期刊
POLISH JOURNAL OF VETERINARY SCIENCES
卷 22, 期 4, 页码 677-683出版社
POLSKA AKAD NAUK, POLISH ACAD SCIENCES, UNIV WARMIA & MAZURY OLSZTYN
DOI: 10.24425/pjvs.2019.129980
关键词
florfenicol; antibodies; bird; broilers; immunity; lymphocytes
资金
- Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences
- Wroclaw Centre of Biotechnology, programme the Leading National Research Centre (KNOW)
Florfenicol is a broad-spectrum bacteriostatic antibiotic commonly used for the treatment of systemic infections in farm animals. The aim of this study was to determine the effect of florfenicol on the percentage of T lymphocytes (CD3(+), CD4(+), CD8(+), TCR gamma delta(+) cells) and B lymphocytes (Bu-1(+) cells) and on total serum anti - sheep red blood cell (SRBC) haemagglutinin titer in the peripheral blood of SRBC-immunized broiler chickens. The study included three groups of broiler chickens differentiated by weight (0.5, 1.2, 2.4 kg). Florfenicol was administered orally at a dose of 30 mg/kg. The drug was administered eight times at 24 h intervals. The chickens were immunized with SRBC 24 h after administration of the third dose of florfenicol. Florfenicol increased the percentage of CD3+ blood lymphocytes with a corresponding decrease in the percentage of B lymphocytes in birds weighing 0.5 and 2.4 kg. Florfenicol reduced the production of total anti SRBC-haemagglutinins on day 5 after antigen injection in all three body weight groups of the broiler chickens. In conclusion, florfenicol exerted a modulating effect on the immune response of the birds and this should be taken into consideration when using this antibiotic for certain indications.
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