期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2218830120
关键词
neurotransmitter corelease; cholinergic; claustrum; cell-type specificity
The cholinergic system in the basal forebrain has a crucial role in various behaviors such as attention and learning, by modifying the impact of noise in neural populations. The confounding release of acetylcholine (ACh) and GABA by cholinergic inputs to the claustrum, a structure involved in attention control, has opposing effects on the electrical activity of claustrum neurons projecting to cortical and subcortical targets. This cholinergic switching between subcircuits offers a potential mechanism for neurotransmitter corelease in behaviorally relevant computations.
The cholinergic system of the basal forebrain plays an integral part in behaviors ranging from attention to learning, partly by altering the impact of noise in neural populations. The circuit computations underlying cholinergic actions are confounded by recent find-ings that forebrain cholinergic neurons corelease both acetylcholine (ACh) and GABA. We have identified that corelease of ACh and GABA by cholinergic inputs to the claustrum, a structure implicated in the control of attention, has opposing effects on the electrical activity of claustrum neurons that project to cortical vs. subcortical targets. These actions differentially alter neuronal gain and dynamic range in the two types of neurons. In model networks, the differential effects of ACh and GABA toggle network efficiency and the impact of noise on population dynamics between two different projection subcircuits. Such cholinergic switching between subcircuits provides a potential logic for neurotrans-mitter corelease in implementing behaviorally relevant computations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据