BSA. Furthermore, the role of hydrophobicity in the cytotoxicity of the complexes was revealed.

JOURNAL OF MOLECULAR LIQUIDS (2023)

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Article Chemistry, Inorganic & Nuclear

O -Halogen-substituted arene linked selenium- N -heterocyclic carbene compounds induce significant cytotoxicity: Crystal structures and molecular docking studies

Khizar Hayat et al.

Summary: Stable N-heterocyclic Carbene (NHC) Sigma-donor ligands, N-arylated benzimidazolium salts 1-2, were synthesized in a simple, facile, and high-yielding method. Selenium adducts 3-4 were also synthesized using elemental selenium as a reactant. The synthesized compounds were characterized using spectroscopic methods and their anticancer activity was evaluated against different cancer cell lines. The docking analysis revealed potential interactions between the compounds and cancer-related proteins.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Evaluation of Ruthenium(II) N-Heterocyclic Carbene Complexes as Enzymatic Inhibitory Agents with Antioxidant, Antimicrobial, Antiparasitical and Antiproliferative Activity

Ibrahim S. S. Al Nasr et al.

Summary: A series of RuCl2(p-cymene)(NHC) complexes were synthesized and their structures were determined. These complexes exhibited potent enzyme inhibitory, antioxidant, antimicrobial, anticancer, and antiparasitic properties. Among them, complex 3d showed the highest inhibitory activity against AchE, excellent antimicrobial activity, and promising cytotoxic and antiparasitic activities. Further research on its mode of action and in vivo evaluation is recommended.

MOLECULES (2023)

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Article Chemistry, Inorganic & Nuclear

Mechanistic, Computational Study of Alkene-Diazene Heterofunctional Cross-Metathesis Catalyzed by Ruthenium Complexes

Magdalena Jawiczuk et al.

Summary: Density functional theory calculations were employed to investigate the potential of 17 different ruthenium catalysts in the cross-metathesis reaction between diazenes and alkenes. The results indicate that certain well-designed catalysts can facilitate this transformation. The first-generation Hoveyda-Grubbs and indenylidene catalysts are predicted to have the highest reaction rates and lower energy barriers than other catalysts, suggesting the feasibility of this process at mild temperatures. In addition, competing reactions involving the association of an imine molecule with the active ruthenium complex were also analyzed to gain a better understanding of the still unclear mechanism of azo metathesis.

ORGANOMETALLICS (2023)

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Review Chemistry, Inorganic & Nuclear

Metal-Organic Frameworks as bio- and heterogeneous catalyst supports for biodiesel production

Yetzin Rodriguez Mejia et al.

Summary: This review focuses on the advantages of using various MOFs structures as supports for heterogeneous catalysts and biocatalysts in the eco-friendly biodiesel production process. The characteristics of these materials and their fabrication synthesis are briefly discussed, and recommendations based on the limiting factors are provided.

REVIEWS IN INORGANIC CHEMISTRY (2023)

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Review Chemistry, Inorganic & Nuclear

Detection of different chemical moieties in aqueous media by luminescent Europium as sensor

Komal Bashir et al.

Summary: In this review, detectors synthesized by combining different ligands with luminescent europium complexes were discussed for the separation of metals and chemical moieties in water. These detectors showed high sensitivity, selectivity, and low detection limits, making them suitable for sensing chemical moieties and trace metals. The luminescent changes of these detectors were observable with the naked eye.

REVIEWS IN INORGANIC CHEMISTRY (2023)

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Article Spectroscopy

Surface-enhanced Raman spectral characterization of antifungal activity of selenium and zinc based organometallic compounds

Ali Raza et al.

Summary: In this study, surface-enhanced Raman spectroscopy (SERS) was used to analyze the biochemical changes associated with the antifungal activities of selenium and zinc organometallic complexes. The SERS spectral changes helped to understand the mechanism of action of these antifungal agents. Statistical tools like principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA) were used to analyze the SERS spectra and differentiate different groups of spectra.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2023)

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Review Chemistry, Inorganic & Nuclear

The use of metal-organic frameworks as heterogeneous catalysts

Viktoria Larina et al.

Summary: This article provides an overview of available research studies on MOFs as catalysts, summarizing studies on modified surfaces of magnetic iron oxide nanoparticles, MOFs with precious metals (palladium, platinum, silver), zirconium, hafnium, copper, alkaline earth metals, and lanthanides. It also describes the catalytic activity studies of micro- and mesoporous MOF structures.

REVIEWS IN INORGANIC CHEMISTRY (2023)

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Review Medicine, Research & Experimental

Half-Sandwich Ruthenium Arene Complexes Bearing Clinically Approved Drugs as Ligands: The Importance of Metal-Drug Synergism in Metallodrug Design

Chezhiyan Sumithaa et al.

Summary: A novel strategy in metallodrug discovery is incorporating clinically approved drugs into metal complexes as ligands. This approach has been used to re-purpose drugs, prepare organometallic complexes, overcome drug resistance, and design promising alternatives to current metal-based drugs. The combination of organoruthenium moiety and clinical drug in a single molecule has been shown to enhance pharmacological activity and reduce toxicity. This review summarizes recent reports on rationally designed ruthenium complexes containing FDA-approved drugs, focusing on coordination mode, kinetics, mechanism, and structure-activity relationship. It provides insights for future developments in ruthenium-based metallopharmaceuticals.

MOLECULAR PHARMACEUTICS (2023)

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Article Chemistry, Multidisciplinary

Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts

Amna Kamal et al.

Summary: Alkyl-substituted azolium salts and their Se-N-heterocyclic carbene adducts were synthesized and characterized. The Se-N-heterocyclic carbene adducts showed stability at room temperature in both air and moisture. In vitro studies revealed that most of the selenium N-heterocyclic carbene adducts exhibited activity against Bacillus subtilis.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN (2023)

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Review Chemistry, Multidisciplinary

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Lisa Gourdon et al.

Summary: Photodynamic therapy and photoactivated chemotherapy are therapeutic techniques that utilize photosensitizers and light to control drug activation. Exploration of first-row transition metal complexes as photosensitizers has shown promising results.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Chemistry, Inorganic & Nuclear

Latest developments in metal complexes as anticancer agents

Renata Paprocka et al.

Summary: This review examines important research findings on the activity and toxicity of metal-based cancer drug candidates from 2018 to 2020. New multi-action platinum(IV) prodrugs and other metal complexes are designed to overcome cisplatin-resistant cancer cells. The review also discusses the use of new metal complexes for photodynamic therapy and the conjugation of complexes with conventional drugs, showcasing their new mechanisms of action.

COORDINATION CHEMISTRY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy

Zhi-Yuan Li et al.

Summary: This review introduces the potential of metal complexes in cancer immunotherapy and summarizes recent discoveries on the immune effects of platinum-based compounds. It also outlines the latest research on metal complexes for cancer immunotherapy, focusing on platinum, ruthenium, iridium, rhenium, and copper complexes. Finally, it discusses research perspectives and unresolved problems in the application of metallo-anticancer agents in cancer immunotherapy.

CHEMISTRY-AN ASIAN JOURNAL (2022)

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Review Chemistry, Inorganic & Nuclear

In-vitro anticancer profile of recent ruthenium complexes against liver cancer

Khurram Shahzad et al.

Summary: Ruthenium complexes are considered as promising alternatives to platinum-based cancer drugs due to their acceptable toxicity level, selectivity, variant oxidation states, and ability to treat platinum-resistant cancer cells. This study demonstrates the in-vitro anticancer activity of several ruthenium complexes against hepatocellular carcinoma, with some complexes showing superior activity compared to positive controls. The structure-activity relationship analysis provides insights for the design and synthesis of new ruthenium anticancer drugs.

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Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments

Brondwyn S. McGhie et al.

Summary: Cancer is responsible for over 9 million deaths worldwide each year. Current treatment options have low success rates, especially for late-stage cancers. Researchers globally are continuously searching for alternative treatment options. This study focuses on innovations in inorganic anticancer therapies with photoactive and luminescent properties. Transition metals offer advantages in both chemotherapeutics and luminescence. The study explores the effects of structural changes on the properties and the use of inherent luminescent properties for monitoring cellular localization in photodynamic therapy.

BIOMEDICINES (2022)

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Review Chemistry, Multidisciplinary

Metal complex-based liposomes: Applications and prospects in cancer diagnostics and therapeutics

Zhaomeng Wang et al.

Summary: Metal complex-based liposomes have attracted increasing interest in cancer diagnostics and therapeutics. They offer the potential to enhance therapeutic efficacy and reduce side effects. This review provides an overview of the latest advances in metal complex-based liposomal delivery systems, including encapsulation techniques, applications, and advantages.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Targeting of the intracellular redox balance by metal complexes towards anticancer therapy

Maria Isabel Murillo et al.

Summary: The development of cancers is closely related to alterations in essential redox processes. Transition metal derivatives have shown promise as alternative treatments to platinum-based drugs due to their favorable redox properties and different routes of action. This review discusses recent research on how transition metal complexes have been designed to impact redox processes, aiming for more effective and specific cancer treatments.

FRONTIERS IN CHEMISTRY (2022)

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Review Chemistry, Multidisciplinary

Ruthenium Complexes as Potential Cancer Cell Growth Inhibitors for Targeted Chemotherapy

Snehlata Katheria

Summary: This review provides an overview of the research progress on targeted chemotherapy using ruthenium complexes, including the mechanisms of action on various organelles, DNA, and specific enzymes. It offers valuable information for the design and creation of new anticancer ruthenium complexes research.

CHEMISTRYSELECT (2022)

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Review Chemistry, Medicinal

Potential of Gold Candidates against Human Colon Cancer

Mahvish Abbasi et al.

Summary: Development of novel metallodrugs, especially gold complexes, has shown significant potential in modern medicinal chemistry and cancer therapy. Gold(I) species interact with DNA, while Au(III) compounds with square-planner geometries are promising sources for anti-tumor agents. The review aims to discuss the important applications of gold products in human colon cancer treatment and the complex interaction between gold and the human body.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Target based chemotherapeutic advancement of ruthenium complexes

Pragti et al.

Summary: This review focuses on recent research on organometallic ruthenium complexes for targeted chemotherapy in cancer treatment, highlighting their target specificity and mechanisms of action. It also discusses structure-activity relationships, imaging technologies, and the use of nanocarriers to expand the scope of metal-based anticancer research.

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Article Chemistry, Physical

Blue-to-red light triggered nitric oxide release in cytotoxic/cytostatic ruthenium nitrosyl complexes bearing biomimetic ligands

Elena D. Stolyarova et al.

Summary: Two nitrosyl complexes were synthesized and characterized, showing light-induced NO release and cytotoxicity against breast adenocarcinoma cells. Photolysis and electrochemical techniques were used to investigate the activation of NO, and DFT calculations revealed possible charge transfers responsible for the activation. The study opens up possibilities for designing and synthesizing new compounds with photo-sensitive and cytotoxic properties.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2021)

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Review Chemistry, Inorganic & Nuclear

Recent advances in the synthesis of (99mTechnetium) based radio-pharmaceuticals

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REVIEWS IN INORGANIC CHEMISTRY (2021)

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Metal complexes of β-carboline: Advances in anticancer therapeutics

Yusuf Oloruntoyin Ayipo et al.

Summary: This review highlights the recent development of metal complexes of beta C derivatives in anticancer therapeutic designs, focusing on their multi-mechanistic anticancer effects and toxicity to normal cells. These complexes demonstrate high cytotoxicity against various cancer cells, including cisplatin-resistant types, while showing low toxicity to normal cells, making them potential therapeutic agents.

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Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents

I. A. Shutkov et al.

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PLOS ONE (2021)

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Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos

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Rationally Designed Ruthenium Complexes for Breast Cancer Therapy

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Synthesis, physicochemical characterization and biological properties of two novel Cu(II) complexes based on natural products curcumin and quercetin

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Breast Cancer Chemotherapeutic Options: A General Overview on the Preclinical Validation of a Multi-Target Ruthenium(III) Complex Lodged in Nucleolipid Nanosystems

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Automated design and optimization of multitarget schizophrenia drug candidates by deep learning

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review

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Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives

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Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

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Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications

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Biological properties of metal complexes of curcumin

Abolfazl Shakeri et al.

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NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

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Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates?

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The stepwise photodamage of organelles by two-photon luminescent ruthenium(ii) photosensitizers

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Article Biochemistry & Molecular Biology

Nucleus-enriched Ruthenium Polypyridine Complex Acts as a Potent Inhibitor to Suppress Triple-negative Breast Cancer Metastasis In vivo

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Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

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Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

Enzo Alessio

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2017)

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Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives

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A Review of Ruthenium Complexes Activities on Breast Cancer Cells

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A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer

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Metal complexes in cancer therapy - an update from drug design perspective

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The development of ruthenium(II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

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Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space

Nicholas A. Meanwell

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Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

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Inhibition of cancer cell growth by ruthenium complexes

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Studying Z-DNA and B- to Z-DNA transitions using a cytosine analogue FRET-pair

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Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10] phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells

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Mitochondrial Ca2+ uptake controls actin cytoskeleton dynamics during cell migration

Julien Prudent et al.

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Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs

Ekaterina Schreiber-Brynzak et al.

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Article Chemistry, Medicinal

Water-Soluble Ruthenium(II) Complexes with Chiral 442,3-Dihydroxypropyl)-formamide Oxoaporphine (FOA): In Vitro and in Vivo Anticancer Activity by Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Induction of Tumor Cell Apoptosis

Zhen-Feng Chen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

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Article Chemistry, Physical

Ruthenium complexes of ferrocene mannich bases: DNA/BSA interactions and cytotoxicity against A549 cell line

Pulipaka Ramadevi et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2015)

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Article Chemistry, Multidisciplinary

Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities Against 2D and 3D Cancer Models

Huaiyi Huang et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

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Article Oncology

Breast Cancer: Conventional Diagnosis and Treatment Modalities and Recent Patents and Technologies

Mohamed I. Nounou et al.

BREAST CANCER-BASIC AND CLINICAL RESEARCH (2015)

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Article Oncology

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models

Yihao Li et al.

BREAST CANCER RESEARCH (2015)

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Article Oncology

Cellular responses of BRCA1-defective and triple-negative breast cancer cells and in vitro BRCA1 interactions induced by metallo-intercalator ruthenium(II) complexes containing chloro-substituted phenylazopyridine

Tidarat Nhukeaw et al.

BMC CANCER (2014)

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Article Chemistry, Medicinal

Ruthenium(II) complexes as apoptosis inducers by stabilizing c-myc G-quadruplex DNA

Zhao Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Medicinal

In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer

Malgorzata Frik et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

Modulation of Activity of Known Cytotoxic Ruthenium(III) Compound (KP418) with Hampered Transmembrane Transport in Electrochemotherapy In Vitro and In Vivo

Rosana Hudej et al.

JOURNAL OF MEMBRANE BIOLOGY (2014)

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NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

Robert Trondl et al.

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Investigation of aromatase inhibitory activity of metal complexes of β-hydroxyquinoline and uracil derivatives

Veda Prachayasittikul et al.

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The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(II) asymmetric complexes

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METALLOMICS (2013)

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The binding and transport of alternative metals by transferrin

John B. Vincent et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

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Article Chemistry, Multidisciplinary

Ruthenium(II/III)-Based Compounds with Encouraging Antiproliferative Activity against Non-small-Cell Lung Cancer

Eszter M. Nagy et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

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Article Chemistry, Medicinal

New Ruthenium(II)-Letrozole Complexes as Anticancer Therapeutics

Annie Castonguay et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

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Bis(tridentate) Ruthenium-Terpyridine Complexes Featuring Microsecond Excited-State Lifetimes

Douglas G. Brown et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

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The DNA damage response and cancer therapy

Christopher J. Lord et al.

NATURE (2012)

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Article Chemistry, Inorganic & Nuclear

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

Alberta Bergamo et al.

DALTON TRANSACTIONS (2011)

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Meeting Abstract Oncology

A phase I dose-escalation study of NKP-1339 in patients with advanced solid tumors refractory to treatment.

N. R. Dickson et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

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Review Chemistry, Inorganic & Nuclear

Arene ruthenium complexes as anticancer agents

Georg Suess-Fink

DALTON TRANSACTIONS (2010)

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Article Biochemistry & Molecular Biology

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

Petra Heffeter et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2010)

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Article Chemistry, Medicinal

Nuclear Permeable Ruthenium(II)β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

Caiping Tan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

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Article Chemistry, Multidisciplinary

Isolated Seven-Coordinate Ru(IV) Dimer Complex with [HOHOH]- Bridging Ligand as an Intermediate for Catalytic Water Oxidation

Lele Duan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

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Article Multidisciplinary Sciences

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

Samantha Lin Chiou Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Chemistry, Physical

Behavior of H2 chemisorption on Ru/TiO2 surface and its application in evaluation of Ru particle sizes compared with TEM and XRD analyses

Xiongfei Shen et al.

APPLIED CATALYSIS A-GENERAL (2008)

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Review Biochemistry & Molecular Biology

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

Christian G. Hartinger et al.

CHEMISTRY & BIODIVERSITY (2008)

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Article Chemistry, Inorganic & Nuclear

Mixed-ligand Copper(II)-phenolate complexes: Effect of coligand on enhanced DNA and protein binding, DNA cleavage, and anticancer activity

Venugopal Rajendiran et al.

INORGANIC CHEMISTRY (2007)

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Review Biochemistry & Molecular Biology

Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development

Robert D. Bruno et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

From bench to bedside -: preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)

Christian G. Hartinger et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2006)

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Article Chemistry, Inorganic & Nuclear

Metal-based antitumour drugs in the post genomic era

PJ Dyson et al.

DALTON TRANSACTIONS (2006)

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Review Biochemistry & Molecular Biology

Ruthenium complexes as anticancer agents

I Kostova

CURRENT MEDICINAL CHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

Synthesis, characterization, DNA-binding and photocleavage of complexes [Ru(phen)2(6-OH-dppz)]2+ and [Ru(phen)2(6-NO2-dppz)]2+

XW Liu et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2005)

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Review Oncology

Taxanes as first-line therapy for advanced non-small cell lung cancer: A systematic review and practice guideline

Q Chu et al.

LUNG CANCER (2005)

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Article Biochemistry & Molecular Biology

Syntheses and DNA-binding studies of two ruthenium(II) complexes containing one ancillary ligand of bpy or phen:: [Ru(bpy)(pp[2,3]p)2](ClO4)2 and [Ru(phen)(pp[2,3]p)2](ClO4)2

BY Wu et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2005)

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Article Oncology

Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells

S Kapitza et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2005)

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Article Chemistry, Inorganic & Nuclear

Synthesis and structural characterization of Cu(I) and that Ni(II) complexes that contain the bis[2-(diphenylphosphino)phenyl]ether ligand. Novel emission properties for the Cu(I) species

SM Kuang et al.

INORGANIC CHEMISTRY (2002)

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Article Pharmacology & Pharmacy

Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara®) in breast cancer patients

CU Pfister et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2001)

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Article Chemistry, Inorganic & Nuclear

A Cu(I) coordination polymer employing a nonsteroidal aromatase inhibitor letrozole as a building block

RX Yuan et al.

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS (2001)

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