期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 125, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2023.110740
关键词
Cytokines; Psychiatric disorders; Meta-analysis; Network meta-analysis
Immune dysregulated cytokine production plays a crucial role in mental diseases. The pattern of cytokine alterations varies across different psychiatric disorders. A network impact analysis was conducted to evaluate the clinical impact of cytokine levels in schizophrenia, major depressive disorder, bipolar disorder, panic disorder, post-traumatic stress disorder, and obsessive-compulsive disorder. The results showed significantly increased levels of proinflammatory cytokines, hsCRP/CRP, and interleukin 6 (IL-6) in patients with psychiatric disorders compared to controls. IL-6 did not show significant differences between disorders according to the network meta-analysis. Interleukin 10 (IL-10) was significantly increased in patients with bipolar disorder compared to major depressive disorder, and interleukin-1 beta (IL-1 beta) was significantly increased in major depressive disorder compared to bipolar disorder. The levels of interleukin 8 (IL-8) varied among these psychiatric disorders based on the network meta-analysis. Overall, abnormal cytokine levels were found in psychiatric disorders, and some cytokines, especially IL-8, showed differential characteristics, suggesting their potential as biomarkers for general and differential diagnosis.
Immune dysregulated cytokine production is involved in mental diseases. However, the results are inconsistent and the pattern of cytokine alterations has not been compared across disorders. We performed a network impact analysis of cytokine levels for different psychiatric disorders including schizophrenia, major depressive disorder, bipolar disorder, panic disorder, post-traumatic stress disorder and obsessive compressive disorder to evaluate their clinical impact across conditions. Studies were identified by searching the electronic databases up to 31/ 05/2022. A total of eight cytokines, together with (high-sensitivity) C-reactive proteins (hsCRP/CRP) were included in the network meta-analysis. The levels of proinflammatory cytokines, hsCRP/CRP and interleukin 6 (IL-6) were significantly increased in patients with psychiatric disorders when compared to controls. IL-6 showed no significant difference among comparisons between disorders according to the network meta-analysis. Inter-leukin 10 (IL-10) is significantly increased in patients with bipolar disorder compared to major depressive dis -order. Further, the level of interleukin-1 beta (IL-1 beta) was significantly increased in major depressive disorder as compared to bipolar disorder. The level of interleukin 8 (IL-8) varied among these psychiatric disorders based on the network meta-analysis result. Overall, abnormal cytokine levels were found in psychiatric disorders, and some of the cytokines displayed differential characteristics in these disorders, especially IL-8, pointing to a role as potential biomarkers for general and differential diagnosis.
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