期刊
MOLECULES
卷 21, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules21091128
关键词
microfluidic; in vitro 3D model; skeletal muscle; cardiac muscle; heart; organ-on-a-chip; electrical stimulation; mechanical stimulation
资金
- Italian Ministry of Health
- Office of the Assistant Secretary of Defense for Health Affairs through the Breast Cancer Research Program [W81XWH-15-1-0092]
In the last few years microfluidics and microfabrication technique principles have been extensively exploited for biomedical applications. In this framework, organs-on-a-chip represent promising tools to reproduce key features of functional tissue units within microscale culture chambers. These systems offer the possibility to investigate the effects of biochemical, mechanical, and electrical stimulations, which are usually applied to enhance the functionality of the engineered tissues. Since the functionality of muscle tissues relies on the 3D organization and on the perfect coupling between electrochemical stimulation and mechanical contraction, great efforts have been devoted to generate biomimetic skeletal and cardiac systems to allow high-throughput pathophysiological studies and drug screening. This review critically analyzes microfluidic platforms that were designed for skeletal and cardiac muscle tissue engineering. Our aim is to highlight which specific features of the engineered systems promoted a typical reorganization of the engineered construct and to discuss how promising design solutions exploited for skeletal muscle models could be applied to improve cardiac tissue models and vice versa.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据