相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery
Keith E. Arntson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction
Beow Keat Yap et al.
FEBS LETTERS (2016)
Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase
Jitendra R. Harjani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase
John B. Jordan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials
Bankala Krishnarjuna et al.
JOURNAL OF MOLECULAR RECOGNITION (2016)
Combined ligand-observe 19F and protein-observe 15N, 1H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase
Kirsty L. Richards et al.
SCIENTIFIC REPORTS (2016)
Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain through Protein-Observed F-19 NMR Spectroscopy
Clifford T. Gee et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Successful generation of structural information for fragment-based drug discovery
Linda Oster et al.
DRUG DISCOVERY TODAY (2015)
Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold
Shane M. Devine et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate
Rodrigo A. V. Morales et al.
SCIENTIFIC REPORTS (2015)
Structure and Dynamics of Apical Membrane Antigen 1 from Plasmodium falciparum FVO
San Sui Lim et al.
BIOCHEMISTRY (2014)
19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2
Eleanor W. W. Leung et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2014)
Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using 19F NMR
Xiaopeng Ge et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent
Beow Keat Yap et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide
Geqing Wang et al.
PLOS ONE (2014)
Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery
Disha Patel et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2014)
Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening
San Sui Lim et al.
AUSTRALIAN JOURNAL OF CHEMISTRY (2013)
Design and Evaluation of the Performance of an NMR Screening Fragment Library
Bradley C. Doak et al.
AUSTRALIAN JOURNAL OF CHEMISTRY (2013)
Development of Fragment-Based n-FABS NMR Screening Applied to the Membrane Enzyme FAAH
Chiara Lambruschini et al.
CHEMBIOCHEM (2013)
Fresh from the biotech pipeline-2012
Randy Osborne
NATURE BIOTECHNOLOGY (2013)
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J. Souers et al.
NATURE MEDICINE (2013)
Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion
Prakash Srinivasan et al.
NATURE COMMUNICATIONS (2013)
Simple and inexpensive incorporation of 19F-Tryptophan for protein NMR spectroscopy
Peter B. Crowley et al.
CHEMICAL COMMUNICATIONS (2012)
Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
Inge Van Molle et al.
CHEMISTRY & BIOLOGY (2012)
Screening Strategies to Identify New Antibiotics
Mark S. Butler et al.
CURRENT DRUG TARGETS (2012)
Fluorine local environment: from screening to drug design
Anna Vulpetti et al.
DRUG DISCOVERY TODAY (2012)
Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy
John B. Jordan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Vemurafenib: the first drug approved for BRAF-mutant cancer
Gideon Bollag et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Current applications of 19F NMR to studies of protein structure and dynamics
Julianne L. Kitevski-LeBlanc et al.
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2012)
Experiences in fragment-based drug discovery
Christopher W. Murray et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Structural and Functional Insights into the Malaria Parasite Moving Junction Complex
Brigitte Vulliez-Le Normand et al.
PLOS PATHOGENS (2012)
Peptide Inhibitors of the Malaria Surface Protein, Apical Membrane Antigen 1: Identification of Key Binding Residues
Erinna F. Lee et al.
BIOPOLYMERS (2011)
Apical Membrane Antigen 1 as an Anti-Malarial Drug Target
Christopher A. MacRaild et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction
Rowena S. Lewis et al.
JOURNAL OF IMMUNOLOGY (2011)
The influence of the 'organizational factor' on compound quality in drug discovery
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide
Michelle L. Tonkin et al.
SCIENCE (2011)
The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites
Mauld Lamarque et al.
PLOS PATHOGENS (2011)
Recombinant protein vaccines against the asexual blood stages of Plasmodium falciparum
Robin F. Anders et al.
HUMAN VACCINES (2010)
Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites
Dave Richard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation
Zhihe Kuang et al.
JOURNAL OF CELL BIOLOGY (2010)
Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4
Panagis Filippakopoulos et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
Anna Vulpetti et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
The rise of fragment-based drug discovery
Christopher W. Murray et al.
NATURE CHEMISTRY (2009)
An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery
Christine R. Collins et al.
PLOS PATHOGENS (2009)
Theoretical analysis of the competition ligand-based NMR experiments and selected applications to fragment screening and binding constant measurements
Claudio Dalvit
CONCEPTS IN MAGNETIC RESONANCE PART A (2008)
Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii
David L. Alexander et al.
EUKARYOTIC CELL (2006)
The most polymorphic residue on Plasmodium falciparum apical membrane antigen 1 determines binding of an invasion-inhibitory antibody
AM Coley et al.
INFECTION AND IMMUNITY (2006)
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis
AM Petros et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1
KS Harris et al.
INFECTION AND IMMUNITY (2005)
Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket
T Bai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes:: 19F NMR studies
G Anderluh et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Fragment-based lead discovery
DC Rees et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Fluorine-NMR experiments for high-throughput screening: Theoretical aspects, practical considerations, and range of applicability
C Dalvit et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)