☆ 4.5 Review

Immune capture and protein profiling of small extracellular vesicles from human plasma

PROTEOMICS (2023)

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Review Spectroscopy

A guide to mass spectrometric analysis of extracellular vesicle proteins for biomarker discovery

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Summary: Exosomes, as small extracellular vesicles, play a crucial role in living organisms for processes like cell proliferation and intercellular communication. They have been extensively studied as biomarkers for various diseases. This review focuses on the enrichment methods, characterization techniques, and recent trends in exosome analysis using mass spectrometry-based approaches for biomarker discovery.

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Review Spectroscopy

Enriching extracellular vesicles for mass spectrometry

Jordan B. Burton et al.

Summary: Extracellular vesicles, particularly exosomes, have great potential as biomarkers for health and cell activity status. Effective enrichment of exosomes is essential for analysis and high throughput approaches are achievable.

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Article Oncology

A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer

Keiko Kasahara et al.

Summary: This study performed a large-scale targeted proteomics analysis of plasma extracellular vesicles to identify novel subtypes of colorectal cancer (CRC) and important biomarker proteins associated with these subtypes. Liquid biopsy assessment with targeted proteomics analysis was proposed to be crucial for predicting CRC prognosis.

CANCER MEDICINE (2023)

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Article Biochemistry & Molecular Biology

L1CAM immunocapture generates a unique extracellular vesicle population with a reproducible miRNA fingerprint

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Summary: MicroRNAs(miRNAs) have potential as diagnostic and prognostic biomarkers, but inconsistencies across studies have hindered their clinical application. Differences in miRNAs associated with specific diseases and regulation direction reflect the heterogeneity of pathologies or different protocols. This study aimed to determine if a unique extracellular vesicle fraction could improve the reproducibility of miRNA fingerprint diagnostic of ALS.

RNA BIOLOGY (2023)

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Review Biotechnology & Applied Microbiology

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Jiaci Chen et al.

Summary: Exosomes, as nano-sized extracellular vesicles, play an important role in cell-specific material transfer and have potential applications in prognosis, diagnosis, and treatment. Existing exosomal separation techniques have limitations in terms of complexity, time consumption, and low purity, highlighting the need for efficient and simple isolation methods. Microfluidic chips have emerged as a promising technology for exosome isolation. A comprehensive review covering exosomal properties, conventional technologies, emerging isolation strategies, and large-scale production of engineered exosomes is essential.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Current status and outlook of advances in exosome isolation

Wen-Zhao Liu et al.

Summary: This review analyzes the progress in exosomal isolation strategies and proposes views on the development prospects of various exosomal isolation techniques.

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Article Cell Biology

Proteomic and Metabolomic Profiles of T Cell-Derived Exosomes Isolated from Human Plasma

Aneta Zebrowska et al.

Summary: This study demonstrates the isolation of CD3(+) exosomes from human plasma using immune capture and their subsequent molecular profiling using proteomics and metabolomics. The CD3(+) exosomes were enriched with proteins and metabolites that reflect the molecular features of T lymphocytes.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Characteristics of Exosomes and the Vascular Landscape Regulate Exosome Sequestration by Peripheral Tissues and Brain

William A. Banks et al.

Summary: Exosomes mediate intercellular communication and their tissue sequestration levels vary among different tissues. The sequestration is regulated by both exosomes and tissues, and can be influenced by WGA and inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle- and exosome-like populations of KIT-containing extracellular vesicles

Annika Pfeiffer et al.

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Evaluation of Exosome Proteins by on-Bead Flow Cytometry

Marie-Nicole Theodoraki et al.

Summary: Exosomes, also known as small extracellular vesicles or sEV, are a system of intercellular communication. Quantification of exosome cargo using on-bead flow cytometry is essential for understanding their role in information transfer and human disease. This method is standardized for protein detection and quantitation in exosomes isolated from cell supernatants or plasma of cancer patients, providing valuable insights into the surface and intravesicular content of these vesicles.

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Proteomic Signature of Extracellular Vesicles for Lung Cancer Recognition

Svetlana E. Novikova et al.

Summary: Targeted mass spectrometry was used to analyze the proteins in vesicles derived from lung cancer cell lines and detect them in plasma samples from lung cancer patients and healthy volunteers. TLN1, TUBA4A, and HSPA8 were identified as the most diagnostically potent markers for distinguishing between lung adenocarcinoma and squamous cell carcinoma histological types.

MOLECULES (2021)

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Article Cell Biology

Proteomic profile of melanoma cell-derived small extracellular vesicles in patients' plasma: a potential correlate of melanoma progression

Monika Pietrowska et al.

Summary: This study demonstrates that molecular profiling of sEV isolated from plasma of cancer patients can distinguish tumor-derived sEV from non-malignant cell-derived sEV and identify potential prognostic biomarkers for melanoma.

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Article Oncology

Quantitative Proteomic Analysis of Plasma Exosomes to Identify the Candidate Biomarker of Imatinib Resistance in Chronic Myeloid Leukemia Patients

Mei-Yong Li et al.

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Tumor-Derived Exosomes (TEX) and Their Role in Immuno-Oncology

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Summary: Extracellular vesicles, especially tumor-derived exosomes, play a crucial role in cancer by mediating interactions between tumor cells and immune cells. The molecular and functional profiles of these EVs vary in cancer patients, impacting immune cell functions and disease progression. Potential biomarkers and monitors of immune competence in cancer patients can be identified through the analysis of these EVs.

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Article Biochemical Research Methods

L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma

Maia Norman et al.

Summary: L1CAM, previously thought to be a marker for neuron-derived extracellular vesicles, has been shown to not be associated with extracellular vesicles in human plasma or cerebrospinal fluid, and is therefore not recommended for use in NDEV isolation protocols.

NATURE METHODS (2021)

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Review Biochemical Research Methods

Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation

Ernesto S. Nakayasu et al.

Summary: Mass-spectrometry-based proteomics is a powerful method for discovering disease biomarkers, but critical steps in study design are often neglected. These steps include cohort selection, evaluation of statistical power, sample blinding and randomization, and quality control.

NATURE PROTOCOLS (2021)

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The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment

Hanyu Zhang et al.

Summary: Stromal cells in the gastric tumor microenvironment play a supportive role in tumor growth, while exosomes serve as crucial transporters of substances for cell-cell communication during tumor-stroma crosstalk. Therefore, exosomes present new biomarkers for gastric cancer diagnosis, prognosis, and potential treatment approaches.

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Evaluation of Colon-Specific Plasma Nanovesicles as New Markers of Colorectal Cancer

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Summary: Developing new and efficient approaches for the early diagnosis of colorectal cancer is a critical issue. Circulating extracellular nanovesicles derived from colon epithelium cells may serve as promising cancer markers. Increasing the number of ENVs carrying colon-specific markers could potentially be used as a diagnostic criterion for colorectal cancer.

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Formation of a protein corona on the surface of extracellular vesicles in blood plasma

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Summary: This study found that a protein corona is formed around EVs in blood plasma, with shared EV corona proteins identified. These results help explain the commonly reported plasma protein 'contamination' of EV preparations and offer a new perspective for EV research.

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Cancer Liquid Biopsy Using Integrated Microfluidic Exosome Analysis Platforms

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Sequential phosphoproteomics and N-glycoproteomics of plasma-derived extracellular vesicles

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Article Multidisciplinary Sciences

Melanoma cell-derived exosomes in plasma of melanoma patients suppress functions of immune effector cells

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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Ayuko Hoshino et al.

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A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

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Review Biochemistry & Molecular Biology

Immunocapture-based ELISA to characterize and quantify exosomes in both cell culture supernatants and body fluids

Mariantonia Logozzi et al.

EXTRACELLULAR VESICLES (2020)

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Article Oncology

Extracellular vesicles from young women's breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Kimberly R. Jordan et al.

BREAST CANCER RESEARCH (2020)

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Review Oncology

Exosomes as a Multicomponent Biomarker Platform in Cancer

Valerie S. LeBleu et al.

TRENDS IN CANCER (2020)

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Article Cell Biology

Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized isolation

Rossella Crescitelli et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Biochemical Research Methods

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

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Review Biochemical Research Methods

Protein Composition Reflects Extracellular Vesicle Heterogeneity

Tatyana Vagner et al.

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High sensitivity detection of extracellular vesicles immunecaptured from urine by conventional flow cytometry

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Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

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Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway

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Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

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Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers

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Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment

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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

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Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma

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Phosphoproteins in extracellular vesicles as candidate markers for breast cancer

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles

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Article Biochemical Research Methods

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