4.7 Article

Exercise elevates serum brain-derived neurotrophic factor in partially remitted depression

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PSYCHIATRY RESEARCH
卷 326, 期 -, 页码 -

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ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2023.115283

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Physical activity; Blood serum; Biomarkers

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This study aimed to investigate the effect of exercise on brain-derived neurotrophic factor (BDNF) levels in patients with major depressive disorder (MDD). The results showed that strenuous activity significantly increased serum BDNF levels in MDD patients.
Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515).

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