期刊
MOLECULES
卷 21, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules21040510
关键词
thymidine analogs; click chemistry; [Tc-99m(CO)(3)](+) core; tumor proliferation imaging; macrocyclic triamine
资金
- National Natural Science Foundation of China [21541001, 21171024]
- Foundation of Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education
Achieving a (99)mTc labeled thymidine radiotracer for single photon emission tomography (SPECT) is considered to be of interest. In this study, four novel thymidine analogs, 6a, 6b, 6c and 6d, were successfully synthesized via click reaction route and then radiolabeled using a [Tc-99m(CO)(3)](+) core to prepare the corresponding Tc-99m(CO)(3) complexes in high yields. These complexes were hydrophilic and had good in vitro stability. Biodistribution of these complexes in mice bearing S180 tumors showed that all of them exhibited accumulation in the tumors, suggesting that they would be potential tumor imaging agents.
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