期刊
MOLECULES
卷 21, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/molecules21070965
关键词
epithelial-mesenchymal transition; drug resistance; chemotherapy; cancer stem cells
资金
- Science and Technology Development Fund (FDCT) of Macau SAR [FDCT/119/2013/A3, FDCT/024/2015/A1]
- University of Macau [MYRG2015-00181-FHS]
Epithelial-mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT in cancer drug resistance has been increasingly recognized. Numerous EMT-related signaling pathways are involved in drug resistance in cancer cells. Cells undergoing EMT show a feature similar to cancer stem cells (CSCs), such as an increase in drug efflux pumps and anti-apoptotic effects. Therefore, targeting EMT has been considered a novel opportunity to overcome cancer drug resistance. This review describes the mechanism by which EMT contributes to drug resistance in cancer cells and summarizes new advances in research in EMT-associated drug resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据