4.5 Review

The Long-Term Outcome of Children Conceived Through Assisted Reproductive Technology

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Article Psychiatry

Long-term Follow-up of Psychiatric Disorders in Children and Adolescents Conceived by Assisted Reproductive Techniques in Sweden

Chen Wang et al.

Summary: Adolescents and young adults conceived with assisted reproductive techniques (ARTs) do not have a higher risk of poor psychiatric health compared to the general population, except for a slightly elevated risk of obsessive-compulsive disorder which may be explained by differences in parental characteristics.

JAMA PSYCHIATRY (2022)

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Growth in children conceived by ART

Maria C. Magnus et al.

Summary: Children conceived by ART are shorter and lighter at birth, but experience more rapid growth and surpass naturally conceived children in height and weight by age 3. However, by age 17, there are no significant differences in height and weight between ART and naturally conceived children.

HUMAN REPRODUCTION (2021)

Article Obstetrics & Gynecology

Cognitive achievements in school-age children born following assisted reproductive technology treatments: A prospective study

Adel Farhi et al.

Summary: The study found that children born following assisted reproductive technology treatments showed similar cognitive function, visual-motor ability, attention, and verbal skills compared to spontaneously conceived children. This indicates that there were no significant differences in the developmental outcomes between the two groups during early school years.

EARLY HUMAN DEVELOPMENT (2021)

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Association of Childhood Fat Mass and Weight With Adult-Onset Type 2 Diabetes in Denmark

Mohammed T. Hudda et al.

Summary: This population-based cohort study in Denmark found that childhood fat mass (FM) had stronger associations with adult type 2 diabetes (T2D) risk than childhood weight, independent of height.

JAMA NETWORK OPEN (2021)

Review Pediatrics

Association of assisted reproductive technology with autism spectrum disorder in the offspring: an updated systematic review and meta-analysis

Maria T. Andreadou et al.

Summary: This study conducted a meta-analysis on the correlation between assisted reproductive technology (ART) conception and the risk of autism spectrum disorder (ASD) in offspring, finding a positive correlation between ART and ASD while no significant association was observed in singletons. Future high-quality prospective studies with larger sample sizes are needed to further validate these findings.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Early Embryo Exposure to Assisted Reproductive Manipulation Induced Subtle Changes in Liver Epigenetics with No Apparent Negative Health Consequences in Rabbit

Ximo Garcia-Dominguez et al.

Summary: The study found changes related to lipid metabolism and DNA methylation in offspring of assisted reproductive technology (ART), but these differences did not seem to significantly affect general health status.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pediatrics

Assisted Reproductive Techniques, ADHD, and School Performance

Chen Wang et al.

Summary: The study found that children conceived with assisted reproductive techniques (ART) had a lower risk of ADHD and performed better in school compared to other children. Differences in parental characteristics explained and even reversed associations, with no disadvantage seen when comparing children of couples with known infertility.

PEDIATRICS (2021)

Article Multidisciplinary Sciences

Comparison of the performances of survival analysis regression models for analysis of conception modes and risk of type-1 diabetes among 1985-2015 Swedish birth cohort

Adeniyi Francis Fagbamigbe et al.

Summary: This study aimed to examine the risk of type-1 diabetes using different survival analysis models, finding that different modes of conception have varying impacts on the risk of type-1 diabetes in children, with a higher risk associated with frozen-thawed embryo transfers.

PLOS ONE (2021)

Article Medicine, General & Internal

Cardiovascular disease, obesity, and type 2 diabetes in children born after assisted reproductive technology: A population-based cohort study

Emma Norrman et al.

Summary: A large population-based cohort study in the Nordic countries found that children born after assisted reproductive technology (ART) did not have a significantly different risk of cardiovascular disease or type 2 diabetes compared to children born after spontaneous conception (SC), but had a slightly higher risk of obesity.

PLOS MEDICINE (2021)

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The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

Asa Magnusson et al.

Summary: Studies have found an association between high birth weight or large for gestational age babies and increased risks for certain childhood malignancies, breast cancer, psychiatric disorders, childhood hypertension, and type 1 and 2 diabetes. Despite these risks, the effects seem moderate and should be considered in decisions regarding assisted reproductive technology cycles.

FRONTIERS IN PEDIATRICS (2021)

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Assisted reproductive technology in Japan: A summary report for 2018 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology

Osamu Ishihara et al.

Summary: In 2018, the total number of ART treatment cycles and live births in Japan saw an increase from the previous year. Over 80% of cases involved single embryo transfer (SET), and there was a continuous shift from using fresh embryos to frozen-thawed embryos for embryo transfer compared to previous years.

REPRODUCTIVE MEDICINE AND BIOLOGY (2021)

Review Clinical Neurology

Risk of neurodevelopmental disorders in children born from different ART treatments: a systematic review and meta-analysis

Tono Djuwantono et al.

JOURNAL OF NEURODEVELOPMENTAL DISORDERS (2020)

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ART in Europe, 2015: results generated from European registries by ESHRE

C. De Geyter et al.

HUMAN REPRODUCTION OPEN (2020)

Review Obstetrics & Gynecology

Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis

B. Bay et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2019)

Article Obstetrics & Gynecology

Risk of cancer in children and young adults conceived by assisted reproductive technology

Mandy Spaan et al.

HUMAN REPRODUCTION (2019)

Article Obstetrics & Gynecology

Health of adults aged 22 to 35 years conceived by assisted reproductive technology

Jane Halliday et al.

FERTILITY AND STERILITY (2019)

Article Pediatrics

Association of In Vitro Fertilization With Childhood Cancer in the United States

Logan G. Spector et al.

JAMA PEDIATRICS (2019)

Review Developmental Biology

Assessing the epigenetic risks of assisted reproductive technologies: a way forward

Federica Zacchini et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2019)

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Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence

Theo A. Meister et al.

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Health and functioning of adolescents conceived by assisted reproductive technology

Eyal Fruchter et al.

FERTILITY AND STERILITY (2017)

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In Vitro fertilization and adverse obstetric and perinatal outcomes

Chantae S. Sullivan-Pyke et al.

SEMINARS IN PERINATOLOGY (2017)

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The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

M. Chen et al.

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DOHaD (Developmental Origins of Health and Disease) and Birth Cohort Research

Hideoki Fukuoka

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2015)

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Subfertility and assisted reproduction techniques are associated with poorer cardiometabolic profiles in childhood

Martina Pontesilli et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2015)

Article Endocrinology & Metabolism

Altered Glucose Metabolism in Mouse and Humans Conceived by IVF

Miaoxin Chen et al.

DIABETES (2014)

Article Pediatrics

Asthma in Swedish children conceived by in vitro fertilisation

Bengt Kallen et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2013)

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Assisted Reproductive Technologies Are Associated With Cardiovascular Remodeling In Utero That Persists Postnatally

Brenda Valenzuela-Alcaraz et al.

CIRCULATION (2013)

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Low birth weight: is it related to assisted reproductive technology or underlying infertility?

Laxmi A. Kondapalli et al.

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Fertility treatment and childhood cancer risk: a systematic meta-analysis

Marie Hargreave et al.

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Cancer Risk among Children Born after Assisted Conception

Carrie L. Williams et al.

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APPLICATIONS OF NEXT-GENERATION SEQUENCING De novo mutations in human genetic disease

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Reproductive Technologies and the Risk of Birth Defects

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Long-Term Outcomes in Children Born after Assisted Conception

Esther Eisenberg

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Does in vitro Fertilisation Increase Type 2 Diabetes and Cardiovascular Risk?

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Assisted reproductive technology and risk for autism spectrum disorder

Ditza A. Zachor et al.

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Autism Spectrum Disorders and Epigenetics

Daria Grafodatskaya et al.

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Growth of children conceived by IVF and ICSI up to 12 years of age

Emre Basatemur et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2010)

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Imprinting disorders and assisted reproductive technology

Somjate Manipalviratn et al.

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Epidemiology of Pervasive Developmental Disorders

Eric Fombonne

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Pubertal development in children and adolescents born after IVF and spontaneous conception

Manon Ceelen et al.

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Cardiometabolic differences in children born after in vitro fertilization:: Follow-up study

Manon Ceelen et al.

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Follow-up of Children Born after ART

E. Basatemur et al.

PLACENTA (2008)

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Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study

Marianne E. Doornbos et al.

HUMAN REPRODUCTION (2007)

Article Endocrinology & Metabolism

In vitro fertilization improves childhood growth and metabolism

Harriet L. Miles et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

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Do children born after assisted conception have less risk of developing infantile autism?

Rikke Damkjaer Maimburg et al.

HUMAN REPRODUCTION (2007)

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Population-based Swedish studies of outcomes after in vitro fertilisation

Karl-Gosta Nygren et al.

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Health of children born as a result of in vitro fertilization

Reija Klemetti et al.

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In vitro fertilization in Sweden:: child morbidity including cancer risk

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Imprinting diseases and IVF: Danish National IVF cohort study

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