期刊
MOLECULES
卷 21, 期 9, 页码 -出版社
MDPI AG
DOI: 10.3390/molecules21091230
关键词
flavonoid; triazole; dimer; trimer; hybridization; structural diversity
资金
- Cambridge Commonwealth Trust
- European Research Council under the European Union [279337/DOS]
- AstraZeneca
- European Union (EU)
- Engineering and Physical Sciences Research Council (EPSRC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Medical Research Council (MRC)
- Wellcome Trust
- EPSRC [EP/J016012/1, EP/K039520/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1351980] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K039520/1, EP/J016012/1] Funding Source: researchfish
Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and development projects. Numerous flavonoid dimer systems, incorporating a range of monomers attached via different linkers, have been reported to exhibit interesting bioactivities. From a medicinal chemistry perspective, the 1,2,3-triazole ring system has been identified as a particularly attractive linker moiety in dimeric derivatives (owing to several favourable attributes including proven biological relevance and metabolic stability) and triazole-bridged flavonoid dimers possessing anticancer and antimalarial activities have recently been reported. However, there are relatively few examples of libraries of triazole-bridged flavonoid dimers and the diversity of flavonoid subunits present within these is typically limited. Thus, this compound type arguably remains underexplored within drug discovery. Herein, we report a modular strategy for the synthesis of novel and biologically interesting triazole-bridged flavonoid heterodimers and also very rare heterotrimers from readily available starting materials. Application of this strategy has enabled step-efficient and systematic access to a library of structurally diverse compounds of this sort, with a variety of monomer units belonging to six different structural subclasses of flavonoid successfully incorporated.
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