期刊
POULTRY SCIENCE
卷 103, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.psj.2023.103175
关键词
chick; intestinal immunity; defensin
Poultry production is a crucial sector for human food and the health problems faced by chicks can lead to economic losses for breeders. This study suggests that Avian defensin 2 (AvBD2) could serve as a marker of innate immunity and robustness in poultry. The analysis of AvBD2 content in the cecum of fast-growing and slow-growing lines revealed individual variability and an inverse correlation with seric IgM levels in the fast-growing line.
Poultry production is an important agricultural sector for human food worldwide. Chicks after hatch often face health problems leading to eco-nomic losses that are deleterious for breeders. Avian defensin 2 (AvBD2) is a prominent host defense peptide of the intestinal mucosa of cecum and is involved in the resistance of poultry to bacterial pathogens. This pep-tide could thus represent an innate immunity marker of robustness of birds. To test this hypothesis by compar-ing fast-growing and slow-growing lines in different conditions of breeding, the chick's cecal AvBD2 con-tent was analyzed according to animal quality and immunity indicators. Chick's cecal tissue sections labeled by immunohistochemistry with newly developed specific antibodies revealed the localization of AvBD2 in the mucosa with high individual variability, without showing differences attributable to quality indicators, but interestingly showing inverse correla-tion with seric IgM levels in the fast-growing line. The availability of our anti-AvBD2 antibodies to the scien-tific community opens perspectives to identify the cellular sources of this defensin in the cecal mucosa and to investigate the organization and function of innate immune arsenal of birds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据