☆ 4.7 Article

Identification of drug repurposing candidates for the treatment of anxiety: A genetic approach

PSYCHIATRY RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

添加到收藏夹

Article Multidisciplinary Sciences

FinnGen provides genetic insights from a well-phenotyped isolated population

Mitja Kurki et al.

Summary: Population isolates, like those in Finland, provide valuable insights for genetic research due to the concentration of deleterious alleles in low-frequency variants. FinnGen aims to study the genome and health data of 500,000 Finnish individuals, enabling the identification of new associations and the exploration of their implications for common diseases. The study identified 30 new associations and 2,733 genome-wide significant associations, highlighting the power of bottlenecked populations in uncovering disease biology.

NATURE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Ying Zhou et al.

Summary: Drug discovery relies not only on knowledge of drugs and targets, but also on understanding comparative agents and targets. This study introduces a major update to the Therapeutic Target Database, providing valuable data on poor binders, non-binders, prodrug-drug pairs, co-targets, and drug-like properties, as well as additional features for advanced search and cross-links to target structures. The database is accessible without login requirement at: https://idrblab.org/ttd/.

NUCLEIC ACIDS RESEARCH (2022)

添加到收藏夹

Review Medicine, General & Internal

Antibiotics and mental health: The good, the bad and the ugly

Katherine Dinan et al.

Summary: Antibiotics have both positive and negative impacts on mental health through the brain-gut-microbiota axis. Gut microbes influence brain function through various mechanisms, such as the vagus nerve and the production of certain substances. Some antibiotics have shown antidepressant activity, while others may decrease gut microbial diversity and increase the risk of depression. It is important to consider the off-target effects of antibiotics on mental health during clinical practice and efforts should be made to minimize these effects in the development of new antibiotics.

JOURNAL OF INTERNAL MEDICINE (2022)

添加到收藏夹

News Item Biotechnology & Applied Microbiology

REGULATORY WATCH Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs

David Ochoa et al.

NATURE REVIEWS DRUG DISCOVERY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development

Peng Ren et al.

Summary: Depression is a common neuropsychiatric illness that has been worsened by the COVID-19 pandemic. The discovery of new compounds, such as sigma-1 receptor ligands, as potential treatments for depression is of great importance. Understanding the role of sigma-1 receptors in regulating CNS diseases and maintaining homeostasis is crucial for developing fast-acting drugs for depression.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Genetics & Heredity

Ten challenges for clinical translation in psychiatric genetics

Eske M. Derks et al.

Summary: This Perspective highlights ten challenges in translating psychiatric genetic findings into clinical practice, including the detection of robust and generalizable genetic risk factors, improved definition and assessment of psychopathology, and achieving better clinical indicators. Recent advancements in the field will enhance the explanatory and predictive power of genetic data, ultimately contributing to improved management and treatment of patients with psychiatric disorders.

NATURE GENETICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts

Sharon L. Freshour et al.

Summary: The Drug-Gene Interaction Database (DGIdb) is a web resource that provides information on drug-gene interactions and druggable genes. DGIdb 4.0 is the latest major version release, featuring integration with crowdsourced efforts, addition of new sources, and updates to the data.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

Christopher N. Foley et al.

Summary: Genome-wide association studies have identified thousands of genomic regions affecting complex diseases. The authors propose HyPrColoc, an efficient Bayesian clustering algorithm, to detect colocalized traits from large numbers of traits. This method can be used to identify causal genes and shared genetic aetiology across traits.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Psychology, Biological

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

Jackson G. Thorp et al.

Summary: Using factor analysis and genomic structural equation modelling, this study investigated the genetic factor structure underlying depression, anxiety, and neuroticism and conducted genome-wide association analyses to identify a high genetic correlation between depressive and anxiety symptoms. Validation in a cohort of approximately 1.9 million individuals confirmed the reliability of the results, revealing shared and trait-specific genetic associations between depression and anxiety.

NATURE HUMAN BEHAVIOUR (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

An Evidence-Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

Michelle Whirl-Carrillo et al.

Summary: Clinical annotations in PharmGKB summarize the association between variant-drug pairs and are assigned a level of evidence. To ensure consistency and transparency, a scoring system has been developed to automate LOE assignment. This system improves the quality and reliability of clinical annotations.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Review Genetics & Heredity

Advancing the use of genome-wide association studies for drug repurposing

William R. Reay et al.

Summary: Genome-wide association studies have provided important biological insights into complex diseases, offering opportunities for drug repurposing. Leveraging common variant genetics through approaches such as single-loci mapping to drug targets, transcriptome-wide association studies, gene-set association, causal inference by Mendelian randomization, and polygenic scoring, researchers aim to identify new treatment options more efficiently.

NATURE REVIEWS GENETICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A major role for common genetic variation in anxiety disorders

Kirstin L. Purves et al.

MOLECULAR PSYCHIATRY (2020)

添加到收藏夹

Article Psychiatry

Reproducible Genetic Risk Loci for Anxiety: Results From similar to 200,000 Participants in the Million Veteran Program

Daniel F. Levey et al.

AMERICAN JOURNAL OF PSYCHIATRY (2020)

添加到收藏夹

Article Genetics & Heredity

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

Na Cai et al.

NATURE GENETICS (2020)

添加到收藏夹

Review Psychiatry

Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options

Amir Garakani et al.

FRONTIERS IN PSYCHIATRY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases

Na Ye et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Psychiatry

Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period

Gilliard Lach et al.

TRANSLATIONAL PSYCHIATRY (2020)

添加到收藏夹

Article Cell Biology

Structural Basis of the Diversity of Adrenergic Receptors

Lu Qu et al.

CELL REPORTS (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

DrugBank 5.0: a major update to the DrugBank database for 2018

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

Marion Soto et al.

MOLECULAR PSYCHIATRY (2018)

添加到收藏夹

Article Pediatrics

Extended Release Guanfacine in Pediatric Anxiety Disorders: A Pilot, Randomized, Placebo-Controlled Trial

Jeffrey R. Strawn et al.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2017)

添加到收藏夹

Article Oncology

Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress

Li-Li Ji et al.

MOLECULAR MEDICINE REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Functional mapping and annotation of genetic associations with FUMA

Kyoko Watanabe et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian et al.

CELL (2017)

添加到收藏夹

Article Medicine, General & Internal

Gut microbiota's effect on mental health: The gut-brain axis

Megan Clapp et al.

CLINICS AND PRACTICE (2017)

添加到收藏夹

Article Behavioral Sciences

Activation of Sigma-1 receptor ameliorates anxiety-like behavior and cognitive impairments in a rat model of post-traumatic stress disorder

Li-Li Ji et al.

BEHAVIOURAL BRAIN RESEARCH (2016)

添加到收藏夹

Article Genetics & Heredity

Integrative approaches for large-scale transcriptome-wide association studies

Alexander Gusev et al.

NATURE GENETICS (2016)

添加到收藏夹

Article Neurosciences

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer et al.

NATURE NEUROSCIENCE (2016)

添加到收藏夹

Article Psychology, Clinical

Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis: A Nested Case-Control Study

Ido Lurie et al.

JOURNAL OF CLINICAL PSYCHIATRY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

添加到收藏夹

Article Neurosciences

The PsychENCODE project

Schahram Akbarian et al.

NATURE NEUROSCIENCE (2015)

添加到收藏夹

Article Biochemical Research Methods

MAGMA: Generalized Gene-Set Analysis of GWAS Data

Christiaan A. de Leeuw et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

Olivier Delaneau et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Article Genetics & Heredity

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

Claudia Giambartolomei et al.

PLOS GENETICS (2014)

添加到收藏夹

Editorial Material Genetics & Heredity

The Genotype-Tissue Expression (GTEx) project

John Lonsdale et al.

NATURE GENETICS (2013)

添加到收藏夹

Review Psychology, Clinical

Global prevalence of anxiety disorders: a systematic review and meta-regression

A. J. Baxter et al.

PSYCHOLOGICAL MEDICINE (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

Development of a large-scale de-identified DNA biobank to enable personalized medicine

D. M. Roden et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)

添加到收藏夹

Article Neurosciences

Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent:: Relevance to its anti depressant/anxiolytic-like profile

Y. Claustre et al.

NEUROSCIENCE (2008)

添加到收藏夹

Article Behavioral Sciences

Confirmation of antidepressant potential of the selective β3 adrenoceptor agonist amibegron in an animal model of depression

David H. Overstreet et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2008)

添加到收藏夹

Article Neurosciences

Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder

Eduardo Dunayevich et al.

NEUROPSYCHOPHARMACOLOGY (2008)

添加到收藏夹

Article Neurosciences

Stimulation of the β3-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders

Jeanne Stemmelin et al.

NEUROPSYCHOPHARMACOLOGY (2008)

添加到收藏夹

Article Medicine, General & Internal

A brief measure for assessing generalized anxiety disorder -: The GAD-7

Robert L. Spitzer et al.

ARCHIVES OF INTERNAL MEDICINE (2006)

添加到收藏夹

Review Biochemistry & Molecular Biology

Treatment-resistant anxiety disorders

A. Bystritsky

MOLECULAR PSYCHIATRY (2006)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

CJ Swanson et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

添加到收藏夹

Article Behavioral Sciences

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

DD Schoepp et al.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2003)

添加到收藏夹

Review Psychiatry

A review and meta-analysis of the genetic epidemiology of anxiety disorders

JM Hettema et al.

AMERICAN JOURNAL OF PSYCHIATRY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.