4.8 Article

Unveiling the catalytic mechanism of GTP hydrolysis in microtubules

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Summary: By studying GTP hydrolysis-deficient MTs, we found that their lattice structure is remarkably plastic, distinct from wild-type GDP-MTs. End-binding proteins of the EB family have the ability to affect the structure of mutant GTP lattices and promote the transition of the GTP cap. The seam plays an important role in MT stability.

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