Gut microbiota alterations in schizophrenia might be related to stress exposure: Findings from the machine learning analysis

Specific mechanisms underlying gut microbiota alterations in schizophrenia remain unknown. We aimed to compare gut microbiota between patients with schizophrenia and controls, taking into consideration exposure stress across lifespan, dietary habits, metabolic parameters and clinical manifestation. A total of 142 participants, including 89 patients with schizophrenia and 52 controls, were recruited. Gut microbiota were analyzed using the 16 S rRNA sequencing. Additionally, biochemical parameters related to glucose homeostasis, lipid profile and inflammation were assessed. Increased abundance of Lactobacillus and Limosilactobacillus as well as decreased abundance of Faecalibacterium and Paraprevotella were found in patients with schizophrenia. The machine learning analysis demonstrated that between-group differences in gut microbiota were associated with psychosocial stress (a history of childhood trauma, greater cumulative exposure to stress across lifespan and higher level of perceived stress), poor nutrition (lower consumption of vegetables and fish products), lipid profile alterations (lower levels of high-density lipoproteins) and cognitive impairment (worse performance of attention). Our findings indicate that gut microbiota alterations in patients with schizophrenia, including increased abundance of lactic acid bacteria (Lactobacillus and Limosilactobacillus) and decreased abundance of bacteria producing short-chain fatty acids (Faecalibacterium and Paraprevotella) might be associated with exposure to stress, poor dietary habits, lipid profile alterations and cognitive impairment.

Automated summary

This study aimed to compare gut microbiota between patients with schizophrenia and controls, taking into consideration factors such as exposure stress, dietary habits, metabolic parameters, and clinical manifestation. The results showed increased abundance of Lactobacillus and Limosilactobacillus and decreased abundance of Faecalibacterium and Paraprevotella in patients with schizophrenia. Machine learning analysis revealed that these gut microbiota differences were associated with factors such as psychosocial stress, poor nutrition, lipid profile alterations, and cognitive impairment.