期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 290, 期 2009, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2023.1284
关键词
SARS-CoV-2; United Kingdom; Coronavirus (COVID-19) Infection Survey; evolution
The study analyzed the samples collected by the Office for National Statistics Coronavirus Infection Survey (ONS-CIS) to investigate the epidemiological and evolutionary dynamics of SARS-CoV-2. The findings showed that different lineages had distinct growth advantages during the study period, although there was a gradual decrease in average viral burdens. The study also observed increasing divergence and diversity within lineages, with step increases in divergence associated with major lineages.
The Office for National Statistics Coronavirus (COVID-19) Infection Survey (ONS-CIS) is the largest surveillance study of SARS-CoV-2 positivity in the community, and collected data on the United Kingdom (UK) epidemic from April 2020 until March 2023 before being paused. Here, we report on the epidemiological and evolutionary dynamics of SARS-CoV-2 determined by analysing the sequenced samples collected by the ONS-CIS during this period. We observed a series of sweeps or partial sweeps, with each sweeping lineage having a distinct growth advantage compared to their predecessors, although this was also accompanied by a gradual fall in average viral burdens from June 2021 to March 2023. The sweeps also generated an alternating pattern in which most samples had either S-gene target failure (SGTF) or non-SGTF over time. Evolution was characterized by steadily increasing divergence and diversity within lineages, but with step increases in divergence associated with each sweeping major lineage. This led to a faster overall rate of evolution when measured at the between-lineage level compared to within lineages, and fluctuating levels of diversity. These observations highlight the value of viral sequencing integrated into community surveillance studies to monitor the viral epidemiology and evolution of SARS-CoV-2, and potentially other pathogens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据