Nuclear compression regulates YAP spatiotemporal fluctuations in living cells

Yes- associated protein (YAP) is a key mechanotransduction protein in diverse physiologiof nucleoskeleton and cytoskeleton complex reduces nuclear compression for a given contractility and correspondingly decreases YAP localization. Conversely, decreasing nuclear stiffness via silencing of lamin A/C increases nuclear compression and YAP nuclear localization. Finally, using osmotic pressure, we demonstrated that nuclear compression even without active myosin or filamentous actin regulates YAP localization. The relationship between nuclear compression and YAP localization captures a universal mechanism for YAP regulation with broad implications in health and biology.

Automated summary

Changes in nuclear compression and nuclear stiffness regulate the localization of YAP, a key mechanotransduction protein. This discovery has broad implications in understanding health and biology.